Does anyone know anything about the changes to biochemistry and if it is permanent. some said once antagonist irreversible receptor it doesn't come back? Who knows anything about humans this.
Paliperidone is not an irreversible antagonist, it will bind and dissociate like any other. It does have a very high affinity for dopamine receptors and a long half life though, so it just
seems like it lasts forever.
However, even compounds that
are irreversible antagonists don't produce permanent effects. After a while your body will recycle the receptors that have been permanently activated (or deactivated), as part of the normal housekeeping and regenration your body does. This can take a long time, on the order of a few months, before all receptors are totally restored.
Do you know if lifeline ever recovered from invega?
I would imagine that he did, but that's because I'm being optimistic
It seems to me that basically everyone who has dealt with the awful effects of Invega will recover to a functional state. It's not going to happen overnight, but it will happen gradually. I think it will actually help if you try convincing yourself you
can get through this - a positive attitude sounds cheesy but it's proven to help people recover from almost any major disruption in life. It certainly does the mind better than ruminating on why you don't deserve to feel good. Those thoughts don't do anything but drag you down.
I can’t make it. I know I can’t.
Take it one day at a time. You have made it this far, and things aren't getting any worse, are they? I know you have it in you to conquer this demon and come out a better person.
Here's an experiment I try with people who experience mental "damage" from drugs: try coming up with a list of things you have done that make you feel good, and things you
could do to make your life better, even simple ones. Even if you have only done basic tasks like shopping or having a shower, congratulate yourself for being able to do it. You may find that you are capable of a lot more than you give yourself credit for. And doing simple things to make you feel good not only focuses your mind on constructive, positive thinking, but also helps retrain your nucleus accumbens (the reward center of the brain) to feel good about things that benefit you. One of the effects of antipsychotics is that they will reduce signalling in this reward/pleasure area, so things that used to engage you, now feel dull and joyless, and positive thinking / exercise / gameplay / joking / music / sex / daydreaming, etc all will help restore your sensitivity to dopamine.
