Combining cannabis and enzyme inhibitors

[lavalamplynx]

THC is metabolized by CYP3A4, CYP2C9 and CYP2C19. if i inhibited all these enzymes would that increase the high? According to Wikipedia (totally accurate source of information btw) apigenin which is a flavone compound found in chamomile that strongly inhibits CYP2C9 and grapefruit juice strongly inhibits CYP3A4, would consuming chamomile tea and grapefruit juice before getting high increase the effects?

 

[Foreigner]

Inhibiting enzymes to get a stronger high mostly applies to first-pass metabolism, which means drugs that could through the liver via digestion (oral route). This would apply to THC edibles, but not as much to smoking/vaping.

If you inhale, you'll still get an effect that makes the high last a bit longer but it won't be as profound as if you took THC by ingestion.

You can experiment. Just make sure you're not taking any medications that can be affected by enzyme inhibition. It may cause their levels to spike in the blood which would affect your therapeutic protocol, such as by amplifying the drug. For example if you're taking a blood pressure med to lower BP, enzyme inhibition could make the drug lower your BP even more.

In my experience chamomile tea is weak and not worth it. Grapefruit juice works though.

 

[Allylbenzene]

THC is metabolized by CYP3A4, CYP2C9 and CYP2C19. if i inhibited all these enzymes would that increase the high?

This wiki has pretty good lists of enzyme inhibitors and inducers for the CYP family.

Cytochrome P450 - HerbPedia

herbpedia.wikidot.com

The body has enzymes that degrade endocannabinoids (eCB) too btw, including MAGL, 5LOX and COX2. Some receptors also release eCB's including 5-HT2A and TRPV1... and the eCB palmitoylethanolamide is OTC.