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  • BDD Moderators: Keif’ Richards

codeine

B

brasil

Bluelighter
Joined
Aug 25, 2008
Messages
305
Location
Rio de Janeiro Brazil
am i crazy? or 600mgs of pure codeine 3 times a day ins't that much?
My tolerance is in that level. For me, to stay all day high, i take about 1.200mgs to1.800mgs of pure codeine plus 13 mgs of clonazepam/day. Is it awfully dangerous? please help me here, cause i'm feeling al right!But don't want to screew it up
 
personaly codein dont do f*all to me but if you aint been on the h before then that amount when you aint got nout is gonna hurt, also love clonazepam but you gonna be world of pain if you aint got a script for when you run out you f.u.b.a.r
 
wow, im doing between 120 and 180 twice a day, and I was getting worried I was overdoing it, guess not !
 
codeine has a ceiling effect of 400 mg meaning you cannot get anymore effect out of it by taking more than that, in effect your wasting the extra amount
 
Am i correct in thinking the ceiling effect is because there is only so much of some enzyme converting it to morphine available at one time?
 
Organ damage is being done regardless. Opiates aren't harmless.
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Cite? You are very wrong on this. I've been using codeine for years without damage to my body, and I have had testing done which at the least would have revealed liver damage.

codeine has a ceiling effect of 400 mg meaning you cannot get anymore effect out of it by taking more than that, in effect your wasting the extra amount
Click to expand...

Not true for everyone. Just as 10% of the Caucasian population are missing the CYP2D6 enzyme necessary to convert codeine into morphine, some are able to metabolize it extensively into morphine. I have taken my tolerance to codeine up to 2 grams before.

It was most definitely not a placebo effect either - that tolerance carried over to other opioids as well.
 
The ceiling is different for everyone, 400mg is just average.

I do a lot of codeine and poppy seeds daily, but my only worry is tolerance, particularly with CYP2D6... Is there a cumulative effect of the CYP2D6 inhibition?

I assume doing it twice daily wouldn't yield the same high as doing it once daily, not justg because of the immediate opiate tolerance, but because a lot of CYP2D6 is still 'inhibited', right? So what I'm asking, if the former sentence is true, is does the inhibition slowly rise over time? Like if I do it daily and say 25% was inhibited everytime, could eventually 40% be inhibited ?(if I continued doing it once daily).
 
^ No. The inhibition of your liver enzymes doesn't work in the same way as tolerance does. They are just inhibited whilst they are 'tied up' with the drug molecule that is inhibiting them (in this case, codeine itself).

Off topic: I highly recommend Jeff Wayne's Musical Version of the War of the Worlds to listen to whilst nodding. It is fucking awesome.
 
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