CYP1A2 and smoking

[Survival0200]

Hi! Does anyone have any idea on how much should you smoke, that it actually starts to induce the enzyme CYP1A2?

Is smoking a cigar every now and then going to have an effect on this enzyme?

I'm on a mediation which is a substrate of CYP1A2 - that's why I'm concerned.

Thanks!

(https://en.wikipedia.org/wiki/CYP1A2#Ligands)

 

[Kittycat5]

Which medicine? I imagine on cigar infrequently isnt a huge deal, but something like clozapine isnt something you really want to take chances with.

 

[Survival0200]

Yes, it's clozapine, but smoking actually decreases the effects of it, so it's not dangerous or anything.