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Mental Health Coming off Invega Sustenna (Paliperidone) v3

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ihateinvega said:
I don't know. If the person only has 3% body fat, I think a smaller amount of the Invega may be stored in their fat than someone who has a larger amount of body fat.

Based on the things I've read, the amount of body fat someone has can play a role in recovery. I think that exercising and losing weight can speed up the process of recovery. Be careful about getting too low of a body fat percentage though, that could alarm someone, especially if you start looking like a skeleton. It may be good to get down to a lean size that looks normal, and exercise to burn fat and then gain it back. So like, lose one pound of fat and gain one pound of fat, and rinse and repeat. I think if you do it enough, your body will expel the rest of the Invega that's stored in your fat until there's no drug or very little left in your fat.
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I already am a lean person, so I don't have like a lot of fat to lose, just the fat that has absorbed the drug. I don't know if losing one pound of fat, gaining it back, losing and repeating the whole process will get the drug out of my system, because I can be constantly losing the same part of fat that doesn't have the drug stored in it. I think losing the whole amount of fat to the point I'm about 4% BF would be a better idea, cause then I'd be sure I got rid of a lot of the substance. I once weighed 48kg and I looked really skinny, but not to the point that I'd be called anorectic all the time. 99.5% of the time I stay at home anyway now. I can lose weight very easily, so once I'll weigh around 50kg, I'll start eating like an animal, so I'll get my 60kg mark back as quickly as possible. This whole process shouldn't take me a lot of time and I think it's the only effective way.

In fact, I'm lucky that I haven't gained fat on my Abilify Maintena. If I gained a lot of fat because of the drug, then it would be difficult as hell to get rid of it by burning fat. Let's say I have to burn 5kg of fat to cleanse the body from 50% of the drug. Someone else might have to lose 20kg to lose the same amount of it. I regret I didn't start to lose my weight months ago, so I'd recover even faster, because by that time I'd have lost much more of the drug. Though I probably would of died if I was to remove, let's say, 200 of 400mg stored in fat (or 50 of 100mg, because according to the graph available on the Internet, one single dose of 400mg causes the Cmax of 100mg) in a month or so, the amount of the drug moved to my brain because of this process would be huge. If I have by now around 20mg out of 400 given at the beginning, after my weigh loss I'll have maybe a bit less than 10mg if I'm not mistaken. It's always something.
 
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Invegastolemysoul said:
I would be surprised if and invega is still even in my system anymore but it still has the receptors blocked anyway .I've improved maybe 15% in the last 2 1/2 years and I'm 6 foot tall 175lbs I'm happy again finally and a few months ago started jogging . I cant feel pot or alcohol or cigarettes or caffeine. but I'm seriously used to it now and life is good. I'm I'm a good marriage and I've been married for a year. I believe my soul is finally coming back into my body after so many years.
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Yeah it’s weird man. I could get buzzed from nicotine just a few days ago and now I can’t
 
Hey guys good to see some positive vibes in here. Keep being patient and you will recover for sure like I did a few years ago. It only took me 6 months but might take you a bit longer depending on how many shots you had.

Just stay positive guys!
 
mrwelladjusted said:
I already am a lean person, so I don't have like a lot of fat to lose, just the fat that has absorbed the drug. I don't know if losing one pound of fat, gaining it back, losing and repeating the whole process will get the drug out of my system, because I can be constantly losing the same part of fat that doesn't have the drug stored in it. I think losing the whole amount of fat to the point I'm about 4% BF would be a better idea, cause then I'd be sure I got rid of a lot of the substance. I once weighed 48kg and I looked really skinny, but not to the point that I'd be called anorectic all the time. 99.5% of the time I stay at home anyway now. I can lose weight very easily, so once I'll weigh around 50kg, I'll start eating like an animal, so I'll get my 60kg mark back as quickly as possible. This whole process shouldn't take me a lot of time and I think it's the only effective way.

