I'm actually 30%Native American and I have 'troubles' with alcohol like how I can't drink without downing hard shit or shit that's mixed up and many of those mixed drinks to feel anything/if anything at all. Now you are correct that genetics have a HUGE role in how kratom exfects the people of their native lands of Asia, etc... It's seems in one book I read about how kratom was a big substitute for opium back when they made it illegal and started blowing poppy fields to shite. Supposedly kratom has become a norm in South Asia, to South East Asia; so to make it less likely for people to use it they become to hate the herb of the grand kratom tree, & again blowing/cutting down hectors of kratom trees in all country's around Asia in general. Now I just went on a benzo rant lol my bad but, yes, you're right that since the people used this herb for sooo long their off spring had major problems like addiction to WD that's like opium WD due to genetics sadly. The people tend to get really fucked up off of kratom and seem to cause trouble sometimes or are elders who use it for pain management but those elders/people have to take MASSIVE doses up to 58 grams every twice a day and the WD is sooo much worse than it would be for me or you. Hints why it's illegal in Asia now.