• The Dark Side 💕 Welcome Guest 💕
    Posting Rules Bluelight Rules
    Notable Threads Urgent Hotlines
    Bereavement Mindfulness
    Suicide Support Anger Management
  • TDS Moderators: AlphaMethylPhenyl | paranoid android

Mental Health Coming off Invega/Xeplion (paliperidone) injections v. 9

Status
Not open for further replies.
www.verywellhealth.com

Dopamine: What It Does for You and Related Conditions

Dopamine is a brain chemical involved in motivation, pleasure, attention, movement, and more. High or low levels contribute to ADHD, Parkinson’s, and other conditions.
www.verywellhealth.com www.verywellhealth.com

this is good article for understanding what dopamine does.

Low Dopamine Symptoms​

Low dopamine activity can have different physical, cognitive (thinking), and emotional effects. The symptoms of the different conditions vary, depending on the region of the brain where dopamine activity is lacking.


Symptoms of inadequate dopamine activity include:


  • Rigid muscles that feel stiff and achy
  • Tremors9
  • Muscle cramps or spasms
  • Diminished balance and coordination10
  • A characteristic gait (walking pattern), often involving small, shuffling steps
  • Impairment of fine motor skills (like holding a pencil or threading a needle)
  • Constipation
  • Difficulty eating and swallowing
  • Cognitive impairment (“brain fog”)
  • Difficulties with focusing attention11
  • Fatigue
  • Lack of energy
  • Slow movement or speech
  • Mood swings
  • Low sex drive

What are the symptoms of dopamine deficiency?
  • You lack motivation, “the drive.”
  • You're tired.
  • You can't concentrate.
  • You're moody or anxious.
  • You don't feel pleasure from previously enjoyable experiences.
  • You're depressed; you feel hopeless.
  • You have a low sex drive.
  • You have trouble sleeping or have disturbed sleep.

What problems are associated with low serotonin levels?​

Low levels of serotonin may be associated with many health conditions including:


We just need time for our brain to get rid of all the dopamine and serotonin receptor blockade that's caused by invega.
we will be fine
 
Last edited:
InvegaAnon said:
Recovering after a year is a normal span of recovery. Some people recover in two and I've seen one person recover in three, all full recoveries. The only reason I haven't recovered is because I took Prozac but I don't have reason to believe this is permanent yet since I'm still improving.

Find yourself a therapist if you can, it helped me.
Click to expand...
How is a therapist going to help if I have been chemically lobotomized? Are they suppose to sing me a song or something? Are they going to say some magical words that are going to heal me? No. There is nothing a therapist can do for me. I have been chemically lobotomized.
 
BelieveinGod123 said:
How is a therapist going to help if I have been chemically lobotomized? Are they suppose to sing me a song or something? Are they going to say some magical words that are going to heal me? No. There is nothing a therapist can do for me. I have been chemically lobotomized.
Click to expand...
They can keep you alive and stuff.

It's not permanent. There's people who have recovered completely. If you actually believed people you would chill the fuck out.
 
InvegaAnon said:
They can keep you alive and stuff.

It's not permanent. There's people who have recovered completely. If you actually believed people you would chill the fuck out.
Click to expand...
Risperidone (Risperdal)
Invega Sustenna (Paliperidone Palmitate)

Both are irreversible antagonists.
 
BelieveinGod123 said:
Risperidone (Risperdal)
Invega Sustenna (Paliperidone Palmitate)

Both are irreversible antagonists.
Click to expand...
It doesn't mean it won't ever leave your brain. Irreversible antagonists eventually get removed from the brain because receptors are temporary structures, they are proteins on the surface of a cell. It goes away when the receptor proteins are recycled. Receptors are very dynamic, they have to be.

I have no idea what is happening to people who struggle with this permanently, but it's not because invega is still in their brains. I'm not denying there can be a permanent effect, but it's not because palipedrone is an irreversible antagonist on some receptors. I think some peoples' hormones don't return to normal or there is new dysfunction in the production of neurotransmitters. This drug was designed to force the brain to make less dopamine and serotonin over time, along with some other neurotransmitters like histamine, which is great if you have severe schizophrenia, but it's very bad for you if you don't.
 
Last edited:
BelieveinGod123 said:
Risperidone (Risperdal)
Invega Sustenna (Paliperidone Palmitate)

Both are irreversible antagonists.
Click to expand...
Who said it is irreversible? Could you provide information sources? I can’t find any sources that says it is irreversible.

