Harm Reduction dangers of iv methylphenidate vs other drugs

[GABAking]

i know IVing is bad. period. no debate.

but from what i've gathered, it seems there's a lot more horror stories when a person IVs ritalin vs. other pharms, whether stims or opioids

am i misinformed or is this the truth? if it's true, could someone please offer me the reason why?


thanks everyone.

 

[Tony Williams]

I've IV'edm Ritlain alot back in the day I had Pakistan generics that were 250mg in weight but only had 10mg Rit. Think Novas are 120ng(10mg irt) so it's alot crap. At first yeah I got+loved the rush, I kicked IV stims. Another SIMILER drug is called Ethylphenadate the IV rush aint as clean stimmy but more owww yeah seronticy. but with ETH you can't pish it too far as sideeffects hit but on the plus side its pure so you're taking in just 20mg-30mg however it IS quite corrosive, Read below.

Stay safe brah

 

[Tony Williams]

Dug some shenz out for you from another board.

Ritalin: Consequences of Abuse in a
Clinical Population

Abstract
This study examined the use of methylphenidate (Ritalin) among
clients of drug abuse treatment programs. A review of the literature
suggested that serious complications are to be expected from frequent
abuse of Ritalin, particularly if administered i.v. Treatment personnel
have also suggested complicating factors surrounding the abuse of
Ritalin during outpatient treatment for opiate dependency. A consecu-
tive series of admissions (N = 192) was examined for their use of
Ritalin, with special attention given to history of use, means of supply,
and adverse consequences associated with the abuse of this substance.

http://www.scribd.com/doc/90889177/10826088209071018rit

An Outline of Hazardous Side of Ritalin (Methylphenidate)

Ritalin (methylphenidate) has been used with much success in attention deficit
disorders of children. It has also been shown to be effective in narcolepsy, which
is a sleep attack disorder. The literature also reveals a very limited possible ef-
fectiveness for Ritalin in very mild depression, senile withdrawn behavior, and
apathy. Even though t h ~ s clinician feels that Ritalin is effective in attention deficit
disorders of children, he has extreme reservations about the use of t h s stimu-
lant in any other conditions. The Physicians'Desk Reference does not list all of
the specific side effects of t h s medication, especially those that have been seen
in psychatric patients. Because Ritalin is a DEA Schedule I1 Drug with high
abuse potential, it may have great legal implications for physicians who prescribe
Ritalin in a casual fashion.


http://www.scribd.com/doc/90899700/1082608860902hazrit

This is a Swiss study (and more recent too):

Severe toxicity due to injected but not oral or nasal abuse of methylphenidate tablets

Summary

BACKGROUND: Non-medical use of methylphenidate is increasing. Little is known about potential acute medical complications associated with recreational use of methylphenidate.
STUDY AIM: To identify medical problems associated with methylphenidate abuse.
METHODS: Retrospective case series of methylphenidate abuse cases presenting to an inner city emergency department.
RESULTS: We identified 14 cases of methylphenidate abuse between 2003 and 2010. Ten of these patients abused methylphenidate alone while four co-ingested other drugs, mainly alcohol. The route of ingestion was oral in nine patients, nasal in one and intravascular in four. Severe toxicity was exclusively observed in users who injected the drug. Two cases involved accidental intra-arterial injection and resulted in tissue necrosis leading to the amputation of a forearm and of fingertips, respectively. Clinical findings in the non-serious cases included mild to moderate symptoms and signs of sympathetic nervous stimulation such as agitation, tachycardia, hypertension, anxiety, hallucination, headache, tremor and dizziness. Nine of the fourteen patients were taking methylphenidate as a prescribed drug. Eight patients were former or current multiple substance abusers.
CONCLUSION: Methylphenidate misuse is not a significant burden for emergency departments in Switzerland. Oral and nasal administration of methylphenidate did not result in severe toxicity. However, injection of crushed methylphenidate pills lead to serious local toxicity. Most patients with methylphenidate abuse had a prescription for the drug indicating deviation from medical use. A history of multiple substance use may be a risk factor for non-medical use of methylphenidate.

http://www.smw.ch/content/smw-2011-13267/

There are loads of studies regarding MPH abuse, I was interested in EPH and hoping some of these papers would give some insight into EPH

 

[moor12]

Findings: PA and lateral chest radiographs show large lung volume with basilar predominant emphysema... The expiratory image shows marked air-trapping in the lung bases.
Diagnosis: Ritalin lung disease
Discussion: Intravenous injection of methylphenidate hydrochloride (Ritalin) can lead to a basilar predominant panlobular emphysema, identical to that seen in alpha-1-antitrypsin deficiency. It is believed that the non-soluble particulate filter (often talc) becomes trapped within the pulmonary arterioles and capillaries when the drugs are crushed and injected. The particles then migrate through the vessel wall into the interstial tissue and lead to aggregations of multinucleated giant cells. The pathophysiology of the basilar predominant emphysema is unkown.

References:
1. Stern EJ, Frank MS, Schmutz JF, Glenny RW, Schmidt RA, Godwin JD.
Panlobular pulmonary emphysema caused by i.v. injection of methylphenidate (Ritalin): findings on chest radiographs and CT scans. AJR. 1994 Mar;162(3):555-60.

I've found this information. I think this is the main danger of injecting crushed Ritalin tablets. There were many cases of people developing this disease after long term abuse.

 

[GABAking]

damn. thanks for the info. im in medical school and have learned/seen patients with alpha 1 antitrypsin deficiency. its a horrible disease. i'm not gonna ever iv these pills. thanks again for the knowledge