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  • BDD Moderators: Keif’ Richards

Benzos could i IV klonopin?

nylyak76

nylyak76

Greenlighter
Joined
Jul 3, 2014
Messages
11
Ok, I’m sure this is a stupid question but I thought I’d ask anyway. I was wondering if I could get it to dissolve with some citric acid or something like that.
 
COULD you, well yeah, you can IV anything you can put into a syringe in theory. SHOULD you, absolutely fucking not, for the love of god please don't.

Since you said "klonopin" and not "clonazepam" and mentioned specifically trying to dissolve it in citric acid for some reason we're obviously not talking about pharmaceutically pure clonazepam here but your intent is to dissolve some pills and inject them. You should never ever ever do this, this is how people lose limbs. The equipment that you have is not sufficient to remove all the other nasty stuff making up the inactive binders in pills that will clog small blood vessels pretty much permanently until you've done it enough times that you lose an arm - this is obvious just by the fact that you're even asking this question.

There's also very little point, clonazepam if I'm not mistaken is almost 100% orally bioavailable. Someone has surely done it, regardless, but there is zero chance that whatever the difference in speed of onset feels like compared to just taking them orally outweighs the enormous, enormous risks.

I know this thread is a few weeks old but since no-one's replied yet, hopefully you didn't try, if you did try, please don't do it again.
 
Ive had IV valium and IV ativan from hospital vials. Only difference was it kicked in quicker. Didnt hit stronger at all. Imo not worth it
 
iv benzodiazepines do not effect the dopamine reward pathway so they don’t cause a rush.. the bioavailability of oral benzodiazepines is commonly really strong.

So injecting them won’t benefit over oral roa. it could have effect but this could be exacerbated due to roa, but likely it is psychosomatic.

oral and wait a few minutes and your in..
 
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Yeah.. sounds like a terrible idea. Most benzos are so poorly soluble in water, I'd be worried even if you could get it into a citric acid solution, that it would drop out in the bloodstream and potentially cause heart attack/stroke/tissue damage etc.

Thank God I don't use benzos anymore.
 
Don't
You only can inject pharma products meant to be injected, ampoules are the obvious example.
IVing pills is a very bad idea. You are far better taking it orally. Also, many benzos are very poorly soluble in water, don't know specifically about clonazepam's solubility, tho. But I'd be surprised if you could disolve the thing in water.
Injected benzos' effects aren't too different than eaten, they only hit sooner. I have been Injected diazepam in ER and it felt like orally administration, it acts faster and that's it.
There are other meds, like hidromorphone where IV route is far superior than oral. But not clonazepam.
 
neversickanymore said:
iv benzodiazepines do not effect the dopamine reward pathway so they don’t cause a rush.. the bioavailability of oral benzodiazepines is commonly really strong.

So injecting them won’t benefit over oral roa. it could have effect but this could be exacerbated due to roa, but likely it is psychosomatic.

oral and wait a few minutes and your in..
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I IV'd etizolam in vodka and blacked out. Stupid but it did provide a rush. That only happened once, led to me smoking (best way to take it, always has a rush and enough to fit on the tip of a cigarette is easily manageable) and orally taking 250mgs in a day or two, equal to 125mgs of alprazolam. Broke my parents dishes, locked myself out if the house and knocked on the door to get in right away. Then went to get a haircut and the woman sternly asked "Why would you come here like this?!" I had a very uneven hair cut.

After this and my smoked phenezapam week long blackout I stopped abusing benzos.
 
^ nope i fully disagree. @BorbOrB The highest bioavailability is oral and last time i checked there was only one published paper that hypothesized a reward pathway link to benzodiazepines.

People experience roa rushes.. Some people have posted about shooting water when they are out of substance.

What are you considering a rush? rapid onset isn’t a rush.
 
neversickanymore said:
^ nope i fully disagree. @BorbOrB The highest bioavailability is oral and last time i checked there was only one published paper that hypothesized a reward pathway link to benzodiazepines.

People experience roa rushes.. Some people have posted about shooting water when they are out of substance.

What are you considering a rush? rapid onset isn’t a rush.
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Exactly what "rush" could mean given any experience with said rush. GABAergics provide rushes if they take effect quickly enough. Nitromethaqualone provides a MASSIVE rush and parkinsonian symptoms although I dont believe its dopaminergic either but correct me if im wrong. Smoking or IVing etizolam does provide a very pleasurable rush and sedation. Sometimes pharmacological data doesn't allow you to know everything and hypothesize wrong based on no lived experience. Same problem applies to doctors and psychiatrists who have never and will never do the drugs they are prescribing.
 
neversickanymore said:
^ nope i fully disagree. @BorbOrB The highest bioavailability is oral and last time i checked there was only one published paper that hypothesized a reward pathway link to benzodiazepines.

People experience roa rushes.. Some people have posted about shooting water when they are out of substance.

What are you considering a rush? rapid onset isn’t a rush.
Click to expand...
What is a "rush" if not overwhelming rapid onset that pleasurable? Its different neurotransmitters but a rush just the same as IV meth just qualitatively different.

