Codeine and CWE Megathread - The long awaited!

[opi8]

You IV-d Codeine?? Thats a very silly thing to do, I suppose u learnt from ur mistakes. Im not surprised about the adverse reaction and histamine release etc etc. IM isnt safer either. Not sure why people assume it is safer. Good thing that ur still alive which is the main thing.

IM codeine is safe, and has been used for a long time in medical settings. Unless of course you meant IM'ing pills that contain codeine, then that's not safe as it's likely to give you an abcess.

Of course, as everyone here knows, IVing medical grade codeine can be deadly, don't do it.

 

[psytaco]

Hurt my back at the gym the other day. Now I actually need codeine for pain relief, and due to using it recreationally it is not sufficient. Grrrr. Added to this the doctor only prescribed me 24 panadeine extra (yeah extras - not fortes), and told me she'd give me repeats but didn't.

Anyway, I'm going to ask the pharmacist near me not to be an arse and let me buy this regularly for the next week or so.

Also, in terms of DXM potentiating codeine, how much DXM is necessary to potentiate it and what is the brand that only contains DXM?

 

[footscrazy]

Robotussin dx (dry cough) is the right one. I use between 30-60mg of dxm (10-20mls) 30 or so minutes before taking the codeine to potentiate. Having another dose of about half the initial dose around 20mins after you've drank the codeine also seems to help, if you're going to do that though, stick to a lower initial dose, otherwise the dx can start giving the codeine high a weird edge.

Hope your back gets better soon

 

[Anon54]

^^lol only problem is if i would buy dxm to potentiate id end up drinking the whole bottle & go into robotripping bliss.
havnt touched dxm for yrs but it would be tempting if i bought the bottle. i mean its way more euphoric than codeine.

i only take codeine these days though. dxm is some really powerful stuff. i have no idea why it's legal. they might as well legalize PCP

its also like buying a case of beer with the intention of only drinking 2 beers to potentiate ya valium. like that's gunna happen.

.....half a case later fall on the floor

 

[88brenno]

Sorry to hear that psytaco, I didnt realise panadeine extra was prescription only in Melbz that sucks, Is 10mg OTC cause you could go chemist hopping I dont think Codeine is as restricted as Pseudoephedrine or you could try explaining to the doc that the panadeine extra didnt touch the pain?

 

[Anon54]

just get a 40 pack of chemists own pain tablets. i have some in the freezer now
just use them they're cheap, they dissolve almost instantly too so u dont have to crush up the tablets
im trying to quit codeine. i feel sick right now & have to wait another 10 mins or so to drink it.....

edit: just had my codeine. i actually LIKE the taste of it these days. i mix it in with some cold water & drink it all down in a sip. Most ppl dont like the taste of beer when the first try it. its like codeine u get acquired its taste!

 

[Mr Blonde]

Sorry to hear that psytaco, I didnt realise panadeine extra was prescription only in Melbz that sucks, Is 10mg OTC cause you could go chemist hopping I dont think Codeine is as restricted as Pseudoephedrine or you could try explaining to the doc that the panadeine extra didnt touch the pain?

Panadeine Extra isn't prescription only there, the doctor just wrote a script for that. They can write scripts for any drug, whether it's OTC or prescription only.

I think his post was getting at the idea that he will visit the same pharmacy and talk to the pharmacist about his pain medication requirements, as he didn't get repeats for the Panadeine Extra and as we all know some pharmacists will get in your face if they think you are buying it too often.

 

[88brenno]

I dont think the same pharmacy will sell him more boxes at a time anyway because of the high paracetamol content, its not like they know hes going to CWE it hence they think it is putting him at risk of paracetamol overdose.

 

[psytaco]

Panadeine Extra isn't prescription only there, the doctor just wrote a script for that. They can write scripts for any drug, whether it's OTC or prescription only.

I think his post was getting at the idea that he will visit the same pharmacy and talk to the pharmacist about his pain medication requirements, as he didn't get repeats for the Panadeine Extra and as we all know some pharmacists will get in your face if they think you are buying it too often.

yep you got it. Asked the pharmacy if I could go back there and get more tablets, and he said no, max of one codeine containing product a month. fucking bullshit! So now, with a sore back I have to walk around to different pharmacies and remember which ones I hit up recently.

