Tryptamino
Bluelight Crew
I have two questions regarding DRI's and DA's and their interactions. They're pretty big questions, and it's possible that they won't be able to be answered, and that's cool, but whatever you know, I wanna know.
1. I've heard several times that DRI's and DA's, when taken simultaneously, cancel out each other's effects, which makes perfect sense, and I have experienced this cancelation myself (snorting ritalin while on vyvanse, stopped the CNS stimulation immediately), but I've never seen a credible source stating that, yet I have seen medical documents saying that it's okay to prescribe methylphenidate/d-methylphenidate and amphetamine/d-amphetamine together (and I've known people who were prescribed these combos), which, if this cross-cancelation thing is true, would mean that medical doctors are actually prescribing medication that negates the effects of each other? This makes no sense to me, and I'm not convinced that the cross-cancelling effect that I experienced was anything more than placebo until I get some credible sources.
2. I've also heard that taking DRI's on the comedown of DA's potentiates the DRI significantly, which I personally will probably never try because the only DRI's available to me are either methylphenidate (which doesn't even get me high due to my stimulant tolerance, I only feel PNS stimulation regardless of dose) and coke that's probably around 30% pure at most. Anyway, if it's true that if taken in that order they cross-potentiate, let's say I take an dextroamphetamine IR orally. At around 4 hours later, if I took a dexmethylphenidate dose nasally; the dopamine that the d-amp had already released is now not reuptaking, therefore creating a surge of dopamine greater than both? Or does the potentiation occur by different interactions? Anyone who has experience with this combo please give me as much detail as to how you do this, and anyone who can find a credible source to confirm this theory, please do.
Also, if anyone has a source regarding general information on DA's and DRI's, their differences, unique properties, and interactions, please let me know.
This thread is for my educational use, too, because I had a discussion regarding this topic with my pharmacology professor (who I have known for a few years and is a drug addict and was a meth cook in the 90's) this morning after class, eventually leading to him deciding to assign a mini-symposium involving 10 selected students, each presenting a different topic regarding agonists, antagonists and reuptake inhibitors. Obviously this is my topic, and my interest is absolutely not simply to get a grade, I've been wondering about these topics for a long time, having used and abused almost every DRI and DA under the sun, in fact the only stimulants that I know exist that I haven't tried are 4-MAR and 3C-P. Anyway, these were the topics that my professor and I were debating, and neither of us found a conclusive source, only wildly varying answers.
Anyway, since it is for school, I'd appreciate credible sources.
1. I've heard several times that DRI's and DA's, when taken simultaneously, cancel out each other's effects, which makes perfect sense, and I have experienced this cancelation myself (snorting ritalin while on vyvanse, stopped the CNS stimulation immediately), but I've never seen a credible source stating that, yet I have seen medical documents saying that it's okay to prescribe methylphenidate/d-methylphenidate and amphetamine/d-amphetamine together (and I've known people who were prescribed these combos), which, if this cross-cancelation thing is true, would mean that medical doctors are actually prescribing medication that negates the effects of each other? This makes no sense to me, and I'm not convinced that the cross-cancelling effect that I experienced was anything more than placebo until I get some credible sources.
2. I've also heard that taking DRI's on the comedown of DA's potentiates the DRI significantly, which I personally will probably never try because the only DRI's available to me are either methylphenidate (which doesn't even get me high due to my stimulant tolerance, I only feel PNS stimulation regardless of dose) and coke that's probably around 30% pure at most. Anyway, if it's true that if taken in that order they cross-potentiate, let's say I take an dextroamphetamine IR orally. At around 4 hours later, if I took a dexmethylphenidate dose nasally; the dopamine that the d-amp had already released is now not reuptaking, therefore creating a surge of dopamine greater than both? Or does the potentiation occur by different interactions? Anyone who has experience with this combo please give me as much detail as to how you do this, and anyone who can find a credible source to confirm this theory, please do.
Also, if anyone has a source regarding general information on DA's and DRI's, their differences, unique properties, and interactions, please let me know.
This thread is for my educational use, too, because I had a discussion regarding this topic with my pharmacology professor (who I have known for a few years and is a drug addict and was a meth cook in the 90's) this morning after class, eventually leading to him deciding to assign a mini-symposium involving 10 selected students, each presenting a different topic regarding agonists, antagonists and reuptake inhibitors. Obviously this is my topic, and my interest is absolutely not simply to get a grade, I've been wondering about these topics for a long time, having used and abused almost every DRI and DA under the sun, in fact the only stimulants that I know exist that I haven't tried are 4-MAR and 3C-P. Anyway, these were the topics that my professor and I were debating, and neither of us found a conclusive source, only wildly varying answers.
Anyway, since it is for school, I'd appreciate credible sources.
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