Opioids Coffee-Good or Bad w/ Dose?

[ty8705]

Hello All!

This is a topic that has mixed reviews / opinions; Coffee and your dose of opioids.

There are some that claim it potentiates the blood plasma content of opioids, while others say it directly impacts the opioid receptors in a negative way. I have been on my current dose for chronic pain since 2020, but up until recently I had my morning coffee with my first dose. Any suggestions would be appreciated. Chemists fire away as well!

Cheers!

 

[GooberDoober]

Hey, I am not up to date on the science of this so hopefully someone smarter can chime in, but I absolutely adore coffee with opioids. It definitely makes them a bit more pleasantly euphoric for me initially, and also seems to strengthen the nodding phase at times. That said, I actually already love coffee just as much as any other stimulant really, so it might just be that the coffee euphoria is blending with the opioid euphoria instead of actually boosting it. The nod could also be boosted by mixing with my coffee crash a few hours later. So im not sure how it works, but there is a long medical history for combining opioids and stimulants, and it feels nice regardless of whats really going on.

 

[paranoid android]

I like having my coffee in the morning with a shot of morphine. Wakes me right the fuck up

 

[KurtAurelius]

I believe there is robust evidence that caffeine potentiates opioid analgesia, plus stacking dopamine on top is really nice

as I’ve gotten older I much prefer the combo of caffeine and opioids, it makes you productive and uplifted, and I agree that the euphoria is stronger.

I don’t really seek the nod anymore, I haven’t really thought of this but with multiple months of opioids, and then coming back with quite big doses of codeine (240mg or so ) or DHC I get a bit sedated but I don’t ever nod like I used to as a kid.

But the nod was more alluring as someone perpetually suicidal. Nowadays I’d rather keep busy as it feels better.

I’m getting Mitragyne extract coming (two doses equivalent to 4 grams of powder)

I’m curious to see how that will feel compared to Codeine/DHC with Caffeine.

I’ve also Opioids (safe ones without weird activity) combined with methylphenidate, it does kill some warmth but the mood lift is crazy and the enjoyment. Damn when I used to have the 1-2x 120mg ER DHC with 54-72mg Concerta, that day would be flying by.

 

[ty8705]

Thanks for the reply! I put this thread out there because I came across one awhile back that swore up and down caffeine itself acts like narcan. This person went into the deep chemical breakdown of it. It could be based on each persons body too. I know I’m one of the rarer ones who are a legacy responder.
~3–5% of chronic-pain patients who have a specific cytochrome P450 profile (especially CYP2D6 extensive or ultra-rapid metabolizers paired with certain OPRM1 receptor variants). My liver converts the oxycodone into oxymorphone very efficiently, I hit steady-state plasma levels fast, and my mu-opioid receptors never really down-regulate the way they do in most people. In other words my tolerance has NEVER changed in five years on my dose. I keep the same effect / pain relief since day one!

 

[GooberDoober]

Thanks for the reply! I put this thread out there because I came across one awhile back that swore up and down caffeine itself acts like narcan. This person went into the deep chemical breakdown of it. It could be based on each persons body too. I know I’m one of the rarer ones who are a legacy responder.
~3–5% of chronic-pain patients who have a specific cytochrome P450 profile (especially CYP2D6 extensive or ultra-rapid metabolizers paired with certain OPRM1 receptor variants). My liver converts the oxycodone into oxymorphone very efficiently, I hit steady-state plasma levels fast, and my mu-opioid receptors never really down-regulate the way they do in most people. In other words my tolerance has NEVER changed in five years on my dose. I keep the same effect / pain relief since day one!

I have never been more jealous.

 

[ty8705]

I have never been more jealous.

It is wild. Probably why my provider has no problem working with me if I need to fill a day early for a schedule change. I’ve been on OxyContin 20mg 2x daily and Oxycodone 10mg x3 for breakthrough daily. I probably could up it to 4 IR daily, but I think it’s best not to stir the pot.

 

[vacuole]

Good

 

[Keif' Richards]

Yea, I mean, I take caffeine every day.

I feel that Opioids, being a sedative, are perfect for combining with a little bit of caffeine. I´ve only ever heard of stimulants in general creating etither an objective or subjective increase in the effects of the Opioids. This goes with everything from Caffeine to Amphetamine.

There are often interactions that are dependent upon how acidic your stoamch is. As Coffee is acidic, I would just reccomend taking it after your Opioid. Not all Opioids are impacted by the Ph of the stomach, but Methadone for instance, is.