Coryphantha calipensis

[nuke]

This odd looking cactus, which appears somewhat like a snowcapped mountain, contains an interesting and very possibly psychoactive chemical called calipamine, or 3,4,beta-trimethoxy-n-methyl-phenethylamine. We know that the beta-methoxy configuration of several compounds can yield very potent serotonergic results (albeit questionably toxic). From BOH in PiHKAL, the beta-methoxy group also seems to keep a compound that would otherwise be inactive (MDPEA) in the body about as long as alpha-methylation would, with a similar potency.

Several Coryphantha species have been found to contain psychoactive alkaloids, notably hordenine, calipamine, and macromerine (Schultes et al 1998)

http://www.thewildclassroom.com/biodiversity/floweringplants/extras/cactaceae hallucinogenics.htm

 

[LuxEtVeritas]

i would expect an effect related to mescaline perhaps and maybe minor hints of MDMA as well -- a hybridized effect, LOL?
actually likely very similar to BOH itself as well as 3,4-DMA which is noted at high doses to be mescaline-like

 

[Xorkoth]

I would love to hear anything about this, particularly bioassays.

 

[Ham-milton]

Has anyone assayed macromerine?

Wikipedia says it's " psychedelic, hallucinogenic and entheogenic of the phenethylamine family" but it doesn't look like something that's going to be very active. I'd imagine a fairly high dose would be needed, correct?

I wonder about a lot of the PEAs Shulgin wrote off as inactive without going very high in doses. I mean, I've had 100mg of mescaline before and didn't feel anything noticable, but at 350mg's I had the best psychedelic time ever.

How can you try 100mg of something and say, "oh well, it's inactive" when one of the most beautiful psychedelics in nature doesn't really manifest until 2.5 times that dose?

 

[mad_scientist]

Yeah I've thought the same thing myself, Shulgin says in one of his books that a compound has been "given the kiss of death by being inactive at 50mg"

Now obviously I can understand toxicity concerns etc, but 50mg is not that high a dose...if you tried 50mg of mescaline you could certainly dismiss it as inactive, same with ibogaine. Makes me wonder if several of the ones he dismissed as being inactive might be valuable compounds at higher dosages.

I seem to remember reading a bioassay of macromerine where they reckoned it was weakly active at doses of 500-1000mg, but I don't think it was anything very special even at that dose. Now if something isn't decently active at 1000mg then I think its much more reasonable to dismiss it as inactive - although I guess if you tested sodium GHB at 100, 500 and 1000mg you might well say, "well it was starting to show some sedative effects at 1000mg, but I didn't want to go any higher, this compound is obviously inactive"...

 

[hugo24]

Macromerine,hmm,what were this (newly discovered) cactus compounds(mixture?) Sasha mentioned in Basel as being "psychedelic,and immensly so!" ?

 

[Morninggloryseed]

You saying Shulgin confirmed the psychoactivity of macromerine?

 

[hugo24]

No.Unfortunately I don't remember all the specific compounds he mentioned (a methylated Mescaline could have been one),but I think he didn't know either what caused the strong experience.He though suspected it must have been a combination of two part. compounds.Can anyone help me out to fill the hole in that story?