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Dangers of adderall?

whippa craka

whippa craka

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Jan 11, 2011
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I am aware of how stimulants are bad for your health in general, mostly because of malnutrition. But I have a few general questions. In my head I have always pictured adderall as being 'synthetic' methamphetamine the same way I picture oxycodone being 'synthetic' heroin. I was posting this in other drugs or basic drug discussion, but am deciding to post it in advanced drug dicussion because I am really interested in the long term effects like leading towards seratonin syndrome and other things of the such. I also love nicotine, caffiene (coffee), all that. I love the stimulant effect but I am worried about the dangers that the rush of dopamine/seratonin when first dosing on these things and the effects it has on you. My biggest concern would be that with adderall, as it is the most intense when comparing to your basic coffee or cigarette.

I usually take a 30mg XR and love the way it makes me feel, productivity goes through the roof and I feel like a completely fully functioning humand being for 10-12 hours. I am also much more caring, forgiving, open and down to earth with people. (I know because of the seratonin/dopamine rush) I usually dose every 3-4 days and then regularly go weeks at a time without taking any stims, I know when I take it and the XR is starting to kick in I can feel the rush of dopamine/seratonin... I do not chase this rush but I am wondering how much of a danger this is for me in regards to my positive outlook on life later down the road, the next day or even later that day I do feel a little more 'down', similar to a MDMA hangover but not as extreme. I feel like I can tell the difference between a stimulant comedown like coke and a hangover from such a dopamine/seratonin rush.

I am curious as to how serious of a risk it is with adderall. I know it can become a huge issue with Meth and you can end up 'burning out' your seratonin/dopamine receptors and feel down the rest of a majority of your life or many years... I am just trying to educate myself more. Comments are greatly appreciated and I am not asking a specific question but want to talk about this topic in general. Legggo :)

EDIT: I usually will drink some coffee and I used to pack lips while waiting for the adderall to come up because they all potentiate eachother VERY nicely... maybe a bad idea? I almost feel like I am rolling it is so enjoyable, but am very productive.
 
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Adderall is not "synthetic meth", nor is oxycontin "synthetic heroin". I recall an episode of some reality TV show called "Celebrity Rehab" (or something to that effect), in which that idiot "Dr. Drew" did not allow a patient to bring their Adderall prescription, likening it to "pharmaceutical methamphetamine". Point being; do not continue to propagate such myths.

As to your question, the answer is quite simple. Sporadic use of the dose mentioned should pose no measurable health risks (assuming you are an otherwise healthy adult). Aside from nicotine or caffeine, do not combine it with other drugs of abuse (namely other stimulant/psychedelics) or prescription meds (various anti-depressants, tramadol, DXM etc, etc).
 
I would like to understand further why they are myths. They are each in each others same class of drug and have a very similar molecular structure, also being much more potent with near duplicate effects
 
whippa craka said:
I would like to understand further why they are myths. They are each in each others same class of drug and have a very similar molecular structure, also being much more potent with near duplicate effects
Click to expand...

Different drugs with different effects and abusablility, please see my thread on amphetamine neurotoxicity for further information on adderall dangers. More or less above a certain point (lets say 10-25mg) the oxidative stress caused by amphetamine overwhelms your body's antioxidant defenses causing cell damage among other things.
 
However, they're not the same. A Porsche and a Ferarri may both be high-performance cars that go fast and they may even have the same shape and be painted the same color - but they are different things.

Though the drugs share similariries with their "illegal" friends, there are notable differences in duration and metabolism, and also availibility. For instance, methamphetamine lasts much longer than regular D-amphetamine, and is also a serotonin releaser. Oxycodone produces a qualitatively different experience from heroin, esp. regarding histamine release - and you can't really eat heroin and expect it to be effective, whereas oxycodone works well that way.
 
Your amphetamine frequency doesn't sound particularly risky and your doses are reasonable. Of course consuming lots of amphetamines, caffeine, and nicotine over a long period is going to put more of a strain on your body than if you were not consuming any of them. In the long-term smoking is probably what you should concern yourself with the most. Also, caffeine mixed with amphetamines can increase anxiety, although I do combine them pretty much daily. But if you feel fine the way you are using these then I don't see any immediate risk.

Also always good to pay attention to how you feel when you are not on amphetamines. If you notice that your days off are just spent waiting for the nextamphetamine day or burned out, then you'll be able to use that information to adjust your consumption.
 
Is this above comment about serotonin release true?

I thought the SERT receptors where inhibited in a similar manner that DAT was inhibited with d-amphetamine.

