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Stimulants Cyclazodone Megathread

deficiT said:
A vendor I know of is selling a 20mg/ml solution of N-Methyl-Cyclazodone. I'm thinking of picking some up to supplement my Vyvanse soon.
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Curious to know how that went. Cyclazodone (and probably NMC too--coming up on my first dose rn) are basically unsheduled equivalents to amphetamine. Have you tried out other ADHD meds besides Vyvanse? I'd imagine you might do better on a higher dosage or something with a bit of levo-amphetamine like Adderall or Adzenys.

I really liked Vyvanse because of how smooth the release mechanism was, but I would always reach for caffeine, modafinil, propylhexedrine, etc. simply because I was seeking something more noradrenergic and physically activating. I ended up getting the sharper headspace I was after, but the massive waves of anxiety and bone-crackling muscular tension brought on by my 'supplementation' would counteract a lot of the focus improvement I got from the Vyvanse.

Basically, stacking stimulant meds with powerful non-rx stims is a sign that you should either up your dosage or look into different compounds + formulations. But I'm not a doctor.
 
Miasma777 said:
Curious to know how that went. Cyclazodone (and probably NMC too--coming up on my first dose rn) are basically unsheduled equivalents to amphetamine. Have you tried out other ADHD meds besides Vyvanse? I'd imagine you might do better on a higher dosage or something with a bit of levo-amphetamine like Adderall or Adzenys.

I really liked Vyvanse because of how smooth the release mechanism was, but I would always reach for caffeine, modafinil, propylhexedrine, etc. simply because I was seeking something more noradrenergic and physically activating. I ended up getting the sharper headspace I was after, but the massive waves of anxiety and bone-crackling muscular tension brought on by my 'supplementation' would counteract a lot of the focus improvement I got from the Vyvanse.

Basically, stacking stimulant meds with powerful non-rx stims is a sign that you should either up your dosage or look into different compounds + formulations. But I'm not a doctor.
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Yeah, fair enough. Cyclazadone worked better for this purpose than NMC, as it's just smoother in general. I got to the point where I was taking it pretty regularly. It helped but got me too jittery and it eventually got tossed along with a bunch of my other drugs.

I take 60mg Vyvanse now, but have been on Dexedrine IR and Adderall IR 20mg daily before this. I definitely prefer the Vyvanse since it's just smoother and Iess jittery than straight Adderall. I still reach for energy drinks and stuff like that, but honestly I think I'm on the perfect dose for now. It could maybe be upped to 70mg and I might be happier. At the time I had the cyclazadone I believe I was only on like 40-50mg Vyvanse, so the increase definitely helped.
 
I have seen many anecdotal reports that NMC has the potential to be more euphoric than Cyclazodone. I found the opposite to be true. NMC is much more functional and makes me emotionally flat (I suppose this is what others refer to as 'robotic'). Cyclazodone is much more euphoric.* YMMV as with most things.

I much prefer both NMC/C over Adderall. Cleaner and smoother onset and drop off. As others have said, NMC has a very long duration.

Plus, at least with NMC, no noticeable tolerance build up. I haven't really tried Cyclazodone daily to see if there is tolerance.

* NMC @ 20mg vs C @ 15mg
 
Has anyone supplemented this with low dose (~200mg) Phenibut? I find that they are quite synergistic with each other.

(Note not F-Phenibut. Dosing with that is finicky. I prefer Phenibut FAA because it is slower and not as intense. Thus far managed to keep it under 700mg per day with weekends for breaks. No tolerance build up yet. )
 
TheSocialRecluse said:
Has anyone supplemented this with low dose (~200mg) Phenibut? I find that they are quite synergistic with each other.

(Note not F-Phenibut. Dosing with that is finicky. I prefer Phenibut FAA because it is slower and not as intense. Thus far managed to keep it under 700mg per day with weekends for breaks. No tolerance build up yet. )
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I have before, and yes they do work well together.
 
Anyone have any info on the solubility of Cyclazodone? I know it's not really water soluble, but I would hope that it would dissolve alright in some propylene glycol. My plan is not to make something I can vape, but just to have something easier to dose and measure, like liquid volumetric dosing.
 
deficiT said:
Anyone have any info on the solubility of Cyclazodone? I know it's not really water soluble, but I would hope that it would dissolve alright in some propylene glycol. My plan is not to make something I can vape, but just to have something easier to dose and measure, like liquid volumetric dosing.
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The formulations I have seen out there typically have Cyclazodone in a solution of propylene glycol. Check out ** NO SOURCING** (thought apparently they are now closing.)
 
Last edited by a moderator:
TheSocialRecluse said:
The formulations I have seen out there typically have Cyclazodone in a solution of propylene glycol. Check out ** NO SOURCING** (thought apparently they are now closing.)
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Thank you for the information, but don't forget we don't allow sourcing on this forum so please don't post vendor information.
 
My lab rat tried 10mg of this, from a bottle I had purchased last year. And wow. His symptoms of severe sleep apnea and ADHD were lifted just as effectively as with amphetamines (if not more)!

