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  • BDD Moderators: Keif’ Richards | negrogesic

Codeine itch, Zyrtec the better than benadryl?

pirat3

Bluelighter
Joined
Nov 6, 2009
Messages
47
Location
the road to discovery
Codeine has started to make me REALLY itchy every time I use it now, but I hate to use Benadryl when I'm on it because codeine relys on the CYP2D6 enzyme to be metabolised into morphine (if I'm not mistaken.) which is the same enzyme that metabolises Benadryl. So in theory, taking Benadryl with your codeine would reduce its potency, correct?

I did a little bit of research and found out that Zyrtec is metabolized by the CYP3A43 enzyme, so am I correct in believing that this would be a better antihistamine to use?
 
As long as you take the Diphen after you start feeling the Codeine then it won't inhibit the conversion to Morphine. Zyrtec (Cetirizine) will be fine to take aswell but won't have any added sedation, which can be good or bad depending on yer POV.
 
I keep seeing posts about cyp2d6. Please understand that if you have a good liver then you won't run out. Alot of the crap on the net from erowid etc is theory or tested on other animals. We are humans and very different to a monkey. Our creator made us to take drugs or.....we evolved taking drugs, either way we can handle most of what narcs tell us we can't. And i don't mean the anti drug adds etc. I mean the medical journals and docs stateing its ceiling effect is 400mg or the "LD50" is such and such. BULL> I use 1g a day in one dose. I've dosed 8 times in a day 24hrs of 200mg per dose. And felt every one. CWE must be done when APAP etc is involved. Oh, and i'm 50kg so the calculation per weight aint true either. 10 Years of dosing and i'm still healthy...ish. Love H but can't afford it, and can't control myself with it, so deines is my means. Oh, 4 days off i lower to 600ml to lower receptors then creep up. Peace and goodluck.
 
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