What I'm seeing is this:
"This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis)." ( article is here )
The article also mentions harmful interactions with Benzodiazepines (like Xanax), some blood pressure and heart meds, and opiates and muscle relaxers - basically anything that will cause any sedation. I don't see any mention of stimulants, but that doesn't necessarily mean it's safe to use coke. My advice would be ask your doctor about it. You can just say you may do it once...or say you did once and ask if it would cause an issue. I've had a ton of experience with doctors (as I recently have had a lot of health problems) and some people would be surprised to know that they are very interested in harm reduction. When I was drinking heavily, I told my doctors and asked if it would interfere with medications. They aren't there to judge you and they aren't ignorant; they are well aware that people use substances that aren't prescribed and may not be legal.
I personally wouldn't kid around about seizures so be safe

...and welcome to Bluelight.