Correlation between blood plasma and intake of caffeine

[shishigami]

So I was doing some research for a paper for gym and found http://www.theannals.com/cgi/content/abstract/22/12/953 which is exactly what I want but not the full article. I was wondering if anyone has an idea of what this equation might be, or another article I can look at that would help in determining the plasma concentration of caffeine based on caffeine intake.

Thanks.

 

[amapola]

Hi shishigami.

A great tool for finding information like this is google scholar. It's a google search engine that focuses on academic studies, patents and articles.
http://scholar.google.com

If you search it for caffeine plasma levels I'm sure you'll find what you need. Furthermore if you want to find the concentration of caffeine as a function of time, you'll be looking for something called the 'half-life' which is how long it takes for half the caffeine to be metabolized by the body. Usually some sort of logarithmic function.

Good luck and if you need any help just ask.

 

[23536]

you don't really need pubmed or google scholar, just a physiology primer or the equivalent

University of Nottingham tutorial

wiki article on same

 

[shishigami]

Thanks for the ideas, I had just been searching google before which didn't lead to much.

I'm basically trying to figure out how much caffeine one would need to drink to fail a competitive sport drug test with a threshold of 15 ug/L. I know that I can just look that number up, but that's not satisfying and I would like to get an idea of what percentage is in the blood and what percentage is in the urine. Unfortunately all the papers that could help are not free (or cheap for that matter, $34 per paper...).

 

[sekio]

Head to your local university library and see if you can look some of those papers up then A lot of libraries will allow the general public to go peruse the stacks in exchange for a modest copying fee.

Is the 15 ug/L a blood test, urine test, or some other figure?

 

[shishigami]

I misread one of the sources, since they switch between ug/mL and mg/L. The test cutoff is 15 mg/L in urine for the NCAA and 12 mg/L in urine for the olympics.

I found what I needed which basically said for people workign out the urine concentration is ~= to the dose in mg/kg they took. Which means you need to ingest a large amount of caffeine to fail the test and at that amount you would probably be ill.

 

[...]

I misread one of the sources, since they switch between ug/mL and mg/L.

They're the same thing.

Oh, I see your point.