Continuing thread comparing efficacy between benzodiazepines: temazepam & alprazolam

[AlphaOdure]

Continuing thread comparing efficacy between benzodiazepines

my experience & background:

I take 1000mg-1750mg (max) of butalbital daily to control seizures (its a barbiturate), 2400mg to 3600mg of gabapentin; and 4mg of buprenorphine (subutex formula)

With that said; only some benzodiazepines seem to work; don't know if there is a CYP hepatic interaction there or what?

BUT: i have an Rx to temazepam, & for me at least? 30mg through 90mg works best; but mostly as a hypnotic.

alprazolam (name brand "xanax"), is actually a triazolobenzodiazepine (i.e., just a benzodiazepine molecular skeleton WITH an added triazole ring attached to it). However, i feel next to nothing aside from increased barbiturate effects; even above 4mg of alprazolam! its probably my least favorite benzodiazepine

• etizolam is hands down the best for anxiolysis;
• temazepam (sleep)
• clonazepam for anxiolysis/sedation/sleep... just all around.
• diazepam anxiolysis (a traditional 1,4-benzodiazepine)
• Others? like lorazepam & alprazolam really do jack shit. 3000mg of gabapentin works better for me, actually.

But! that's just me!

Any comments? As i'm continuing an older thread here that had been closed

 

[AlphaOdure]

take that back... I took 2mg of alprazolam (xanax) last night & was knocked out cold.

This could be b/c i did a detox down to roughly 1/2-2/3 my typical butalbital/barbiturate use.. so perhaps the butalbital does have some interaction w/ triazolobenzodiazepines.. err, benzodiazepines w/ a triazole ring attached to it?

 

[bunge]

I would say its a liver enzyme problem. Benzodiazepines (triazolos or otherwise) should increase the effects of barbiturates as they dont bind to the same subreceptor, so there shouldnt be any competition.