In fact, I'm lucky that I haven't gained fat on my Abilify Maintena. If I gained a lot of fat because of the drug, then it would be difficult as hell to get rid of it by burning fat. Let's say I have to burn 5kg of fat to cleanse the body from 50% of the drug. Someone else might have to lose 20kg to lose the same amount of it. I regret I didn't start to lose my weight months ago, so I'd recover even faster, because by that time I'd have lost much more of the drug. Though I probably would of died if I was to remove, let's say, 200 of 400mg stored in fat (or 50 of 100mg, because according to the graph available on the Internet, one single dose of 400mg causes the Cmax of 100mg) in a month or so, the amount of the drug moved to my brain because of this process would be huge. If I have by now around 20mg out of 400 given at the beginning, after my weigh loss I'll have maybe a bit less than 10mg if I'm not mistaken. It's always something.
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Since you're not on Invega Sustenna, you should look up whether the drug you took can store in fat like Invega. You may not even have to lose any weight.

As far as whether losing and gaining weight like I mentioned would work to clear the drug out of your system, well, I'm not sure but I think it would. I guess it depends on how your body burns fat. Like, would your body burn the oldest fat first? I'm not sure. I still think it would work though, but I could be wrong.
 
ihateinvega said:
Since you're not on Invega Sustenna, you should look up whether the drug you took can store in fat like Invega. You may not even have to lose any weight.

As far as whether losing and gaining weight like I mentioned would work to clear the drug out of your system, well, I'm not sure but I think it would. I guess it depends on how your body burns fat. Like, would your body burn the oldest fat first? I'm not sure. I still think it would work though, but I could be wrong.
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I'm pretty sure every LAI like Invega and Maintena are stored in fat tissues, there's no any other option.
That's why I want to get as lean as possible, so I'll be sure that I did everything I could to get as much fat and the drug in it cleansed out of the body. I don't know if I'll burn fat containing the drug first, so I'll just burn as much fat as I can. Then I'll slowly get my weight back, so I don't get stretch marks etc.

That's what I found:

Distribution
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Based on results from trials with oral administration of aripiprazole, aripiprazole is widely distributed throughout the body with an apparent volume of distribution of 4.9 l/kg, indicating extensive extravascular distribution. At therapeutic concentrations, aripiprazole and dehydro-aripiprazole are greater than 99 % bound to serum proteins, binding primarily to albumin.
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And I don't know what to think about this. Maybe someone can catch the meaning of this and explain in simpler words.
Absorption Aripiprazole absorption into the systemic circulation is slow and prolonged following Abilify Maintena administration due to low solubility of aripiprazole particles.The average absorption half-life of Abilify Maintena is 28 days. Absorption of aripiprazole from the IM depot formulation was complete relative to the IM standard (immediate-release) formulation. The dose adjusted Cmax values for the depot formulation were approximately 5 % of Cmax from IM standard formulation.Following a single dose administration of Abilify Maintena in the deltoid and gluteal muscle, the extent of absorption (AUC) was similar for both injection sites, but the rate of absorption (Cmax) was higher following administration to the deltoid muscle. Following multiple intramuscular doses, the plasma concentrations of aripiprazole gradually rise to a maximum plasma concentration at a median tmax of 7 days for the gluteal muscle and 4 days for the deltoid muscle. Steady state concentrations for the typical subject were attained by the fourth dose for both sites of administration. Less than dose-proportional increases in aripiprazole and dehydro-aripiprazole concentrations and AUC parameters are observed after monthly Abilify Maintena injections of 300 mg to 400 mg
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And how do you know Invega is stored in fat? How can I know if Abilify Maintena could be stored in fat? Someone enlighten me, please, cause I don't want to lose 7 kilogrammes and then learn that it all was pointless. Aripiprazole is mostly excreted with poop, so maybe I should poop more? Lol. More fiber in my diet or something.
 
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mrwelladjusted said:
I'm pretty sure every LAI like Invega and Maintena are stored in fat tissues, there's no any other option.
That's why I want to get as lean as possible, so I'll be sure that I did everything I could to get as much fat and the drug in it cleansed out of the body. I don't know if I'll burn fat containing the drug first, so I'll just burn as much fat as I can. Then I'll slowly get my weight back, so I don't get stretch marks etc.