Is this even used anymore or has the FDA stifled science for good with this research chemical?
 
Somebody I know has been diagnosed with the initial phase of pulmonary hypertension after using Cyclazodone at 10-15mg daily for about a year. While this could be due to hereditary factors, we should not discount that Cyclazodone is chemically related to 4-Methylaminorex which is known for this side effect.
 
Pastel said:
Somebody I know has been diagnosed with the initial phase of pulmonary hypertension after using Cyclazodone at 10-15mg daily for about a year. While this could be due to hereditary factors, we should not discount that Cyclazodone is chemically related to 4-Methylaminorex which is known for this side effect.
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Damn.

Cycle your RC stims, bros
 
So there is a new variant of cyclazodoone out there: 2-Chlorocyclazodone. Has anyone researched this? I even asked the maker as to the reasoning but received no response.
 
Miasma777 said:
Curious to know how that went. Cyclazodone (and probably NMC too--coming up on my first dose rn) are basically unsheduled equivalents to amphetamine. Have you tried out other ADHD meds besides Vyvanse? I'd imagine you might do better on a higher dosage or something with a bit of levo-amphetamine like Adderall or Adzenys.

I really liked Vyvanse because of how smooth the release mechanism was, but I would always reach for caffeine, modafinil, propylhexedrine, etc. simply because I was seeking something more noradrenergic and physically activating. I ended up getting the sharper headspace I was after, but the massive waves of anxiety and bone-crackling muscular tension brought on by my 'supplementation' would counteract a lot of the focus improvement I got from the Vyvanse.

Basically, stacking stimulant meds with powerful non-rx stims is a sign that you should either up your dosage or look into different compounds + formulations. But I'm not a doctor.
Click to expand...
Cyclazodone is not soluble in PG or VG, at least not to any degree that would make it a candidate for a vape solution. Tried a few basic things to get it there and wasn’t happening. The methylated version is however, and is quite effective that way. I’m about to try some experiments to see if different salts of cyclazodone may be more soluble as it is absolutely disgusting to vape and that was always the most effective and therapeutic ROA for me for NMC which I’m unable to obtain at the moment — vape juice in an electronic vape. If I was a badass I’d figure out how to methylate it myself but that’s way above my pay grade. The foil or oil burner route is inadvisable if you’re using it as a nootropic. If you’re using it recreationally I’d advise just go ahead and find a real recreational drug bc this one is not. Some opinions on forums may vary but if you’ve consumed a moderate to heavy amount of dopaminergic stimulants in the past, it ain’t gonna get you high.

EDIT: if people are finding cyclazodone in a PG solution, I’d suspect it has a bit of ethanol in it and that’s why it works. It’s fairly soluble in ethanol / methanol. Ethanol not something you wanna put in your vape juice tho
 
Xorkoth said:
Regular cyclazodone? I prefer the n-methyl-cyclazodone myself
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Have trialed 3 batches of NMC and 2 of regular and my assessment is the same. NMC was much much better for me, also much lower side effect profile and wider sweet spot with the dose. Also does not taste like toxic burning plastic kimchi when vaped. by the responses I’ve seen here and elsewhere it must be a biological thing because it’s pretty evenly spread.
 
purd said:
How bad is it to stack cyclazodone with PPAP? I tried it once and it made cyclazodone much more enjoyable.
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Not sure on that particular combo but having used a fair bit of PPAP I feel a responsibility to give a warning: if you are bipolar, PPAP will make you feel *fucking* amazing (when you feel amazing) and it will make you feel *fucking* depressed (when you feel depressed). The way it works to only boost dopamine that’s already out floating in the synapse (or whatever, I probably butchered that), well…. It does that for endogenous dopamine too; ya know, the stuff you produce yourself without taking powders and pills. From eating your wheaties and whatever that thing is they call “a balanced lifestyle” 🤷‍♂️ (no clue). What goes up really must come down with that stuff, I took it a lot with adderall and it surely boosted the adderall but made the crash equally worse too. there seem to be a few unicorns exempt to this law of physics and neuropsychopharmacology but they are indeed 🦄. Most of them seem to be running large tech companies or selling out arena tours amassing net worths with no less than 9 zeroes. I have established that I am surely not one of them. I’ve not seen this mentioned anywhere and I only figured it out once I stopped combining PPAP with other substances and when I was off my mood stabilizing meds. I bet they never trialed it on bipolar rats so it’s not in any of the data either. Makes sense though, antidepressants are contraindicated in bipolar and it was a derivative of selegiline as I recall. All that said, I’m a madman and will surely order again at some point, the stuff I get done in manic phase pays for the time I lose in depressed phase. And it’s not so low for me that it’s life threatening or anything. Seroquel makes life nice and serene and will surely be part of my “retirement stack” but is not conducive to being a high performer in a brutally competitive field. YMMV blah blah but for real, heed the warning re: bipolar. It will surely increase the effects of cyclazodone but cyclazodone is a racemic substance and who knows if those effects it increases will be pleasant or helpful, and how much worse any existing crash may become.
 
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