I know in the past they focused on changes in pre-synaptic D2 autoreceptors (I think) as the mechanism for tolerance and sensitization. It's been years since I was on adderall, and they've been tough years. I have a good opportunity and so have restarted Dexedrine to study this boring ass certification (tax law). If there was ever a more clear and present need for stimulants I would be surprised. After 3 days, my original dose lost effectiveness. Having rode this train before, I want to prevent or . . . impede this same development.
That being said, I hear NMDA blockade through a frontal loop leads to the sensitization. I did try namenda for a period of time long ago (10 years past), expecting it to reverse my tolerance, which it did not.
So, trying to figure this out now: Is there a connection between D2 up/down regulation and Glutamate or at least NMDA channels? I think I can get Memantine again my doctor is open-minded.
I'm hoping that, as I can see I'm outclassed even studying chemistry, someone may be able to give me literature on a connection between D2 dysregulation and NMDA channels? I've read, actually, of connections between D1 and NMDA. . . it's too much for me to digest and I'm seeing my pdoc wed. This could be the opportunity of a lifetime for me, hence all the pubmed searches and this question(s). Thank you. It is appreciated, PM me if you like. I have about 3/4 of a degree in biochem, decided to quit. If NMDA and D2/D1 are unrelated it seems like what's the point of the NMDA allosteric modulation? Does it still help? Well, thanks so much more than I can express in words for this community. If I didn't mention, I just bought the deslym tonight. Made me pretty sleepy for first dose. I just want to make it work say 4 or 5 days a week and not be an asshole to people when I'm recovering. I have Zn, and I'll get chelated Mg when I can as well. Again, thanks so much.
That being said, I hear NMDA blockade through a frontal loop leads to the sensitization. I did try namenda for a period of time long ago (10 years past), expecting it to reverse my tolerance, which it did not.
So, trying to figure this out now: Is there a connection between D2 up/down regulation and Glutamate or at least NMDA channels? I think I can get Memantine again my doctor is open-minded.
I'm hoping that, as I can see I'm outclassed even studying chemistry, someone may be able to give me literature on a connection between D2 dysregulation and NMDA channels? I've read, actually, of connections between D1 and NMDA. . . it's too much for me to digest and I'm seeing my pdoc wed. This could be the opportunity of a lifetime for me, hence all the pubmed searches and this question(s). Thank you. It is appreciated, PM me if you like. I have about 3/4 of a degree in biochem, decided to quit. If NMDA and D2/D1 are unrelated it seems like what's the point of the NMDA allosteric modulation? Does it still help? Well, thanks so much more than I can express in words for this community. If I didn't mention, I just bought the deslym tonight. Made me pretty sleepy for first dose. I just want to make it work say 4 or 5 days a week and not be an asshole to people when I'm recovering. I have Zn, and I'll get chelated Mg when I can as well. Again, thanks so much.
