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Mental Health Coming off Invega (Paliperidone, Xeplion) injections v 6.0

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Serhat96 said:
Takes about 5 month for the paliperidone to dissolve away in the brain from what I read, you should see improvements in the coming months.
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I hope that's true.
I've read somewhere that it takes dopamine receptors 14 months to heal.
This drug does way more damage than just blocking some dopamine receptors.
Why is my mind blank when I try to think?
Why is it hard for me to reach deep conclusions?
How blocking dopamine receptors does that to you?
Nothing is exciting or magical anymore...
 
UnluckyXeplion said:
I hope that's true.
I've read somewhere that it takes dopamine receptors 14 months to heal.
This drug does way more damage than just blocking some dopamine receptors.
Why is my mind blank when I try to think?
Why is it hard for me to reach deep conclusions?
How blocking dopamine receptors does that to you?
Nothing is exciting or magical anymore...
Click to expand...
I feel you I'm in the same situation but 14 months thats probably heal time recovering from recreational drugs, let say you took heroin for 10 months thats most likely going to destroy your receptors and its going to take a long time to heal
 
Serhat96 said:
I feel you I'm in the same situation but 14 months thats probably heal time recovering from recreational drugs, let say you took heroin for 10 months thats most likely going to destroy your receptors and its going to take a long time to heal
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I prefer heroin than invega lol
Invega/Xeplion damages receptors differently I guess.
How can't people feel weed after this drug? that's a proof that it blocks CB1 receptors as well.
 
UnluckyXeplion said:
I prefer heroin than invega lol
Invega/Xeplion damages receptors differently I guess.
How can't people feel weed after this drug? that's a proof that it blocks CB1 receptors as well.
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One conclusion why people can't feel the effects of marijuana is because what Invega does is, it creats the opposite effects of weed, so when you smoke it while being on Invega it cancels eachother out, think of a balance scale of highness, on invega you are at -50, when you're not on Invega your high is +50, when you take weed while been on Invega your high scale is 0. Does that make sense abit? Cause virtually what this injection does is gives the opposite effects of recreational drugs.

Invega has anti-psychoactive effects in the brain.
 
Serhat96 said:
Yeah same I got about 8-9 shots funny thing is I'm still on the injection my last shot was on 16/12/2022.
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What was ur issue ...psychosis or mania? Zyprexa suckass tho...i know it well...makes u dumb makes u fat...its been 18 plus months since my last injection there is a lot pf improvements i think...less anhedonia, less depression...and havent relapsed yet..thats was my main concern , things will improve dont worry...time heals.
 
Risingson8 said:
What was ur issue ...psychosis or mania? Zyprexa suckass tho...i know it well...makes u dumb makes u fat...its been 18 plus months since my last injection there is a lot pf improvements i think...less anhedonia, less depression...and havent relapsed yet..thats was my main concern , things will improve dont worry...time heals.
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Both psychosis and mania, I was diagnosed with schizoaffective disorder 9 months ago, been on the injection for 9 months finally quitting it at 75mg dosage. Good to hear you havent relapsed well done!
 
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Serhat96 said:
One conclusion why people can't feel the effects of marijuana is because what Invega does is, it creats the opposite effects of weed, so when you smoke it while being on Invega it cancels eachother out, think of a balance scale of highness, on invega you are at -50, when you're not on Invega your high is +50, when you take weed while been on Invega your high scale is 0. Does that make sense abit? Cause virtually what this injection does is gives the opposite effects of recreational drugs.

Invega has anti-psychoactive effects in the brain.
Click to expand...
That's what I said today haha.
 
I read that antipsychotics cause brain shrinkage due to loss of grey matter in the prefrontal cortex, the part responsible for cognition and creativity and also having the highest density of dopamine receptors.
The prefrontal cortex (PFC) is the cerebral cortex covering the front part of the frontal lobe. This brain region has been implicated in planning complex cognitive behavior, personality expression, decision making, and moderating social behaviour. The basic activity of this brain region is considered to be orchestration of thoughts and actions in accordance with internal goals.
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I think this might explain some of the loss of creativity, personality, motivation and deep thinking due to Invega as the brain is literally losing its network of connections by shrinking them.

A person with damage to the prefrontal cortex might have blunted emotional responses, for instance. They might even become more aggressive and irritable, and struggle to initiate activities. Finally, they might perform poorly on tasks that require long-term planning and impulse inhibition.
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What do you all think about this? Does the brain ever recover its lost grey matter?
 
StrawHatLuffy said:
I read that antipsychotics cause brain shrinkage due to loss of grey matter in the prefrontal cortex, the part responsible for cognition and creativity and also having the highest density of dopamine receptors.

I think this might explain some of the loss of creativity, personality, motivation and deep thinking due to Invega as the brain is literally losing its network of connections by shrinking them.



What do you all think about this? Does the brain ever recover its lost grey matter?
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Yeah It does recover before Invega I was on Olanzapine 10mg works the same way as Invega, I was on Olanzapine for 3 months I quit cold turkey and I was back to normal in 3-4 weeks. Your brain eventually recovers and gets back normal just a matter of time really however with the injection it may take 4-5 months cause of the half life. The brain is incredibly resilient and possesses the ability to repair itself through the process of neuroplasticity.
 
