Since CNS stimulants seem to enhance the effect of an opioid, I'd go with yes. I could be wrong; but they do put caffeine in codeine tablets here in Canada. I asked my pharmacist the purpose and she said to increase the action of codeine.
The caffiene in codeine preperations is used for headache relief since it is a vasodilator. I think caffeine is a Cyp1a2 substrate an doesn't induce or inhibit the rest of the cyp system. They could potentially work well off of synergy but
unfortunately no first hand experience here. I think i might give it a go I like speedy opiate highs.