If your receptors were destroyed you wouldn’t be able to function, your dopamine receptors recycle. There’s no such thing is having destroyed dopamine receptors. Your brain doesn’t know how to respond with dopamine, it’s proven in people have drug abuse problems that can’t experience happiness and motivation. They can receive the same amount of dopamine as a normal person after recovery, but the receptors have been flood for a long time once they don’t have the same amount of dopamine there brains don’t what to do. Same theory goes to people who they receptors blocked for some time and are receiving no dopamine, once you reach normal levels of dopamine, your receptors doesn’t know how to react to it.