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  • Trip Reports Moderator: Cheshire_Kat | M!$ter-ED

Combo 2C-B and 2C-D (7mg each)

Didgital

Bluelight Crew
Joined
Jul 22, 2018
Messages
1,603
Location
Colorado, USA
Ok..

So I've been wanting to explore this combination for some time. Just to note I have combined 2C-E with 2C-B before and while that was a crazy psychedelic experience, since then I've learned that the 4 alkyl 2C's do exhibit some MAOi properties. So this experience was planned taking that in consideration. I'm not encouraging my behavior, only documenting it for future reference and HR knowledge. AFAIK there's no reports of this combo and it's possible that high doses of each could lead to serious medical problems.

T+0:00 I measured 7-8mg of each separately (my scale is a $100 mg scale so.. exact dosage is more of a range especially when weighing super low doses. It won't register less than 5mg. But i was as careful as I could be with the equipment I had.
Both were placed on tongue simultaneously and washed down w H2O.

T+ 0:05 Went for a walk on a beautiful spring day to the local coffee shop. En route, encountered several dog walkers, I was cheery/friendly on each interaction (as were others) even to a certain group of individuals sitting in a yard chainsmoking and drinking miller highlife. It's 11am not that I'm judging too hard. I'm a hippy, they are not. Eye contact, a polite nod is all that is done and reciprocated.

Get to coffeehouse where I joke with the employees about their IASIP ringtone, I ate a slice of greasy but tasty pizza, had a few sips of coffee but not enough to significantly affect the experience IMO. I get the coffee to go.

T+0:30 the effects started to present themselves somewhat rather strongly and quickly. Probably at the same speed that I would detect B, but with increased frequency/intensity. Notice a fine tremor in my hand, I get this with 2CD but not 2CB, i chalk it up to exhilaration, and while I'm getting clear visual effects it's hard to define. Again my doses were not high. I also notice I feel effects of 2C-B quicker than most, and especially if I'm being physically active. Maybe increased bloodflow makes it hit harder. I've always believed that.

At 7mg of 2C-B I would feel something for sure very lightly.
at 7mg of 2C-D i could say the same, except even lighter than 2C-B.

I feel like this is stronger than 14mg of either would be alone. comparable to 20-22mg of 2C-B or 30-35mg of 2C-D.

My walk home, I am noticing colors a lot more vividly, my visual field is kind of swimming/looking underwater, but not getting overt visuals necessarily. Still I am very careful to keep my interactions this time very minimal. To the same group, this time there is no eye contact, the same polite nod, no reciprocation, not that i care. Keep walking. Don't make eye contact. Be friendly but keep moving.

T+1:00 - I've arrived back home, I see several text messages and calls, but tbh I don't want to respond to anything. I definitely do not want to talk on the phone. I am reminded somewhat of 2C-E, with less of a body load.

T+ 2:00-3:00 approximately I watch an Ai generated scifi shortfilm called the Patchwright. It's disturbing but extremely visual and somewhat thought provoking. Reminds me a bit of something of Love Death Robots, except on the creepier, skin crawilier end of the spectrum. Not what I would recommend watching while tripping to most people, though I am pretty into crazy films. Even I am a bit asking why did I put this on? (to be fair i didn't know it was going to be so creepy)

T+4:00 - It's starting to settle down a bit. The first few hours I felt like I was constantly coming on to something but tripping also. It wasn't as smooth as 2C-B or 2C-D alone. Physically it was closer to 2C-D, visually it was closer to 2C-B, but also sort of a hybrid of each (big surprise) I'm thinking about responding to actual phone calls, but I'm not ready yet.

T+5:00 I'm starting to feel a bit steadier and the visual aspect is still present but not easy to define. I figure maybe I should do some chores I been neglecting starting with my dirty sink and dishes. But visually I'm a bit grossed out. Details look incredibly sharp. Dishes can wait, I head back to my room also kind of a mess, maybe I can start with this instead. Physically, feeling a lot smoother. There were moments of queeziness but I get that with 2C-D alone, and the greasy pizza probably didn't help. I imagine by T+7:00 ill be at baseline with 2c afterglow. Expecting to sleep normally.

