Couple questions about dxm, using it frequently

[Joewenston]

Well normally swim tries once a week, as it is what he heard was the reccomended use for it.
But swim only uses it with weed/ syntheticcannaboids, as he is a daily weed smoker it is very hard for him to keep the dxm usage to a week minimum, as he really enjoys the combo.
Basically its around 150 mg + weed.
Anyway he has been doing this and today will be his 3rd day straight doing it, whats the actual harm from "binging" on dxm, he has not been able to find much info with proof.

 

[Joewenston]

Oh also i get an extremely fast heart beat, one of my sober friends couldnt even count my pulse it was beating so fast, is this something to be worried about?
How can i actually tell when my heart is at the point of beating too fast?

 

[Repo]

I've been doing 150 to 250 with 2400mgs of neurontin everyday for about a month and I've noticed no adverse side effects as of yet. Aside from a little gastro distress. As far as the heart rate it is a possible side effect of dxm as well as some of the other ingerdients that can be found in the pills and syrups. From what I've learned thru reading an experience its a matter of keeping yourself calm, a lot of it has to do with anxiety. If it is at a concerning level and its a constant side effect for you I suggest you stop taking it.

 

[tBirdee]

Oh also i get an extremely fast heart beat, one of my sober friends couldnt even count my pulse it was beating so fast, is this something to be worried about?
How can i actually tell when my heart is at the point of beating too fast?

I THINK, that around ~160-170 bpm is gettin into the danger zone.

 

[Legerity]

If you are finding that your body does not handle DXM well, then it may be a good idea to reduce your usage.

Aside from physical side effects, it's important to have enough time that you are not in an altered state to be able to integrate these experiences with your ordinary level of consciousness. You are traveling down the rabbit hole and need time to come up and breathe for a bit. After an Ayahuasca ceremony they will recommend 3 days without touching any other substances or even having sex. Not for any moral reasons, just because removing distractions and using this time to turn inward will help you make the most of each experience.

 

[Joewenston]

Thanks for all the info and help so far guys, am i most likely gonna be okay considering ive done this combo countless times, ive also dosed 300 mg of dxm several times and 600mg of dxm once and im sure that was much harder on my heart.

 

[melange]

invest in a pulse watch

 

[psood0nym]

DXM is an SSRI. I've noticed symptoms of SSRI discontinuation syndrome after stopping use (this is pure powder). After discovering that combining it with ondansetron (a 5HT-3 antagonist) made for a very valuable high (only for me out of 3 others who tried it, unfortunately), I used it probably three or four times per week for many weeks in a row. I went for about two months like this before I stopped.

I noticed I would develop brain zaps about four days after the last dose. If I dosed DXM again, the zaps would stop while I was high and for a few days afterward. At first I thought the zaps were the result of using serotonin releasing drugs during this same period and that DXM stopped the zaps, but eventually I determined DXM was all that was needed to cause them in the first place. Taking just 30 mg twice a day was enough to stop them for about half a day without having to actually get high on DXM, and so I used that regimen to taper (just like people taper after quitting SSRI anti-depressants). The zaps go away after about four days if I don't take anything at all, but I've heard of people claiming they now suffer from PERMANENT brain zaps after stopping years of regular Cymbalta use (an SSRI anti-depressant). I've also read others report brain zaps after DXM cessation independently of using it in conjunction with ondansetron.

I wouldn't fuck around with taking DXM as often as every day for a month like Repo above, just like I would never take SSRIs everyday, even if they were prescribed for me. Permanent brain zaps would be a living nightmare, and it's possible DXM is even more prone to causing them than something like Cymbalta -- not to mention the other side effects people have reported after chronic DXM use.

 

[cosmic charlie]

After discovering that combining it with ondansetron (a 5HT-3 antagonist) made for a very valuable high

Were you using sublingual zofran, or the pills ?

What kind of dosage works best and how early should it be taken prior to the DXM ?

I'm very curious about this combination, and any answers would be much appreciated.

 

[Kamuix]

DXM is an SSRI. I've noticed symptoms of SSRI discontinuation syndrome after stopping use (this is pure powder).

Ahh yes so I'm not alone there, I just posted something about this here: http://www.bluelight.ru/vb/showthread.php?t=548025

And strangely enough I just started using powder not long ago too and I've been doing dxm for 2 years and never had the good old zapping sensations until now. Although I recently did too much dxm but I can't help but think if the pure powder isn't mixed properly the right things it sometimes results in more a serotonin high? Actually when I first used the powder and didn't mix it properly, dxm felt more like MDMA for a bit then it ever had before, can you relate? Now only 5 days sober the zapping sensations and a mild around the eye headache and some other mild symptoms of low serotonin and yea can't wait for them to ease off.

But back to topic, 150 milligrams is a pretty low dose anyways and doses like that used 3 times a week or so will probably not be an issue, I'd just.. not do it for overly long. If anything you may notice changed with your memory.. or not.

 

[psood0nym]

Were you using sublingual zofran, or the pills ?

What kind of dosage works best and how early should it be taken prior to the DXM ?

I'm very curious about this combination, and any answers would be much appreciated.

I use 16 mg orally (two tablets) at the same time I use the DXM (pure powder in a capsule). I started out using just 4 mg and noticed every time I used DXM with it was like the the best of my DXM trips in the past without it, so I tried a higher dose of ondansetron.

For me, the difference is pretty radical. The trip is far more lucid, euphoric, and down right manic. Combing it with LSD may have been the best experience of my life.

For two of the three others who have tried it the trip was substantially more lucid than DXM alone, but not substantially more euphoric or manic as it is for me. The last of the others who tried it reported no noticeable differences between it and a normal DXM dose. Like DXM by itself, the combo seems pretty finicky between people.