I am probably mixing up release and inhibition, I'm still trying to hammer in the pharmacology terminology so excuse my post. I am very interested in the pharmacology of amphetamines and I have been reading up a bunch on wikipedia but I understand it is not the best resource. I was wondering if anyone might be kind enough to point me in the right direction of more information about pharmacology and the pharmacology of amphetamines?

Thanks so Much

-baron
 
^ I think amphetamine does release serotonin... At least the wikipedia article about amphetamine says so.
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This effect is not physiologically relevant at dosages people would reasonably consume.

ebola
 
Ah so the amount of serotonin released is very small but with higher doses it will release more? What kind of doses do you think?

Also is it true that amphetamine inhibits the re-uptake of serotonin, but is this to a very large extent?

Sorry for all the questions
 
Amphetamine has no effect on serotonin release or reuptake at normal physiological levels, to the best of my knowledge. Methamphetamine, MDMA, and the ring-substituted amphetamines do, though.
 
Epsilon Alpha said:
Different drugs with different effects and abusablility, please see my thread on amphetamine neurotoxicity for further information on adderall dangers. More or less above a certain point (lets say 10-25mg) the oxidative stress caused by amphetamine overwhelms your body's antioxidant defenses causing cell damage among other things.
Click to expand...

Link to this thread?

=-=

As for monoamine transporters release, this article says otherwise:

http://www.bluelight.ru/vb/threads/...opharmacology-Text?postid=3473367#post3473367

the classical amphetamine action is to raise the extracellular concentration of monoamine neurotransmitters (dopamine, serotonin and noradrenaline).
Click to expand...
 
And one order of magnitude or so less than methamp's EC50 (meth can be a benchmark of the level where 5ht efflux, in comparison with other activities, becomes relevant for monoamine releasers).

ebola
 
even with hard drugs like meth, the propaganda has way overhyped the dangers. though meth is a very dangerous drug. but, many people experiment with drugs like
meth or crack several times (key word : experiment) and dont burn out their dopamine receptors forever. first of all, realize that adderall is like meth, but meth users
often take a lot of meth, that they essentially overdose; not overdose in the sense that they approach the LD50, but they overdose in the sense that they take so
much that they become psychotic and have very negative effects. dont get me wrong though: adderall is still a pretty dangerous drug. it is addictive, not in a physical sesense , but because you love how it increases productivity and also its euphoria. used occassionally: this is nothing to worry about.

ive taken adderall for over 6 years. my doc last year suddenly became super concerned about my weight and i said i cant take it in the summer or on weekends.
i was 17 at the time and my parents would enforce this.last summer, i felt really depressed, unmotivated, and had cravings for adderall that didnt begin to subside for 2 months. then they began to subside and i started to feel somewhat normal. then i went back on it when school started and it was really powerful again. suddenly going back on adderall 30 mg xr after not taking it for months..... ive never felt happier in my life. it only felt that good that one time though. meth has that
same property of not feeling as good as the first time, unless you abstain for a long time. but that is called tolerance. also, although i never tried meth, i doubt u
can become addicted to that the first time. i highly doubt that. first of all, its mainly psychologically addictive. and my addiction (if you can call it that, i crave adderall 24/7 when im off it, and when im on it i sit there worrying about if ill get taken off it ) to adderall, was based on both the good feeling and the memories of all the
times that ive been on it. the memories are what fuel many addictions ; from many substance addictions and when people obsess over their ex girlfriend or something).
of course , withdrawal also plays a huge role in addictions, but that develops over time and not one use. so the reason people seem to get addicted to things the first time is that it feels good the first time so they want to do it again, but they dont actually get truly addicted after they have done it quite a few times.


you wont get serotonin syndrome from adderall either.

its much healthier than meth though. think about it , people smoke grams of meth to get high. but , do you think they are smoking grams of pure methamphetamine?
absolutely not!grams of meth would kill someone and not be pleasant at all ; its probably like 100 mg of methamphetamine, so they are smoking 5 -10 percent
methamphetamine, and 90 -95 percent of potentially harmful impurities.

meth is more harmful than adderall mainly because of the differences in the reasons that people use meth vs. adderall. people use adderall to help them concentrate on a project or work (even if they buy off the street, they still see adderall as something to help them focus and not as a way to become euphoric). people use meth
for this reason, but it is used to enhance sex, help truckers stay up for days,, get high , etc. people see adderall as a study aid, so they use it more responsibly, and
since its in pill form , are more likely to stop at a low dose. but many people use meth to abuse it.
 
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