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Harm Reduction Combining depressants

N

Ninae

Bluelighter
Joined
Mar 18, 2010
Messages
4,522
I was wondering what are the most dangerous depressants to combine.

I mostly just use depressants and have slipped into a coma many times, from compulsively redosing after benzo amnesia has set in. I rarely combine with alcohol, which I know is most dangerous. But would anyone be able to make a list of what are the most depressing drugs/most dangerous to combine?

Like, I know benzos and opiates is the classic dangerous combination, though less sure about what amounts are dangerous. But what about other depressants, like, say, Lyrica, or Soma. Would Lyrica be more depressing to the nervous system than benzos (as it sure knocks you out harder)? Also, MXE I know is slightly depressing, but a stimulant as well, so I'm guessing not that dangerous. Anyway, some safety guidelines would be appreciated.
 
It's not as cut and dry as you may think. A lot has to do with dosing and individual tolerance, as well as the time frame that you're taking the drugs in question during.

Barbiturates, alcohol, GHB (and related drugs GBL, 1,4-Butanediol) are historically the most potent depressants out there, GABA depressants anyway. There are some opiates and opioids that will kill you if you mixed them with even very low doses of benzos, again, for a non-tolerant person. For example, combining fentanyl (and its analogs), buprenorphine or methadone with benzos or other depressants is very dangerous.

I'd say mixing barbiturates with basically anything is the most dangerous. Barbiturates and alcohol has killed plenty of people. Benzodiazepines are more "forgiving" when it comes to mixing with other depressants, but it is still quite dangerous. Soma is another depressant that is dangerous to mix with benzos, alcohol, opiates, etc. All depressants are dangerous when mixed together. How dangerous depends on many, many factors, as I've said before.

Again, it is very difficult to answer your question because of how vague it is.
 
I know its not that simple and people can get very different results from taking the same doses, etc. that's why I wanted to ask. Apart from type of drugs I was also wondering what size doses are dangerous to mix, like how many benzos you can safely take with how much alcohol, for instance. Also how dangerous are weak opiates like Codeine or UEI (don't know which would be the strongest) to mix with other downers.
 
Lyrica might be kinda bad :/ especially in big doses, since it gets kinda strange on it's own already.
But I've mixed Lyrica with opioids, bupre and methadone to name couple, but rly dont go above 600mg if you decide to mix..
And pop those pill's patiently if your high on opi's already!! Cause your feeling good already, and adding too much can be kinda... ass..
 
Yea, Lyrica must be much worse than Gabapentin. What about Seroquel though? Is that also a dangerous depressant to add into the mix?
 
Ive mixed it with bupe.. Doesnt get any better or potentiate euphoricly maby makes you more "noddy". But im pretty sure it is dangerous
 
I've mixed Seroquel with a few different opiates (low doses of Seroquel, never anything higher than 50mg) and it really just acts like a super powerful antihistamine (very sedating - lots more "nod" as Moe-D mentions).

As far as mixing Seroquel, an opioid/opiate and another depressant goes...I wouldn't do it. It is more dangerous.
 
What about other things you might not think of, but just take for sleep, like Phenibut and Niacin?
 
tried to search for answers and couldn't really find any discussion and this seemed to be the most relevant thread to tag onto to ask a related question about combining GBL/GHB with Soma/Carisoprodol.

I 'm an alcoholic but trying to stop drinking, I regularly combine a lot of CNS drugs, it's not uncommon to have 20mg diazapam + 600mg pregabalin + 1.5-2g soma + 1/2 to 3/4 of a bottle of whiskey all together - I have gaba tolerance issues, please don't mix this shit together it's stupid.

Anyway my pregab tolerance has increased so I'm on a break from it. I don't have a benzo tolerance - but only really enjoy diazapam in combo with other things (CNS or stims). I've cut down soma usage as was getting rebound anxiety when using it too much.

Soma + alcohol is a match made in heaven for me (and generally I limit the booze to a few drinks when I combine), I prefer it to soma + diaz, but I want to stop drinking.

I know it's a dangerous combo, but I'm considering taking Soma with GBL instead of alcohol/benzo.

again I know it's dangerous, but there doesn't seem to be much discussion anywhere on how dangerous and how to safely go about combining the 2. My GBL use is very occasional and generally I like it with stims like mephedrone/coke, but sometimes will take it on it's own - 1.8ml + 0.9ml redosed every hour for a few hours, I never nod out at this amount, if I go any higher I will nod out though.

Should I start with half dose of each and titrate up session by session, or 1g soma and add in a little GBL? truth is if I don't my soma usage is going to increase, or I'm going to keep drinking, or my benzo usage is going to increase.

I'd only be considering doing this once a week max, more likely once a fortnight, I'm trying to go for the effect of 1-2g of soma with a couple of beers here, not half a bottle of whiskey.