That's what I found:



And I don't know what to think about this. Maybe someone can catch the meaning of this and explain in simpler words.


And how do you know Invega is stored in fat? How can I know if Abilify Maintena could be stored in fat? Someone enlighten me, please, cause I don't want to lose 7 kilogrammes and then learn that it all was pointless. Aripiprazole is mostly excreted with poop, so maybe I should poop more? Lol. More fiber in my diet or something.
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Well, I'm very certain that some Invega Sustenna is stored in fat for most people who receive it, but I guess I don't know that. I think I learned about that from people in this thread (and maybe the other "Coming off Invega Sustenna" threads) including from one user named PhucInvega. I think you should look him up, I think his posts contain insight that could be helpful.

I've read an article that said weight can impact the drug's duration. I also read a post from a user in this thread who claimed that he re-experienced the effects of Invega for a few weeks after going for a run or something. I think that makes it pretty clear that the drug can store in fat, because the drug was probably re-released into his system after he burned fat that had Invega in it while exercising. It makes sense, you know? Why else would he have re-experienced the effects of Invega after exercising?
 
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ihateinvega said:
Well, I'm very certain that some Invega Sustenna is stored in fat for most people who receive it, but I guess I don't know that. I think I learned about that from people in this thread (and maybe the other "Coming off Invega Sustenna" threads) including from one user named PhucInvega. I think you should look him up, I think his posts contain insight that could be helpful.

I've read an article that said weight can impact the drug's duration. I also read a post from a user in this thread who claimed that he re-experienced the effects of Invega for a few weeks after going for a run or something. I think that makes it pretty clear that the drug can store in fat, because the drug was probably re-released into his system after he burned fat that had Invega in it while exercising. It makes sense, you know? Why else would he have re-experienced the effects of Invega after exercising?
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Yeah, I've read about that guy who went for a run and that he re-experienced those effects of Invega for a few weeks. My concern is that this may as well happen to me if one day I get better, because I'm a very active person (at least I used to pre-Abilify), I'd like to go to a gym when I'll be ready to exercise. So my guess is that lowering my body fat to the lowest possible amount that would keep me healthy and alive (something around 4, 5% ) will ensure me that I will never experience side effects once I recover. Does losing most of my fat reassure me that there will be much less of the drug in my system? I don't know. But even getting 20% of it out of my body would be a huge success.

But it makes me wonder, is most of the drug stored in fat or is it stored anywhere else? If so, where then?

Oh, and I've read posts of PhucInvega, he really does provide important informations for us. I read this forum almost on a daily basis, so I know that I haven't missed something that could help me, lol.

That's what I found on the Internet:

Some drugs accumulate in certain tissues (for example, digoxin accumulates in heart and skeletal muscles), which can also act as reservoirs of extra drug. These tissues slowly release the drug into the bloodstream, keeping blood levels of the drug from decreasing rapidly and thereby prolonging the effect of the drug. Some drugs, such as those that accumulate in fatty tissues, leave the tissues so slowly that they circulate in the bloodstream for days after a person has stopped taking the drug.

Distribution of a drug may also vary from person to person. For instance, obese people may store large amounts of fat-soluble drugs, whereas very thin people may store relatively little. Older people, even when thin, may store large amounts of fat-soluble drugs because the proportion of body fat increases with age.
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I think I'm gonna buy myself a St. John's Wort. It's a P-gp inducer and aripiprazole (Abilify) seems to be a P-gp subtrate. Maybe it will work? That I don't know. I just don't want my propranolol to stop working due to the use of St. John's Wort, I must take beta-blockers.. hmm
 
