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Coke Questions --- Need Answers

I could think that the use of Benadryl-like OTC sleeping aids could possibly increase the cardiovascular effects of cocaine and the risk of a seizure. Diphenhydramine (the active ingredient in Benadryl) has noticeable anticholinergic component and thus can decrease the parasympathetic tone, especially if a high dose of Benadryl has been taken. This causes the increase of heart rate and possibly could act synergistically with cocaine. This is only my theoretical speculation...
For a sleeping aid after cocaine my recommendation would be benzodiazepines. They even can decrease the cardiovascular strain of cocaine and they increase the seizure threshold.
 
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