converting animal to human doses

[Doctor Abalaba]

I have some unanswered questions from the other thread on this.
I have a formula buried in my files to roughly convert human to animal dose (actually to a range of doses via varying the exponent).
Anyway, I want either that formula, or a rat/mouse dose for this stuff.
Also, anything by way of behavioral effects?

 

[vortex30]

Wait...What drug? I'm sure it depends from drug to drug, and as far as animal dose goes, all you will be seeing is LD50s? All I know is I've seen mice take 100 or 200x more per weight than monkeys, and then you assume monkeys will be similar to humans.

So...Explain what you are wanting to do more...I'm sure we can help find you a proper human dose, unless this is some weird, not-ketamine thing you've taken from the vet and wanna do weird experiments on yourself with! :D

 

[vecktor]

see the FDA guidance notes on initial human trials which has the surface area approximation/ coorection between species for setting inital trial doses

if you want to ask specifically about tcb-2 you already have a thread about it, post it there.

 

[LuxEtVeritas]

how do people now know this?!

rats divide by 6, mice by 12 as a general rule to get human dose

ie. 180mgkg mouse = 90mg/kg rat = 15mg/kg human

obviously most studies are rats and mice and hence not to know this is to be ignorant of the correlative dose relationships

note sometimes they use huge doses for specific effects and it is not really correlative to anything therapeutic as relates to humans

i like when they use an active well known standard like DZP so than i know if they are using 1.2-2.4mg/kg in a mouse it is 0.1-0.2mg/kg equivalent humans as a ration which is ~7-15mg human dose shows that the dose is in range of therapeutic indices and whatever they are comparing it to would have a correlation to that

 

[youarewhatyouis]

wait a second, are you trying to get your dog high?

 

[Doctor Abalaba]

Watch what you say, PETA might coming knocking down my door.

Sorry for bothering but I thought its was a standard formula, so thought one of you guys may know it off hand.. [I lost some binders]

No, actually, has nothing to do with tcb-2. Im trying to confirm a dose recommended by a colleague for a pilot this summer. DiPT ... but only have an estimation. If nobody has nothing new to add about tcb-2, then trash it. I just don't trust that formula to generate new doses; I use it as confirmation (like a less reliable second opinion).

I played around with the formula and if you vary that exponent, as well as calculate a range of weights; the dose-range was very close to what I looked up (Amph, Modafinil, DPT, and now DiPT).




BTW-
Neuropsychopharmacology (2007) 32, 1404–1420.

Alterations in Body Temperature, Corticosterone, and Behavior Following the Administration of 5-Methoxy-Diisopropyltryptamine ('Foxy') to Adult Rats: a New Drug of Abuse

Michael T Williams, Nicole R Herring Tori L Schaefer Matthew R Skelton, Nicholas G Campbell Jack W Lipton Anne E McCrea and Charles V Vorhees