I just bought a Jarsin 300 St. John's Wort, which cost me almost 50 euros, Jesus. I mean, you can have lunch for 50 euros and you can think it's nothing, but for a broke kid like me it's fucking a lot xD and it's coming from Germany, I wonder when it'll arrive. Can't wait. If it won't make me feel better or if it even will make me feel worse, I don't care. I'll know that at least I've tried everything I could. Losing weight + a solid SJW is pretty much everything I can do. And eat a lot of rye bread and vegetables, so I can poop 5 times a day, drink a lot of water, so I can piss every 15 minutes. I can't blame myself for not doing anything to get better.
 
should someone that only got 1 shot expect a shorter recovery window then dominated got many 10+.?
Hownwouldbthat work in terms of drug elimination
 
Sbar25 said:
should someone that only got 1 shot expect a shorter recovery window then dominated got many 10+.?
Hownwouldbthat work in terms of drug elimination
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You can view what a single dose curve looks like by agreeing to the terms and customizing the dose at https://www.educationaldoseillustrator.com/pp1m/schizophrenia/scenario/single-dose-curve-view
I would imagine it would take more than 10 months to fully recover. I would take into consideration the invega that is stored in fat that would have to be removed to. I think if you spent time exercising and burning the fat, that invega could be stored in, the sooner the invega will be gone. Eventually, the invega that is in your fat will need to be burned off to fully recover. So the best thing to do I would imagine is just to burn off the fat now, rather than 10 months later, so you don’t have to wait another 10 months. For me, the smallest dose of an antipsychotic has a drastic effect on me, so you might want to be sure none of the invega is left.
Something I worry about is that because invega causes weight gain, any invega released from the burned fat will cause further weight gain making it more difficult to burn off the fat that invega is stored in. I fear of a cycle of burning fat and then gaining more due to the release of invega and then having to burn more fat that is less concentrated with invega, only for it to repeat. I’m not entirely sure about this but it is something that could be possible.
To more directly answer your question, I believe people with more shots have more invega stored in their fat causing it to take longer for the invega to be completely removed from the body. Also, because they have multiple shots, the overall peak concentrations are higher than someone who had only one shot. This is because they are injected again on a concentration higher than baseline from the previous shot. So yes, someone with only 1 shot should expect a shorter recovery compared to someone who had multiple.
 
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I increased my dosage of St John’s Wort and I couldn’t sleep last night. It really works, not being able to sleep is a sign the antipsychotics are wearing off for me.
 
I'd like to mention something in this thread. While I think it's a good idea for most people who have been on this drug to lose fat and exercise to get the drug out of their system and recover, I think it may not be necessary for some people to recover. I mean, there have been people who have posted about their recovery in this thread, and I'm pretty sure some of them didn't go out of their way to burn fat and exercise to get the drug out of their system. I think some people didn't do that and recovered anyways.

So is losing fat necessary to recover from this drug? Well, I'm not sure, but it may not be for some people. However, some of those who have recovered and didn't burn fat and/or exercise to get the drug out of their system may experience the effects of Invega again in the future if they burn fat.

So while it may not be necessary to lose fat to recover from this drug, when it comes to me personally, I would rather lose fat to try to get this drug out of my body than take my chances when it comes to re-experiencing the effects of Invega further down the line. I think that's what I would recommend for most people. I want this drug out of my system. I don't want to leave significant (significant enough to be effective) quantities of the drug in my fat to be re-experienced later on.
 
I'm giving it 5 years for 1 single dose shot if I don't feel better idk anymore.
So dopamine receptors regrow do serotonin receptors regrow one would think once he medication is fully gone the brain would start heading in the recovery dorection
 
Here's a post with a list of recoveries and times it took to recover:
"https://www.bluelight.org/xf/thread...-paliperidone-v3.861790/page-43#post-14571463"

I think it may be the latest list that there is. Would someone here be willing to update this list and keep it updated over time? I think it would be nice to have.
Sbar25 said:
I'm giving it 5 years for 1 single dose shot if I don't feel better idk anymore.
So dopamine receptors regrow do serotonin receptors regrow one would think once he medication is fully gone the brain would start heading in the recovery dorection
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Look at the post I posted above. It says that the average recovery time for 1 shot is 10.5 months.
 
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