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Kratom Could rosuvastatin be interfering with Kratom?

M

Mycophile

Bluelighter
Joined
Mar 3, 2014
Messages
4,582
So I recently started taking a Rosuvastatin for cholesterol, and I'm pretty sure that I did manage to get high a few times from Kratom and OPMS extracts since taking it, but for the most part I haven't been getting good effects from Kratom lately. However, I THINK this is probably more cause I was just using too many extracts so it's raised my tolerance. However, on reddit there's this person who is claiming that Rosuvastatin competes for the same liver enzyme as Kratom and that it is interfering. I'm REALLY hope this person is wrong cause I need to take this statin so there's nothing I can do and I LOVE Kratom. I guess I could skip the statin certain days but I don't know how long it stays in your system.

PLEASE someone confirm for me that it's my tolerance and NOT the statin making it harder to get those good feelings from Kratom...
 
Based on the AI overview, Kratom and Rosuvastatin seem to work on different liver enzymes: "The primary kratom alkaloid, mitragynine, inhibits the cytochrome P450 (CYP) enzymes in the liver, particularly CYP3A4." "Rosuvastatin is minimally metabolized by the liver, with the primary enzyme involved being CYP2C9. "

I really hope this means that my statin isn't affecting my reaction to Kratom.
 
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