While, I don't think this experience is a glowing fantastic experience that I will try and recreate any time soon. It has confirmed kind of what I thought would happen. The two substances synergize into something more than either alone would be. If I only had 7mg of 2C-B and I only had 7mg of 2C-D and I wanted a solid psychedelic experience, then I would combine them. Otherwise, I think in the future I'll be taking them separately. If I did combine them in future, not sure what dosages I would choose. either up them both evenly for a more intense but similar experience. Up the D for a deeper but stimulating experience, or Up the B for a more visual experience. Not sure yet what I would do..


Note- This was written Live. I may come back and edit it later, but I'm pretty sure Im confident how the rest of the trip will proceed.

I do want to eventually combine 2C-D with small amount of MDMA, tho I'm not sure how I plan on taking them (what order, when etc)

Thanks for listening, Bee safe!
 
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2C-B also has some MAO inhibition, but I don't really think this is relevant at those low dosages. But I would not have expected the two to synergise so much. I've thought about doing this combo to add some of the warmth of 2C-B into the neutral 2C-D and some of that analytical-introspective headspace of 2C-D into 2C-B. Does this work? Thanks for your report :)
 
2C-B also has some MAO inhibition, but I don't really think this is relevant at those low dosages. But I would not have expected the two to synergise so much. I've thought about doing this combo to add some of the warmth of 2C-B into the neutral 2C-D and some of that analytical-introspective headspace of 2C-D into 2C-B. Does this work? Thanks for your report :)
Really? I did not know that about 2C-B.

Certainly it was not like taking 2C-B and 2C-E which was amazing and one of the more visual phenethylamine experiences of my life, but actually caused very noticeable and worrisome vasoconstriction, so I was def a bit careful even knowing that 2C-D is a lot weaker on all fronts. Ya know, the 2C-B did not really add much warmth in this case. Set and setting though. I do think if I was out at a concert, the lights and sound would have been extra beautiful.

As far as headspace, it was quite a blend of both. I don't really get much headspace with B, until I hit what I call high dose, but it was also different than 2C-D alone which I generally find very clear and even dare I say serene. I remember, while I was watching the short sci fi, I was kind of freaking out mentally. Not in a bad way, but I was WTF AM I WATCHING. OMG OMG.

Hard to explain, probably shoulda taken slightly higher doses of each, but I've got a lot going in life rn so I kept dose very exploratory. I'm not always trying to go to space especially with relatively unknown combo.

My main discovery was that they would synergize and I think they did. Like i said 14mg of either alone, I consider pretty darn light. 14 of the D i still consider a mini dose. I could take that dose and go to work easily. On this occasion, I didn't even want to talk to anyone on the phone. I ignored calls till prolly hour 5 or 6.
14 of B I'm starting to feel like it's an actual trip, but still pretty light. I was surprised, the first few hours were more intense than I expected.

As I predicted, around hr 6 there was a very steep drop off, and by 7 hrs I felt basically normal w nice little afterglow.

Here is the creepy sci fi short if anyone was curious.

 
I'm surprised you started with a 1:1 ratio given that 2C-D seems less potent than 2C-B by weight. Perhaps 1:1.6 might be a bit closer to an even balance? As such, I would expect the effects of your combo to lean into the 2C-B.

The potentiation is interesting, but I think it's a stretch to attribute it to effects on MAO. Can you provide a source for the info that 2C-alks are MAOIs? I think technically just about any substrate for MAO could be considered a REMI, but the degree of inhibition is likely to be very low unless the drug occupies the enzyme for a long time for some reason. The other thing though is that if 7 mg 2C-D blocks MAO enough to potentiate 7 mg 2C-B, then I would expect it to similarly potentiate AN ADDITIONAL 7 mg of 2C-D. But of course 2C-D is still a +2 for many people even at 21 mg.

I think this calls for a repeat experiment. I would volunteer myself, but my health doesn't allow for it right now. Maybe I can try it in a few months if I'm better then. Oh, and I also want to experiment with other 2C-D combos. For some strange reason I'm curious about 2C-D + mushrooms.
 

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Not really relevant, 10 μM is a lot.
 
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I'm surprised you started with a 1:1 ratio given that 2C-D seems less potent than 2C-B by weight. Perhaps 1:1.6 might be a bit closer to an even balance? As such, I would expect the effects of your combo to lean into the 2C-B.