Ondansetron is broken down by the same enzyme that breaks down DXM to DXO, so the ratio of the two may be changed using high dose ondansetron (though according to Wikipedia it has little effect on other drugs broken down by the cytochrome P450 system, so maybe not -- then again 16 mg is a much higher dose than is normally prescribed). Additionally, the excess serotonin in the synapse as a result of DXM's reuptake inhibition is of course prevented from binding to 5HT-3 receptors, which are associated with anxiety reactions and nausea. Perhaps some of the dysphoric effects of DXM are mediated by serotonin binding to 5HT-3 receptors, and when this action is blocked in certain lucky individuals DXM becomes a much better drug. Those are the two known mechanisms I can think of to somewhat explain the presence of an interaction.

If you try it using ondansetron from India break the tablets before swallowing. The one time I didn't break them I got nauseated and had a "normal" DXM trip. I assume the tablets were manufactured hard to survive shipping and don't dissolve properly when swallowed whole (as I've read about some other Indian meds). Good luck. Let me know if it works for you.

Kamuix: I definitely relate to the serotonin high when using the combo of DXM and ondansetron (my vision gets really swimmy and of course there's a strong euphoria), but not from using the pure powder alone. I've only ever used pure powder so I can't comment on differences between it and syrup. What do you mean about the powder not being "mixed properly"? I don't mix it with anything.

 

[psood0nym]

Ahh yes so I'm not alone there, I just posted something about this here: http://www.bluelight.ru/vb/showthread.php?t=548025

And strangely enough I just started using powder not long ago too and I've been doing dxm for 2 years and never had the good old zapping sensations until now. Although I recently did too much dxm but I can't help but think if the pure powder isn't mixed properly the right things it sometimes results in more a serotonin high? Actually when I first used the powder and didn't mix it properly, dxm felt more like MDMA for a bit then it ever had before, can you relate? Now only 5 days sober the zapping sensations and a mild around the eye headache and some other mild symptoms of low serotonin and yea can't wait for them to ease off.

I made a short response to you in my last post, but I'm making a new post to remind you that DXM can be used to stop the zaps. In the future if you absolutely need them to stop, I'd try 50 mg, wait about three hours, and see if they stop. Since you've gone five days already without using DXM it's probably best if you just continue. They will most likely stop soon. It's possible that if you take any DXM at all that you could "reset" the cycle of zaps, though I will say when I tapered using 30 mg twice a day I only experienced zaps for two days after quitting entirely (when I usually would have had four days of zaps without the taper). I have to imagine the zaps were more likely caused by increased frequency of dosing after you got the pure powder than by the powder itself. Even if you've been using DXM for two years have you been using the doses you've been using with this frequency? The more you use the more serotonin gets trapped outside your neurons and gets broken down without being replenished in time.

 

[cosmic charlie]

Thanks for all the excellent info psood0nym.

I had no idea that it could make the trip more euphoric and lucid, i was just hoping for it to help with the nausea while I go for some higher doses. This sounds like it's going to be even better than I previously imagined. I'm so excited, this is going to be my next experiment for sure. Probably gonna dive in this weekend when I have a clear schedule, I'll let you know how it goes. I'll be using 16mgs of zofran and 700mgs of DXM.

 

[psood0nym]

Don't get your hopes too high! Remember, though some effect was observed in three out of four people who've tried it, only I experienced the "full" effects. I hope it does work for you, though. I'll be interested to hear, whatever the case.

 

[Kamuix]

I made a short response to you in my last post, but I'm making a new post to remind you that DXM can be used to stop the zaps. In the future if you absolutely need them to stop, I'd try 50 mg, wait about three hours, and see if they stop. Since you've gone five days already without using DXM it's probably best if you just continue. They will most likely stop soon. It's possible that if you take any DXM at all that you could "reset" the cycle of zaps, though I will say when I tapered using 30 mg twice a day I only experienced zaps for two days after quitting entirely (when I usually would have had four days of zaps without the taper). I have to imagine the zaps were more likely caused by increased frequency of dosing after you got the pure powder than by the powder itself. Even if you've been using DXM for two years have you been using the doses you've been using with this frequency? The more you use the more serotonin gets trapped outside your neurons and gets broken down without being replenished in time.

About the frequency thing you're right about that because first of all I don't have a good sensitive scale to measure in milligrams but no honestly I began using dxm at around the same frequency for a bit.. but then my old friend came to visit and I semi binged and had been gotten high 4 - 5 times a week(for 2 weeks). So way too much obviously but not only that there was a few times where i took about 200mgs before going to bed because I gave me a uniq pleasant sleep and when I would wake up in the morning 8 hours later I felt so happy and the morning felt so positive, for a few minutes anyway it's not like I was still high but for some reason waking up felt like the brightest happiest morning to wake up to, then I was normal.. strange. But yea.. too much DXM.

I tried to reply to your question you asked about the mixing through PM but i'm not aloud to PM yet and I didn't want to create a long off topic post that may irritate the OP.

Oh.. I posted about it here:http://www.bluelight.ru/vb/showthread.php?t=544265

It lead to me researching 'DXM and PEG' and finding this:http://www.dextroverse.org/Archives/absorb.txt

Which kind of explained what my problem may have been and although I haven't tried mixing the pure dxm powder with juice or anything else I actually was in a hurry and just mixed the DXM powder in with abit of DXM cough syrup... so there's probably better solutions to that bad tasting not so good solution. But because I was kind of doing dxm half in half with syrup and powder I'm still not 100% sure if I solved the problem but the effects seemed back to normal.

Note: my powder is not a hydrobromide salt either but I don't think that effects absorption or does it?

EDIT: I have KANNA but was affriad to use it in fear of prolonging it. I also have 5-htp which i don't know if that would help the situation or not.