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Mental Health Coming off Invega/Xeplion (paliperidone) injections v. 10

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Trueart2 said:
It’s possible it has to be, at the very least it’s been reported things go back to normal; especially for people who only had 1-2 injections. I doubt it’d be legal to utilize if generally we didn’t go back to normal
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I mentioned those two cus both only got one shot. @brokenself got one shot and hasn’t been the same it’s been over a year
 
I used to wake up at 5:30 every day before I got these injections. Now I just sleep as much as I can. I woke up at 7 today and then slept again at 10. Woke up close to 2pm…. That’s my life now.
 
The excessive sleep from invega went away at 13 or 14 months off. Legit over the span of a week I was sleeping from 13 hours a day to now a consistent 7-8 nothing more nothing less
 
rawbanana said:
I mentioned those two cus both only got one shot. @brokenself got one shot and hasn’t been the same it’s been over a year
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Yeah I’m not sure what it is, according to the Invega documentary we have a 77-80~ chance of recovery regardless of circumstance. I’m not sure what it is, but nobody who took supplements in their recovery I’ve seen not recover yet. Same thing with people who can get high after smoking marijuana they all recover.
 
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Abilify2mg said:
The excessive sleep from invega went away at 13 or 14 months off. Legit over the span of a week I was sleeping from 13 hours a day to now a consistent 7-8 nothing more nothing less
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Your body was still recovering and changing from the shots at that point
 
I am feeling minor improvements so I’m trying to remain hopeful that recovery is possible. It’s all I can do.
 
rawbanana said:
I haven’t heard that
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It’s in my signature, I wouldn’t be able to pull the Link to the study up immediately, but it’s tattered through the old Invega forums. I’m not exactly on this but it produces the P-GP protein like @herbertadams was saying earlier. This protein pushes the invega out of your brain, and once again research based on bluelight testimony indicates being able to get high via smoking and recovery are correlated
 
I have no drive or motivation. Everyday I feel like doing nothing. There's nothing pushing me. My memories are blurry and I have no emotions.
 
herbertadams said:
As far as flushing your system from the injection CYPD26 and CYP3A4 might be responsible for metabolizing the drug you where injected with.

But as stated with a half-life of 19 days at 5 months in it's likely there is no more drug remaining in your system, unless you are unable to metabolize those enzymes/pathways properly.

That being said the doses of these injections often seem to be far outside of normal therepeautic range. One could deduce that the shrinks are loading patients up on as high of doses as they can possibly get away with as a way to increase duration. Doubling dose effectively increases elimination by an extra half life at the cost of overdosing patient and causing more severe negative responses to treatment. For a drug with a 50 day half life this is pretty extreme.

If that's the case applicable inducers may help, probably worth getting blood checked to see if there's any drug remaining in your system before going to effort of trying to flush it out. Likely it's out of your system and inducers come with interactions and side effects.

There's something about reversible and irreversible antagonists too. Some antagonists such as paliperidone will irreversibly bond to the receptors. This however won't be as permanent as it sounds, after your system is clear receptors get recycled and new receptors can grow. Neuroplasticity agents may help hasten this process but it will happen by itself in hours, days and weeks after cessation. Again these come with extra interactions and side effects.

From what I have read it seems that after being on these drugs for long periods of time neurological changes occur, upregulation and down regulation of different receptors, neurons growing in new places, all sorts of nonsense. It goes a bit further than just flushing the offending drug from the system or reversing it's effect, as it's not just the effects of the drug but the neurological changes that these effects lead to that are of concern.

Scene set and setting are pretty important. Psychological changes might be more impactful on one's wellbeing than physical neurological changes. The psychological toll of being institutionalized and being placed on forced treatment may have more of a negative impact on the patient than the neurological changes from the drug.

What are your current symptoms?

I'm not an expert mate, none of this should be taken as fact, just trying to understand it.
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These are my symptoms. It severely reduced my joy,motivation,happiness and severely restricted my emotions, I feel emotionless. Thinking is hard and dull and I constantly forget things when I'm currently thinking about them. It's hard to feel good from good memories. How do I upregulate my dopamine receptors? What drugs should I use?
 
herbertadams said:
Can you post the study or a source for that?
From a quick google "cannabis is not a p-pg inducer and in fact, prolonged exposure to cannabinoids like THC and CBD generally leads to a decrease in P-gp expression and/or a weak inhibition of its function."
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I got you in the morning, I’d have to dig through all the messages to find it
 
pubmed.ncbi.nlm.nih.gov

Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana - PubMed

The ATP-dependent drug efflux transporter P-glycoprotein (P-gp) plays a significant role in the absorption and disposition of many compounds. The purpose of this study was to investigate the possible interaction of P-gp with each of four major marijuana constituents...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov



www.nature.com

The Differential Binding of Antipsychotic Drugs to the ABC Transporter P-Glycoprotein Predicts Cannabinoid–Antipsychotic Drug Interactions - Neuropsychopharmacology

Cannabis use increases rates of psychotic relapse and treatment failure in schizophrenia patients. Clinical studies suggest that cannabis use reduces the efficacy of antipsychotic drugs, but there has been no direct demonstration of this in a controlled study. The present study demonstrates that...
www.nature.com www.nature.com


THC/WEED P-GP

@herbertadams
 
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herbertadams said:
Perhaps dopamine receptors don't upregulate much and perhaps you wouldn't want them too.

But taking antipsychotics long term and antagonising the receptors will cause upregulation. -this is obviously not a good idea.

Perhaps the goal is to simply recycle the old receptors and grow new neurotransmitters. Perhaps nsi189 could prove useful although there are ancedotal reports of it causing lasting anhedonia. So best to avoid given current symptoms.

Perhaps the beginning supplementing dopamine production with l tyrosine or similar could be a point of research, if this is a success then perhaps 9-ME-BC and a 2 week on 4 week off regiment could be worth researching.

Perhaps also Choline could be worth looking into.
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I want them to upregulate. I feel very horrible, living is hell. Are there any more drug that can upregulate dopamine receptors
 
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