The potentiation is interesting, but I think it's a stretch to attribute it to effects on MAO. Can you provide a source for the info that 2C-alks are MAOIs? I think technically just about any substrate for MAO could be considered a REMI, but the degree of inhibition is likely to be very low unless the drug occupies the enzyme for a long time for some reason. The other thing though is that if 7 mg 2C-D blocks MAO enough to potentiate 7 mg 2C-B, then I would expect it to similarly potentiate AN ADDITIONAL 7 mg of 2C-D. But of course 2C-D is still a +2 for many people even at 21 mg.

I think this calls for a repeat experiment. I would volunteer myself, but my health doesn't allow for it right now. Maybe I can try it in a few months if I'm better then. Oh, and I also want to experiment with other 2C-D combos. For some strange reason I'm curious about 2C-D + mushrooms.
Well, so here is my reasoning for my doses. I have become very very familiar with 2C-D this past year. I've explored how low I can take it and still feel it. While my "smartdrug" dose is probably 9-15mg, I feel it as low as 4mg, just barely. I tried it at 2mg and couldn't feel it all. 2C-B I've actually never taken less than 5, but I can say I feel a shift as low as 5mg. So... that being said I wanted to take doses of each that I knew I would feel alone, but not much more. So I settled on 7-8 of each. Both mini doses if taken separately, and had I taken 14-16 of either alone, I would certainly feel, but not find it strong. So yeah i took "mini" doses of each.

As far as danger, with MAOi activity, I doubt there would be any problems, but I wouldn't want to take ayahuasca and a full dose of 2C-B, because there really isn't a lot of info out there with MAOis and phenethylamines. (I do know someone who takes ayahuasca with Peyote. They say it's fine, but then they also say they've notice a bit of strain on their heart)

I'm generally more sensitive to 2C's than most. Either that or I am so familiar with them, I can identify them in my consciousness before people who are less familiar (generally). I'm also not a huge guy.

There are some out there who believe reverse tolerance is a thing with 2C's, tho I think it has more to do with being able to recognize the drug. I've met many people who take their very 1st dose of 2C-B at 15-25mg, and not feel it hardly. Then they up it 35 or even 45 before they're like "whoa I feel it now". Then... the next time, they typically don't need 45mg to feel it etc.. They'll recognize it at what is considered avg dose.

So yeah.. I just wanted to take mini doses of each, cuz I'm very familiar with each at pretty much all dosage levels, and I wanted to see if they synergize before I really go for a full trip. Not sure I will anyway. I think I prefer them separately.

Kinda unrelated, but I've also taken 2C-I quite a bit and I'm at the point, where I'd rather take 5mg of 2C-I and 10mg of 2C-B than I would take 15mg of 2C-I. I love the compound, but it's just a bit too stimulating.
Super cool paper! I will def be reading this ty!
 
Well, so here is my reasoning for my doses. I have become very very familiar with 2C-D this past year. I've explored how low I can take it and still feel it. While my "smartdrug" dose is probably 9-15mg, I feel it as low as 4mg, just barely. I tried it at 2mg and couldn't feel it all. 2C-B I've actually never taken less than 5, but I can say I feel a shift as low as 5mg.

I've done similar experiments. With 2C-D, I felt nothing at 2.5 mg, but at 5 mg I felt mild effects and experienced a little bit of afterglow the next day. I've felt 2C-B as low as 2 mg, but I doubt I'd notice anything much less than that.

So... that being said I wanted to take doses of each that I knew I would feel alone, but not much more. So I settled on 7-8 of each. Both mini doses if taken separately, and had I taken 14-16 of either alone, I would certainly feel, but not find it strong. So yeah i took "mini" doses of each.

This approach is entirely logical. Though for me 15 mg of 2C-B (not 2C-D) is probably enough for a mild trip.

As far as danger, with MAOi activity, I doubt there would be any problems, but I wouldn't want to take ayahuasca and a full dose of 2C-B, because there really isn't a lot of info out there with MAOis and phenethylamines. (I do know someone who takes ayahuasca with Peyote. They say it's fine, but then they also say they've notice a bit of strain on their heart)

I agree, but I have taken caapi with some cacti (T. terscheckii) a total of three times. In each case, I opted for very low doses of cactus for safety, yet I'm not sure I noticed any potentiation. As such these were very light trips but also felt deeply contemplative and provided long-lasting afterglows. I feel like plain ayahuasca opens me up like a "spiritual MDMA" somehow, making it easier to hear or sense the spiritual in things. The mescaline really brings out the awareness of delicacy and fine detail and provides a wonderful warm "heart energy". The synergy was very special. Perhaps some day I will explore this combo again.