@BadBoy377 before you say it, I'm listening and I'm trying to be good honest! baby steps in the right direction
 
Alot was said-
Look into the metabolites of EtOH and carisoprodol respectively. You're playing with a lovely kinda fire. I'm in AA matter of fact I'm in a meeting at the moment. No alcohol in awhile. However, 2 lortab tens 3 350mg soma was my Crack! And at a young age too-

What is your question? I have no experience with gbh or gbl. Research time! Honestly I think you'll be fine if you stop drinking whatever means necessary.
<><
 
TrippyToes said:
Alot was said-
Look into the metabolites of EtOH and carisoprodol respectively. You're playing with a lovely kinda fire. I'm in AA matter of fact I'm in a meeting at the moment. No alcohol in awhile. However, 2 lortab tens 3 350mg soma was my Crack! And at a young age too-
Click to expand...
thanks for the response, I'm well aware of Soma/Carisporodol > Meprobamate, and that alcohol potentiates Meprobamate, that's part of the issue, I need to give the soma more of a kick and had been using Alcohol to do so
TrippyToes said:

What is your question? I have no experience with gbh or gbl. Research time! Honestly I think you'll be fine if you stop drinking whatever means necessary.
<><
Click to expand...
checking on the best HR method to take GBL along side soma as GBL/GHB have much steeper dose/response curve, GHB/GBL is a much more risky thing to take with Soma

AI cut and paste
[th]Feature [/th][th]Meprobamate + Alcohol[/th][th]Meprobamate + GHB[/th] [TR]
[td]Primary Receptors Involved[/td][td]\(\text{GABA}_{\text{A}}\) receptor complex[/td][td]\(\text{GABA}_{\text{A}}\), \(\text{GABA}_{\text{B}}\), and GHB receptors[/td]
[/TR]
[TR]
[td]Receptor Interaction Profile[/td][td]Overlapping (\(GABA_{A}\) Focus): Both drugs enhance \(\text{GABA}_{\text{A}}\) function, leading to additive-to-synergistic sedation.[/td][td]Cross-System Amplification: Meprobamate targets \(\text{GABA}_{\text{A}}\) while GHB targets \(\text{GABA}_{\text{B}}\), shutting down CNS signaling across distinct pathways simultaneously.[/td]
[/TR]
[TR]
[td]Dose-Response Window[/td][td]Linear / Predictable: Sedation scales relatively incrementally alongside blood alcohol levels.[/td][td]Non-Linear / Volatile: GHB possesses a notoriously steep dose-response curve. A minor dose increase can abruptly flip a user from conscious to comatose.[/td]
[/TR]
[TR]
[td]Metabolic Impact[/td][td]Alcohol acts as a competitive substrate, slowing meprobamate clearance and lengthening its effects.[/td][td]GHB does not rely heavily on the CYP450 system, meaning the synergy is almost purely driven by raw brain chemistry (pharmacodynamics).[/td]
[/TR]




AI cut and paste
  • Multi-Tiered GABA Inhibition: Alcohol and meprobamate both bind to the \(\text{GABA}_{\text{A}}\) receptor complex (though at separate binding pockets). GHB, however, bypasses this specific overlap to hit \(\text{GABA}_{\text{B}}\) receptors. Activating both the \(\text{GABA}_{\text{A}}\) and \(\text{GABA}_{\text{B}}\) systems simultaneously silences neuronal firing far more aggressively than overloading \(\text{GABA}_{\text{A}}\) alone.
  • The "Sudden Coma" Phenomenon: While an alcohol-meprobamate mix generally leads to progressive, visible slurring, ataxia, and heavy drowsiness, the GHB-meprobamate pairing causes a sudden, unpredictable loss of consciousness. Because of GHB’s steep dose-response curve, an individual can appear awake and functional one minute, and fall into an un-arousable sleep ("G-out") the next.
  • Exacerbated Aspiration Risks: GHB triggers acute nausea and vomiting much more readily than moderate doses of alcohol. Because the GHB-meprobamate combination causes sudden, profound unconsciousness alongside this emetic effect, the risk of lethal asphyxiation (choking on vomit) is vastly higher than it is with alcohol.

Summary
While mixing meprobamate with alcohol is dangerous and frequently linked to historical overdoses, combining meprobamate with GHB introduces a much higher degree of unpredictability. The cross-activation of distinct GABA systems creates a rapid-onset, steep sedative curve that leaves a dangerously thin margin between a desired effect and a fatal respiratory arrest.
To help provide more specific information, are you looking into this from a pharmacological/educational standpoint, or are you looking for guidance on overdose harm reduction?
 
People drank Alcohol to make G stronger. Or just because they drunk to.

BS it need s nothing, using it to replace Alcohol in function seems bit worst then combining Carisoprodol with Alcohol. But no experience with that class. But the combination of an opioid, benzodiazepine, and the skeletal muscle relaxant, carisoprodol, is commonly referred by the street name of ‘Holy Trinity’

Already seems risky. One or the other Benzo or Carisoprodol seems at least safer. I would never combine GHB or GBL with a downer. Have with a residue of a functional dose of Alprazolam. Taken the night before when WD ing from G.

Take as advice, tolerance is one thing but certain combos you propose seem riskier.
then taking or a good dose of one substance or a kinda proven relative trial combo.
 
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