Thanks for the response! I do not administer ketamine therapy and have never worked in any places that offer it. The vast majority of folks I work for are on public assistance for insurance, either as public welfare benefit or due to disability. Ketamine, generally speaking, too much of an out of pocket cost for most of my folks to even consider, so I understand how your own limits on access are likely pretty frustrating.
I will say that there is benefit in knowing that you *can* feel better. Even if the tool is not something you can access as often as you'd like, it will remind your soul that you don't always have to feel the way that you do. Perhaps being able to experience that degree of an uplift can create positive momentum. I'm a big believer in the notion that our suffering can be very strongly associated with feeling stuck or inertia. When we feel trapped by depression, for example, the amount of energy required to fix all of the things that occupy our mind, reminding us of why we feel badly, is immense. Even trying to sort out and start working on aspects of our lives can feel like a task onto itself. I'm not sure how depression manifests for you, but I imagine there is some ways in which feeling stuck or held motionless and unable to muster the volition to move forward can be quite difficult.
Ketamine's properties are such that a rapid increase in associative learning in its aftermath is often noted, as well as a temporary increase in willpower as well as impulsivity. Impulsivity can be helpful if used to begin engaging in helpful things that you would normally avoid out of fear or routine. It can be bad if it leads you into unhealthy activities, so something to be mindful about. Generally speaking, having someone talking with you about some of this stuff will be helpful in offering personal guidance as to how to use it. I would just try to have some ideas of how you want to use the days and weeks following your session to begin some growth focused activities. Get some momentum going in a positive direction that matters, perhaps something basic like physical fitness. It would be helpful to bring some of this stuff with you to talk with the clinician you are working with.
This was originally how we were going to use SSRIs but boy have the times changed in that regard.
30 years is a long time. Maybe it's a good thing that you're limited in how often you can access this treatment for at this time - I do think that it will give you a nudge in a unique and powerful way. I look forward to hearing about how your session goes.
Kratom is great for certain situations - I think of it as temporary boost to constitution or stamina. It's a little energizing, and can help me get through something frustrating/annoying and also pairs really well with exercise. The combination of endorphins and kratom is quite nice.
I too am curious about ULDN and have been looking at it off and on over many years since someone mentioned something about it on alt.drugs.hard or something back in the usenet days. It's always seemed to be just outside of anyone's experience to get any solid advice, though I do see it come up on reddit a fair amount. Is your regular naltrexone being used as part of "The Sinclair Method"? If so, I have a lot of respect for that approach and wish more people could see using naltrexone in a targeted rather than daily way is likely far superior in objective and subjective benefit.
It probably wouldn't be difficult to make a volumetric solution with 1 tablet (assuming they're 50mg) If so, you'd just dissolve one tablet in a 2 liter bottle of distilled water. You now have a solution of 50mg/2000ml which equals 25mg/1000ml, 2.5/100ml, .25/10ml, .025/ml, .0025/.1ml. As I understand it, there's a sweet spot for folks so you'd need to adjust based on how it works for you, but that's a dose within the therapeutic range that seems like a starting point. There are plenty of ways to find eyedroppers or syringes that will give you .1ml measuring accuracy.
I don't know anything off-hand, certainly strikes me as an interesting avenue for exploration. I will say that Ketamine and Kratom have a nice synergy. I would imagine that the prime benefit to ULDN and kratom would be the potentiation of effect and reduction in tolerance, assuming that kratom tolerance is modulated through similar mechanisms as morphine and other opioids. I know that it interacts with receptors in a different way than traditional opioids sometimes, but similarly in others. I don't know how ULDN and kratom would interact.\
Have you followed this thread on the site that discusses ULDN? I found it while responding to your comment.
Thanks for your questions and thoughts. I hope some of it helps.