And comparing it to shooting water is disingenuous to what happens.
 
neversickanymore said:
well i guess we have to define a rush

what’s your definition?
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A massive influx of pleasurable or even non pleasurable neurotransmitters that provide a rushing sensation, overwhelming almost pleasure that comes on fast enough to be described as a "rush". If you experience a dooaminergic rush, you have rhe experience to tell if another drug is providing a rush. I promise you if you smoke Nitromethaqualone, it'll be an almost scary rush. Etizolam isn't as intense but it comes on fast enough to provide a "rush" sensation. MDPV doesn't cross the BBB as fast as cocaine and doesn't provide much of a rush but still extreme euphoria.

I think if it crosses the BBB fast enough, there are multiple drugs that arent dopaminergic that can provide a rush.
 
neversickanymore said:
What drugs provide a rush that are not reward pathway drugs?

Do you feel non reward pathway drugs are addicting?
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I haven't tried but I can assume norepinephrine provides a rush. I'll have to ask someone who's used an epi pen though. NE likely has a lot to do with IV cocaine and meth rushes and isn't specifically euphoric from what I know.

No, I dont think non reward pathway drugs are addicting but someone can become addicted to drugs that arent exactly pleasurable and even stimuli that isn't exactly pleasurable perse but there is probably some secondary reward pathway action as in self mutilation.
 
BorbOrB said:
I haven't tried but I can assume norepinephrine provides a rush. I'll have to ask someone who's used an epi pen though. NE likely has a lot to do with IV cocaine and meth rushes and isn't specifically euphoric from what I know.

No, I dont think non reward pathway drugs are addicting but someone can become addicted to drugs that arent exactly pleasurable and even stimuli that isn't exactly pleasurable perse but there is probably some secondary reward pathway action as in self mutilation.
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it’s a common misconception that dopamine is pleasurable.. dopamine has little to do with pleasure. can you think of a substance that causes a norepinephrine spike wo a dopamine spike?
 
neversickanymore said:
it’s a common misconception that dopamine is pleasurable.. dopamine has little to do with pleasure. can you think of a substance that causes a norepinephrine spike wo a dopamine spike?
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Ive tried more noradrenergic drugs and they arent as pleasurable as drugs with higher dopamine output. D2 and D3 agonists and partial agonists cause impulse control problems and changes in sexuality and are pleasurable, things like abilify arent pleasurable but cause the same impulse control problems, indicating that dopamine is pleasurable in at least some sense, regardless of what agonist action is being had at those receptors. Impulse control problems indicate that dopamine is rewarding and pleasurable and cause people to seek out external dopamine increases such as gambling, sex, eating, shopping addiction behaviors. I would say, yes dopamine is conclusively pleasurable.
 
Jesus Christ man. Drink something carbonated, down the Kpin (with one airport bottle shot if you're that hard up) and inject some saline or something if you have to. Do not get into the habit of injecting nasty stuff. Not only is trying to rail it a bad idea, clonazepam is 100% bioavailable orally and you're not beating that.
 
neversickanymore said:
is it inherently or truly pleasurable though?

i’m not fkn with u. How does dopamine work?
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This is just kinda a philosophical question at best or a semantic quibble at worst, I think... And I'm not criticizing, it's kinda an interesting question in a vacuum.

You could say dopamine is not "inherently" pleasurable because, obviously, dopamine psychosis, the generally known fact that death from stimulant overdose is a bad way to go, subjectively, the fact that dopamine is moreso a reward anticipation facilitator than it is an "inherently pleasurable" neurotransmitter, ie, dopamine is typically a motivator to action which depletes rapidly when the goal is achieved. So it's not inherently pleasurable, sure, you could even say that it induces a somewhat false pleasure in that it takes a very short time for homeostatic neuroadaptations to cripple the usefulness of the motivated feeling and kill the actual drive to action, and after that it can be a short road to breaking the reward association with the drive to activity, ergo, repetitive, paranoid, thoroughly unfun loops of activity without even the prospect of a reward.

I've skipped talking about receptor subtypes because I'd probably just garble the actual neuroscience but I think that this is a pretty accurate descriptor of the subjective phenomena that are bound to artificially elevated dopamine levels. Actually no, I'm gonna change my initial opinion about it being a semantic or philosophical quibble, I think that dopamine is not inherently or truly pleasurable, but the pleasure induced by dopamine agonism is a consequence of secondary effects induced by dopamine release, probably endogenous opioid release and/or some more complex stuff - and this is pretty quickly clamped down on by the brutality of our evolved tendency to maintain homeostasis in the brain at all costs even when it's actually a maladaptive adaptation in a world full of exogenous dopamine-inducers. I'm sure someone can fuck around with the definitions of pleasure and or what it even means for an endogenous neurotransmitter to be "inherently or truly pleasurable" and come to a different conclusion though.

I don't think this discussion is at all relevant to anything else in this thread, for the record, I just thought it was an interesting question in a vacuum.
 
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