Limpet_Chicken
Bluelighter
Does the administration of a DARI prior to administration of an opioid (or the kicking in of a slower acting opioid, such as the prodrug codeine, or dihydrocodeine (in fact the opioid I am most curious about in this respect is dihydrocodeine, as I am prescribed this, but occasionally enjoy getting high instead of merely just using it for analgesia) directly block the euphorigenic action of the opioid?
I have twice had an experience with DHC that is quite atypical, a dose was taken on both occasions that would normally have me high as a kite, about
3/4th to half a gram of the tartrate salt, I am somewhat tolerant but not hugely so, my rx is for 30mg qds, sometimes I do use more, not enough to get high, but on occasion my knee pain is of sufficient severity to need it, but more often than not I use less, sometimes as little as 30mg/d average of 2x30mg/d, and of late I have been tapering down to lessen my tolerance, so this is NOT a tolerance issue, and the amount I took today, and the time previous this happened should most certainly have come on pretty strong.
Both times, desoxypipradrol was used, today at 2.5mg with an initial dose of
2mg plugged, and then a couple of hours later, a further 0.5mg was dosed orally (as a 1mg/ml solution in 40% EtOH) at the same time as the DHC was taken. Opioid was calming, did, and is providing analgesia although not as much so in the latter case as per usual at the recreational dose range used, and certainly prevented any autie-related sensory irritation, BUT, bugger all to very little euphoria that I can attribute to the DHC.
I'm guessing blockade at DAT is inhibiting DA release by the opioid?
You ADD guys agree with that theory?
Other question: if I were to take the same dose of DHC, or thereabouts, I.E enough to properly get off on it, and THEN take the desoxy after the opiate feels as though it has kicked in as strongly as it is going to, is it likely that it would cut short the high by shutting off further, ongoing DA release, OR, is it more likely that once the desoxy started acting, that it would enhance the euphorigenic properties of the DHC due to inhibiting reuptake of the released DA? or is a mixture of both effects more likely? inhibiting further release, but prolonging the high?
And if the latter of the three, which is likely to predominate, and is it more likely that the total euphoria/enhancement of cognitive processing and attention span would be greater than that of solely the opiate, or less?
Note: I do not find desoxypipradrol to be euphoric much, very, very little in fact, although I choose to use it at a dose no higher than 2-3.5mg or so, I did once try it at 5mg, but I found that rather too much for me, not overstimulating, the stuff is nearly imperceptible to me as far as peripheral stimulation goes, just the way I like stimulants (normally I HATE stimulants, but my cognitive, executive function, and attention focussing ability now are utter shit so finally I chose to resort to a stimulant). I'm not seeking recreational effects from the desoxy, but I don't want it interfering with any recreational use of opioids.
I have twice had an experience with DHC that is quite atypical, a dose was taken on both occasions that would normally have me high as a kite, about
3/4th to half a gram of the tartrate salt, I am somewhat tolerant but not hugely so, my rx is for 30mg qds, sometimes I do use more, not enough to get high, but on occasion my knee pain is of sufficient severity to need it, but more often than not I use less, sometimes as little as 30mg/d average of 2x30mg/d, and of late I have been tapering down to lessen my tolerance, so this is NOT a tolerance issue, and the amount I took today, and the time previous this happened should most certainly have come on pretty strong.
Both times, desoxypipradrol was used, today at 2.5mg with an initial dose of
2mg plugged, and then a couple of hours later, a further 0.5mg was dosed orally (as a 1mg/ml solution in 40% EtOH) at the same time as the DHC was taken. Opioid was calming, did, and is providing analgesia although not as much so in the latter case as per usual at the recreational dose range used, and certainly prevented any autie-related sensory irritation, BUT, bugger all to very little euphoria that I can attribute to the DHC.
I'm guessing blockade at DAT is inhibiting DA release by the opioid?
You ADD guys agree with that theory?
Other question: if I were to take the same dose of DHC, or thereabouts, I.E enough to properly get off on it, and THEN take the desoxy after the opiate feels as though it has kicked in as strongly as it is going to, is it likely that it would cut short the high by shutting off further, ongoing DA release, OR, is it more likely that once the desoxy started acting, that it would enhance the euphorigenic properties of the DHC due to inhibiting reuptake of the released DA? or is a mixture of both effects more likely? inhibiting further release, but prolonging the high?
And if the latter of the three, which is likely to predominate, and is it more likely that the total euphoria/enhancement of cognitive processing and attention span would be greater than that of solely the opiate, or less?
Note: I do not find desoxypipradrol to be euphoric much, very, very little in fact, although I choose to use it at a dose no higher than 2-3.5mg or so, I did once try it at 5mg, but I found that rather too much for me, not overstimulating, the stuff is nearly imperceptible to me as far as peripheral stimulation goes, just the way I like stimulants (normally I HATE stimulants, but my cognitive, executive function, and attention focussing ability now are utter shit so finally I chose to resort to a stimulant). I'm not seeking recreational effects from the desoxy, but I don't want it interfering with any recreational use of opioids.
