sillypillyoclock
Greenlighter
- Joined
- Sep 9, 2023
- Messages
- 10
I’ve been prescribed the newly approved Auvelity, which is an extended release tablet of 45mg of dextromethorphan HBr and 105mg of bupropion HCl. I’m on my seventh day, and have a bit of an unusual reaction to it, it gets me quite high (vast majority of people do not get any recreational value out of this). That’s not really what this post is about, though (I asked that question in another place).
I’ve heard reports of people who take Auvelity suddenly have it stop working. Someone described it as a “Flowers for Algernon” type situation. Could this be because of DXM’s notorious tolerance building issue? Could this be avoided by altering the dosing schedule (i.e, 2 weeks on, 2 weeks off)?
Or am I doomed to slowly lose DXM’s magic, and its magical antidepressant qualities, and develop an irreversible tolerance? I should also mention I am a poor metabolizer of CYP2d6.
I’m honestly really worried about this. This medicine is really helping my depression so far, and I don’t want to ruin that. Even this measly XR 45mg feels a bit like low dose ketamine for me.
Of course, I wouldn’t change anything about my medications without consulting my provider.
I’ve heard reports of people who take Auvelity suddenly have it stop working. Someone described it as a “Flowers for Algernon” type situation. Could this be because of DXM’s notorious tolerance building issue? Could this be avoided by altering the dosing schedule (i.e, 2 weeks on, 2 weeks off)?
Or am I doomed to slowly lose DXM’s magic, and its magical antidepressant qualities, and develop an irreversible tolerance? I should also mention I am a poor metabolizer of CYP2d6.
I’m honestly really worried about this. This medicine is really helping my depression so far, and I don’t want to ruin that. Even this measly XR 45mg feels a bit like low dose ketamine for me.
Of course, I wouldn’t change anything about my medications without consulting my provider.