Congenital defects in the opioid receptor system??

[Danny Al'thor]

Dose any one have any solid medical information on or if there is such a thing as a birthdefect in the opiate receptor system? As for I am a non-recreational user of legitimate opioids and can not get a straight anwser from my Drs. As to why I can take super human amounts of medication and still not gain relife or suffer side effects. Yet I still feel Withdrawls with out them? What is my problem? Are there options and real evidiance of said issue?
Thank you!

 

[sekio]

that's not a birth defect, you have simply accrued tolerance to the point where opioids do nothing positive for you any more

same deal as nicotine in cigarettes

 

[Danny Al'thor]

I should have mentioned that this has been a life long occurence.

 

[Mr.Scagnattie]

Some people just have a naturally higher tolerance to opiates. What's an example of a high dose of opiates given to you that didn't work as it should?

 

[Crashing]

We need more info. What medication and dosage did you start pain management on?

That'll tell a lot.

 

[Danny Al'thor]

As an adult i was in a car crash and broke my arm humerous?!? And was given 100 mg morphine in 4 shots in an hour and nothing happened. Then after 4 hrs of screaming pain i was given 20 mg hydromrphone in iv form not drip but again in 4 shots over an hour 5,5,5,5 then finally 25 mg of fentenaly now im pretty sure that that is a hefty dose for a non opiate tolerant person and i am pretty sure that the dosages are correct? So is that normal or not?
Thanks

 

[Crashing]

That's not normal by any means. You are immune to opiates, which i've never heard of.

That's actually absolutely insane as far as dosing a non tolerant individual.

 

[need-a-life]

It sure sounds like alot but having said that after working post op and a level 1 tauma ER I have seen people initially in extreme acute pain take loads of narcotics to control their pain. Plus changing the narcotic midcourse to another in hopes that that one will do the trick is very common.

Just out of surgery or new onset traumas can take a ton of narcotics to get over that hump then a more normal dosing can often take place depending on the injury. But who knows, everyone is different.