Receptors are already temporary structure that regenerate within few days.

When I vega is out of system, there is no effect in our brain.
 
It's pretty easy. All you have to search on Google is "Risperidone irreversible antagonist" you will find more then plenty of information.

Risperidone and Invega are the same drug.
 
i’ve been experiencing taking more time to sleep than i normally would like i would lie there thinking and i thought i was sleeping until something happens. anyways do we still experience rem sleep? i do have dreams. i heard untreated rem sleep could kill a person… i hate the doctors
 
iraistired said:
i’ve been experiencing taking more time to sleep than i normally would like i would lie there thinking and i thought i was sleeping until something happens. anyways do we still experience rem sleep? i do have dreams. i heard untreated rem sleep could kill a person… i hate the doctors
Click to expand...
Mine got better after a few months. I was using a low dose of Mirtanzapine to help sleep, but I'm off it now and sleep has returned
 
BelieveinGod123 said:
It's pretty easy. All you have to search on Google is "Risperidone irreversible antagonist" you will find more then plenty of information.

Risperidone and Invega are the same drug.
Click to expand...
Yeah I read about that too and it only served to scare me. I remind myself that people have healed and recovered 100%, so that idea clearly isn't affecting them
 
BelieveinGod123 said:
It's pretty easy. All you have to search on Google is "Risperidone irreversible antagonist" you will find more then plenty of information.

Risperidone and Invega are the same drug.
Click to expand...
The irreversibility isn't as big of a deal as it sounds. I was really scared when I found that out too. Now I don't worry that it's still with me. I worry about a neurotransmitter deficiency and changes to my neurological structure.
 
No, Haldol (haloperidol), Xeplion (paliperidone palmitate) and Risperdal (risperidone) are not irreversible antagonists. They are antipsychotics that act primarily as dopamine D2 and serotonin 5-HT2A receptor antagonists, but reversibly. This means they bind to the receptors to prevent dopamine (or serotonin) from acting, but their binding can be detached, allowing the receptor to return to normal function after the drug is eliminated from the body.

An irreversible antagonist, on the other hand, binds permanently to the receptors, altering their function until they are replaced or degraded, which is not the case with these antipsychot
 
iraistired said:
like u were bad bcuz of the drug then got better then got bad then got better? cuz i was getting better with sleep then that happened ..
Click to expand...
Ah no I mean I was really struggling with sleep, and used Mirtanzapine to help. Then I quit it and turns out I can sleep okay again. But I make sure to do some exercise during the day to tire myself out and try not to smoke cigs before bed, general good sleep hygiene.
 
stolensoul said:
Ah no I mean I was really struggling with sleep, and used Mirtanzapine to help. Then I quit it and turns out I can sleep okay again. But I make sure to do some exercise during the day to tire myself out and try not to smoke cigs before bed, general good sleep hygiene.
Click to expand...
But yeah I was having terrible insomnia the first 3 months since getting off the injection. It felt like I would just teleport to being awake again.

I also have a tinnitus which makes sleeping rough. Really shit combination with coming off invega
 
There needs to be a recovery FAQ, facts about invega, and recovery story collection on the first page.

Proposal for FAQ answers and facts:

We need the estimated time of elimination but in total days and not the half-life equation bullshit, because some people aren't great at math or their mathematical abilities are impaired by the shots. And for every version of the medication; sustenna, trinza and hafyera.

It needs to be stated it is normal to take 1-2 years to recover and recovery can continue even after that, but that is more rare and people should expect to recover in a year.

It is a fact the "irreversible antagonist" detail isn't a big deal.

People are more often than not still fertile after the medication leaves their system, but the risk for infertility increases with the length you have been on it.

Tremors and parkinsonism are likely to resolve but some people will have permanent tardive dyskinesia.

Sexuality often fully recovers.

It is not safe to take an SSRI after you had invega sustenna because it can give you PSSD with severe depersonalization/derealization and full anhedonia if you didn't have anhedonia from invega.

It can take two years for hormone levels to return to normal.

Added later: St. John's Wort helps metabolize invega faster. There could be a risk of making the self-tapering feature of the injections go too fast, so be careful and be aware of what your brain is doing so you don't get rebound psychosis. Don't take it if you have an autoimmune disease.
 
Last edited:
Status
Not open for further replies.
Top