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Combination of Moclobemide and Tianeptine

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Advanc3d

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Not exactly sure if this section is the right place for it..

I know that SSRI's are obviously contradicted with SSRI's because reuptake inhibitors make the direction of serotonin flow one way in to the synapes where the MAO is meant to break it down. (which is where MAOI's cause a problem)

but where does the contradiction lie with SSRE(enhancers)?
Considering the direction of the flow is not inhibited, it's in fact enhanced, would this not mean it would just potentiate or make SSREs more effective?
 
Advanc3d said:
awesome reply mr moderator
Click to expand...

He is absolutely right.

Combining serotonergics with MAOIs is not a joke.

No, no, I insist... let me repeat that: mixing serotonergics with MAOIs is a very silly idea.

Why do people just love playing with MAOIs so much?

Advanc3d said:
I know that SSRI's are obviously contradicted with SSRI's because reuptake inhibitors make the direction of serotonin flow one way in to the synapes where the MAO is meant to break it down. (which is where MAOI's cause a problem)

but where does the contradiction lie with SSRE(enhancers)?
Considering the direction of the flow is not inhibited, it's in fact enhanced, would this not mean it would just potentiate or make SSREs more effective?
Click to expand...

It is because your mood does not translate simply into the direction of Serotonin's flow. It isn't a simple case if "increasing serotonin in the brain" or "putting it back in the cells" or "slowing down its metabolism".

Serotonin definitely plays some part in emotion, but it also plays part is just about every other thing in your body.

The danger of using gross methods like MAOIS + serotonergics is that you risk damage not only to your brain, but also your body, both because very little is known about how Tianeptine actually works, and also because you are neither a pharmacologist nor a researcher, but actually a guinea pig - and these are used for a reason: if one of them dies (painfully), they can always use another one for another experiment.
 
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Errr but the mechanism of SSRE is completely opposite to SSRI's

i still do not see how a MAOI, especially a reversible one would react with this particular substance. (mind you, i and over 40 of my friends do combine moclobemide with MDMA on a regular basis with no adverse effect) i did read a study that if serotonin concentration does get higher then the dose of moclobemide used, then the enzyme will become active again, hence serotonin syndrome is very hard to get with moclobemide.

refresh your knowledge on that... thank you.
PEOPLE HERE REALLY NEED TO LEARN THE DIFFERENCE BETWEEN DIFFERENT MAOIs!!!!

so many people even moderators think MAO-B inhibitors (has nothing to do with what im saying btw) somehow have the same adverse effects as MAO-A inhibitors.
Moclobemide DOES NOT have the same adverse effects, IF ANY, with other MAOI's


anyway back to what i was saying, SSRE would pretty much clean your synapses of serotonin. infact from what logic explains, having MAO inhibited wouldnt really do anything close to serotonin syndrome.


so i may have answered my own question then. but i still do want people to report if they have combined this, i did get a PM saying [someone did and there was no adverse effect and anyone saying otherwise is a complete idiot who hasnt looked in to it]
 
Moclobemide DOES NOT have the same adverse effects, IF ANY, with other MAOI's
Click to expand...


You should have tried telling me that as I lay drifting in & out of consciousness after consuming "contraindications" because I thought it was pretty harmless - actually i didn't think that, that's what i wanted to believe & so i did until ----------------------------------
 
Advanc3d said:
Errr but the mechanism of SSRE is completely opposite to SSRI's
Click to expand...
They do? Pray tell, how does Tianeptine do what it does? Hint: search Bilzor's posts on BL.

so many people even moderators think MAO-B inhibitors (has nothing to do with what im saying btw) somehow have the same adverse effects as MAO-A inhibitors.
Moclobemide DOES NOT have the same adverse effects, IF ANY, with other MAOI's
Click to expand...
See, this is very funny. Moclobemide is a MAO-A inhibitor, hun.
 
so at the end what happened ...
today i started using moclobemid but i also have tianeptin as well
so i also want to know whether there are experiences with mixing these 2
I would talk more about this if someone wants ...
But i wanna now ... what happened with this tread ....
 
I'm interested knowing thow they would combine too, obviously taking serotogenics with MAOI's is a bad idea, but tianeptine isnt just a SSRI, and we are in the advanced section here not basic drug discussion so i would like to see some real suggestions here instead of the standard "dont do it posts.
 
MeDieViL said:
I'm interested knowing thow they would combine too, obviously taking serotogenics with MAOI's is a bad idea, but tianeptine isnt just a SSRI, and we are in the advanced section here not basic drug discussion so i would like to see some real suggestions here instead of the standard "dont do it posts.
Click to expand...

Im curious too.

If tianeptine decreases extracellular serotonin creating a dopaminergic effect id assume it would behave the same way with an mao A, it would just take a higher dose to get a dopaminergic effect since the maoi increases extracellular serotonin even more. So i dont think it would be different just jack up the dose of stablon.
 
MeDieVil makes a very good point.

Whilst I do recommend speaking to a doctor if you plan on using this combination for therapeutic reasons, that's not because the doctor is would be well informed about the combination (if anything, I've found GP's to be useless when it comes to the theoretical aspects of pharmacology). Rather, it's that they know a good thing or two about harm reduction!

But this is the advanced forum, and this, at least IMO, is an excellent topic of discussion from a theoretical point of view. I'd love to hear from those with a deeper understanding of pharmacology of what we could expect from this combination, and whether it could indeed have therapeutic uses.
 
i agree with u all !
what i wanna know is DID SOMEBODY ACTUALLY DARED AND TRIED IT ?
moclobemid is excellent for memory and concentration and that is why i like it but i have noticed low libido from the very start even though i thought that one wont have that kind of effect as its not listed in side effects section.
sure its not that low like on citalopram venlaflaxin or sertralin but i want antidepressant and anxiolitic/sedative combination that does not effect libido.
i guess tianeptin will help me achieve this ! as that one doesnt effect libido
 
and maybe this is off topic but what are ur experiences with moclobemid.
untill i find the right tread for it .... thank u
 
Healthy living

Tianeptine is contraindicated with MAOIs according to its monograph. It is suspected that it indirectly elevates concentrations of DA/NE.
 
Yea well i am going to start taking Coaxil 2 times daily starting tomorrow.
leaving moclobemid.
i only hope i wont need f**ing benzodiazepines.
they are the best but i just cant take them anymore
i had enough of them !
 
what is this have to do with healthy living!? Sounds like some uninformed 17 year old wanting to take experimental drugs with other pharmies to make them stronger :D

if u want to trip out on the disassociative why not take more of it???
 
These are antidepressant/anxiolytic medications, which are considered disorders of mental health.
 
BUMP, any update on this?

Currently on Tianeptine but don't think it's helping so got some Aurorix but wont take any till find out more about the interaction of the two.. From what I gather so far it's NOT recommended to combine Aurorix with a tricyclic antidepressant which Tianeptine shares structural similarities to but has different pharmacological properties...

Any help is much appreciated.
 
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