Serhat96 said:
I feel you I'm in the same situation but 14 months thats probably heal time recovering from recreational drugs, let say you took heroin for 10 months thats most likely going to destroy your receptors and its going to take a long time to heal
Click to expand...
I never taken recreational drugs or alcohol before invega and after invega. I'm above 1.5 years off invega and around half recovered, at 1 year off I was around 40% recovered. Invega deforms receptors proteins (making them less effective or completely useless) and also have damaging effect on synapse structures. It also has irreversable antagonism on some receptors which requires body to absorb the receptor and rebuild it. It is slow recovery but you will gradually improve.
 
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t_xeplionhell said:
/I never taken recreational drugs or alcohol before invega. I'm above 1.5 years off invega and around half recovered, at 1 year off I was around 40% recovered. Invega deforms receptors proteins (making them less effective or completely useless) and also have damaging effect on synapse structures. It also has irreversable antagonism on some receptors which requires body to absorb the receptor and rebuild it. It is slow recovery but you will gradually improve.
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When you say half recovered what are the lingering effects you are still having?
 
Serhat96 said:
When you say half recovered what are the lingering effects you are still having?
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Anhedonia and numbness to all kind of experiences. Less able to visualise. My memory is also less efficient. I still notice those stuff improving slowly.
 
Hello I posted here under a different name in the summer/spring of 2021.

I got my first injection at the end of winter and went back into psychosis fall of 2021.
Thing is, just a few days before I went into my psychosis I was heavily Mandela affected - album logos changed, lyrics changed. At the day my psychosis started, the whole world felt dreamlike and meant only for me. My mothers eyes were beautiful. Other eyes were spinning. After that day, the people in the ward were upset and I asked 1 man if he ever went to church. He responded in such a way I thought I should head to church. So I did, but I didn’t have the freedoms yet and when they wanted to pick me up, I ran in front of cars. However, inside the church was 1 creepy dude and 2 women who’s eyes were spinning. The music was beautiful and I was touched by Jesus energy, which made me believe I was a god/the messiah. When I got removed from church, they said “they’re boss here”. I thought I was in the middle of a battle between good and evil.

Sure enough, they started me on Zyprexa tablets which I refused and they injected me every night. This went on for three months before I tried to escape and commit suicide. That’s when they moved me to another mental hospital. Here they started Abilify. They also started Concerta. After some time there lots of crazy stuff happened, including people who heard the same voice, someone who knew about my repeating childhood nightmares, NURSES NEXT DOOR VOCALIZING MY THOUGHTS.

They also said to me they cracked the algorithm or whatever. One nurse held the door and said he OP’d me. Other patients were distressed. They always looked / reacted to me like I had done something vile.

Anyway, one day they drew blood against my will. The next day, they transferred me to a Medical Psychiatric Unit saying I was catatonic (I wasn’t). Here I saw a psychiatrist and a doctor assistant, and they started me on Haloperidol, Promethazine and continued the Ativan on my old dosage.

When I got fired from hospital, they lied to the mental health workers that they used high doses Ativan (they never did.) This was in summer of 22. I started getting Mandela effects more often (signs, artwork appearing out of nowhere, or changing.)

I’m now on 2mg of Haldol and promethazine and Ativan.

When I got my first injection in March ‘21, all I could focus on was my reduced life experience and it made me suicidal. That’s when I got committed again and started a journey where I don’t know what happened at all and made me afraid- but physically I am unable to experience fear.
 
Whathappened123 said:
Hello I posted here under a different name in the summer/spring of 2021.

I got my first injection at the end of winter and went back into psychosis fall of 2021.
Thing is, just a few days before I went into my psychosis I was heavily Mandela affected - album logos changed, lyrics changed. At the day my psychosis started, the whole world felt dreamlike and meant only for me. My mothers eyes were beautiful. Other eyes were spinning. After that day, the people in the ward were upset and I asked 1 man if he ever went to church. He responded in such a way I thought I should head to church. So I did, but I didn’t have the freedoms yet and when they wanted to pick me up, I ran in front of cars. However, inside the church was 1 creepy dude and 2 women who’s eyes were spinning. The music was beautiful and I was touched by Jesus energy, which made me believe I was a god/the messiah. When I got removed from church, they said “they’re boss here”. I thought I was in the middle of a battle between good and evil.

Sure enough, they started me on Zyprexa tablets which I refused and they injected me every night. This went on for three months before I tried to escape and commit suicide. That’s when they moved me to another mental hospital. Here they started Abilify. They also started Concerta. After some time there lots of crazy stuff happened, including people who heard the same voice, someone who knew about my repeating childhood nightmares, NURSES NEXT DOOR VOCALIZING MY THOUGHTS.

They also said to me they cracked the algorithm or whatever. One nurse held the door and said he OP’d me. Other patients were distressed. They always looked / reacted to me like I had done something vile.

Anyway, one day they drew blood against my will. The next day, they transferred me to a Medical Psychiatric Unit saying I was catatonic (I wasn’t). Here I saw a psychiatrist and a doctor assistant, and they started me on Haloperidol, Promethazine and continued the Ativan on my old dosage.

When I got fired from hospital, they lied to the mental health workers that they used high doses Ativan (they never did.) This was in summer of 22. I started getting Mandela effects more often (signs, artwork appearing out of nowhere, or changing.)

I’m now on 2mg of Haldol and promethazine and Ativan.

When I got my first injection in March ‘21, all I could focus on was my reduced life experience and it made me suicidal. That’s when I got committed again and started a journey where I don’t know what happened at all and made me afraid- but physically I am unable to experience fear.
Click to expand...
Do you know what got you in such state.
 
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