Cross tolerance between trazodone and mirtazapine?

[CrimpJiggler]

If you are physically dependent on trazodone, then switch over to mirtazapine, will you just end up being physically dependent on mirtazapine? Does anyone have experience with this?

 

[Flynnal]

I couldn't stop using mirtazapine...after a month of complete cessation...even titrating down slowly over 3 months...I had to go back on. I was on 90mg...now on 15mg

I just couldn't get to sleep without it. I found I could sleep with promethazine. Depression is a bitch, let me tell you.

 

[RodRamsey]

I'm currently withdrawing off suboxone and having trouble sleeping even with benzo/benydryl combo. Found a bunch of trazodone in my meds drawer, must be from an ex girl or something. Had no clue about it but now seeing its a hypnotic sedative like med for depression and knocks people out. Might try couple and see how it goes. How addictive are they? I only have limited supply 18-20 50mg tabs.

 

[bunge]

Trazodone isnt classed as an addictive drug as the sedation it causes, although potent, for most people is unpleasant.
Trazodone should be able to substitute for mirtazapine for sleep as they both work through the same method ie. H1 antagonism (antihistamine).
Personally, i prefer mirtazapine to trazodone as i think mirtazapine is alot more relaxing then trazodone and seems to work better with my anxiety.
50-100mg of trazodone should be enough to substitute for the mirtazapine, unless you have an insane antihistamine tolerance.
Others antihistamines are a viable alternative aswell (promethazine, diphenhydramine and hydroxyzine for example) and will likely have less side effects.

 

[RodRamsey]

Thats interesting, I might throw a couple in the mix to knock myself out until this heatwave over. The herbals I have are super sativa strong which I usually enjoy but rather have some couch lock indy action. That haze keeping me awake also, need some regs.