I'm generally more sensitive to 2C's than most. Either that or I am so familiar with them, I can identify them in my consciousness before people who are less familiar (generally). I'm also not a huge guy.

Well as I wrote elsewhere recently, sensitivity can refer to different things. I think I actually have about average sensitivity to phenethylamines in the "normal" range of doses, but I might experience threshold effects at lower doses than most people. Maybe you are similar? Or maybe you are just more sensitive overall, especially with things like 2C-I and 2C-E.

There are some out there who believe reverse tolerance is a thing with 2C's, tho I think it has more to do with being able to recognize the drug. I've met many people who take their very 1st dose of 2C-B at 15-25mg, and not feel it hardly. Then they up it 35 or even 45 before they're like "whoa I feel it now". Then... the next time, they typically don't need 45mg to feel it etc.. They'll recognize it at what is considered avg dose.

Oh yeah, familiarity definitely comes into play here. Most people are maybe used to taking mushrooms and being "hit over the head" compared to the more subtle effects of the 2C-Xs. For me, the mushrooms hit too hard such that even low doses are "anti-social" for me.

Kinda unrelated, but I've also taken 2C-I quite a bit and I'm at the point, where I'd rather take 5mg of 2C-I and 10mg of 2C-B than I would take 15mg of 2C-I. I love the compound, but it's just a bit too stimulating.

In the right setting, that 2C-I simulation can be fun, and the ratio of visuals to mind-fuck is incredibly high. I'm not sure I'd want to combine 2C-I with 2C-B or any other 2C-X. However, I have taken 2C-I with LSD a couple of times, and I enjoyed it quite a lot. I would say the stimulation of the 2C-I and acid were complementary, and each seemed to smooth over the rough edges of the other. Oh and LSD and 2C-E seemed to have a lot of potential, but I only tried that once.
 
Though for me 15 mg of 2C-B (not 2C-D) is probably enough for a mild trip.
Agreed. Light? mild? I don't always know the best words. This combo, I'd still call it light, but like I said, it felt like it was a bit more than what 14mg of either alone would be. Especially the stimulant part. 2C-D i've always felt is mildly speedy, not so much B. But in this case the first 45min well into a few hours, I'd look at my hand and it would just have a very tremor that really never left until the steep comedown. It's probably why I don't think I'll try it again soon. In retrospect, I do think it was more visual than either alone as well. But to me, I wasn't really that interested in them. It was a day trip, and in general 2C visuals aren't the reason I take 2C's (except maybe 2C-T2) so I didn't explore them. I didn't go into my bed in the dark etc. I never really relaxed a whole lot during the trip tbh.
In the right setting, that 2C-I simulation can be fun
Don't get me wrong I love 2C-I, but it gives me something akin to Restless Leg Syndrome that I imagine feels like opioid withdrawl (I wouldn't know). I feel like with a lover I would have a really good time. When I take it with 2C-B as the higher dose, I get the best of both. Way deeper (even scary kinda) visuals, the euphoria, and I don't get the RLS, or skin crawley feeling that I get with a 15mg of 2C-I. In the past when I took full doses of 2C-I, as long as I was doing something and out and about, I never really noticed the stimulation. It was only when I took it home alone that I would get a bit uncomftorable. It's still one of top favs of all time, but it has it's place as do most of these. The 2C-D is generally what I would call the most versatile of them all, which is why I've been exploring it more than most other compounds recently.
Oh and LSD and 2C-E seemed to have a lot of potential,
I did that once, actually my very first time taking 2C-E. I knew what 2C-E was or at least had heard of it, and I stumbled onto it at a festival. I'm not sure what the dose was I believe it was 20mg but this is when I was a total newb. It was in between hour 1 and 2 where I started to get a little nervous and I foolishly said "I should take something that I'm comftorable with" and I popped a tab of really good L. That was a huge mistake. The visuals I got from that... with my eyes closed, I would compare to looking directly at the sun. That's just how bright my closed eye visuals were. I don't think I'll ever do that again. Plus I was hanging around people on LSD/MDMA, who thought I was a bit crazy for taking (to them) a completely unknown substance. I felt a little judged, and I also could barely talk I was very very very high.
 
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It's honestly a great report and I can agree on certain aspects with my very limited experience. I changed my like to a fire.
 
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