Anyway, not doing CWEs for this. I'm sticking to the dosage and not having more than 8 tablets a day. BTW, say if I had two tablets of codeine+APAP and 2 tablets of codeine+ibuprofen, that doesn't put too much strain on your liver or other organs does it?

 

[Mr Blonde]

^ It's fine to mix the two together, as long as you can tolerate ibuprofen fine. Just watch out for longer term use of it having problems if you aren't CWE'ing. Hope it helps with your pain.

 

[Sustanon]

Hurt my back at the gym the other day. Now I actually need codeine for pain relief, and due to using it recreationally it is not sufficient. Grrrr. Added to this the doctor only prescribed me 24 panadeine extra (yeah extras - not fortes), and told me she'd give me repeats but didn't.

Anyway, I'm going to ask the pharmacist near me not to be an arse and let me buy this regularly for the next week or so.

Also, in terms of DXM potentiating codeine, how much DXM is necessary to potentiate it and what is the brand that only contains DXM?

Take the DXM right before you dose the codeine otherwise it will over ride it and def will give it a weird edge.

 

[88brenno]

One box a month how crap is that if your taking 8 tablets a day thats only 3 days of pain relief! I suffer sore back, have you got some Deep Heat? I use that and these patches that are basically deep heat but a cheap asian brand.

 

[pinkanga]

The poppy seed tea (1kg) smashed me last night. I don't know why, usually it does next to nothing. But I was up all morning vomiting from the shit, so I don't think I'll be touching this stuff any time soon.

Yeah sometimes the next day I feel pretty sick. Really dehydrated too...

Dont think its the best thing for you. I was having 960g when I occasionally did it.

 

[Anon54]

quoted from wikipedia's codeine page

Codeine is metabolized to C6G by uridine diphosphate glucuronosyl transferase UGT2B7, and, since only about 5% of codeine is metabolized by cytochrome P450 CYP2D6, the current evidence is that codeine-6-glucuronide (C6G) is the primary active compound.[20] Claims about the supposed "ceiling effect" of codeine doses seemed to rest on the assumption that high doses of codeine saturated CYP2D6, which prevented further conversion of codeine to morphine, which is simply incorrect since we now know that codeine-6-glucuronide (C6G) is the main metabolite responsible for codeine's analgesia.[9] There is also no evidence that CYP2D6 inhibition is useful in treating codeine dependence,[21] though the metabolism of codeine to morphine (and hence further metabolism to glucuronide morphine conjugates) does have an effect on the abuse potential of codeine.[22] However, CYP2D6 has been implicated in the toxicity and death of neonates when codeine is administered to lactating mothers, particularly those with increased 2D6 activity ("ultra-rapid" metabolisers)

I dont understand this.. so 10% doesnt convert to morphine. it must add to the abuse potential?
trying 800mg btw atm

 

[Mr Blonde]

^ The article is trying to make the argument that the morphine conversion is not the important part for analgesia, recreational effects and addiction just that it 'does have an effect'. They are trying to make the argument that C6G is the major product for these effects, which is a view point not that well supported by the currently available evidence.

The article didn't used to be worded like that, I saw it changed a couple of months ago or something to this. Take a look at source 21, it's a study where they attempted to use fluoxetine (Prozac) to inhibit CYP2D6 and thus reduce the use of codeine by those addicted to it. Whoever wrote this part of the article is trying to use that as evidence that C6G is the important metabolite for the effects of codeine, but it is not a good indicator as you are not achieving total inhibition of the enzyme. I used codeine for a while alongside fluoxetine a few years back, and the effects were significantly reduced. The same thing happens if I take promethazine before codeine, as promethazine is an inhibitor of CYP2D6 as well. It can make three boxes feel like two or less.

This is just my personal experience and isn't a scientific study, but from the results I see in myself it would appear as though CYP2D6 mediated metabolism of codeine into morphine is the major contributor to effects, with C6G and other metabolites having probably minor effects that have not been shown in humans yet.

 

[ezz]

I do CWE's quite reguarly from panadeine extra and was wondering if anyone knows how to make the affects last a bit longer?? Each time I do it it feels really good but for only about fifteen to twenty minutes. Is there a way I can increase the potency or make the euphoria last longer??
thanks

 

[Sonny Jim]

yes, you can convert the codeine to morphine then to heroin in you kitchen lab (jokes)

or you can read back through the thread and find out about all the stuff people mix with CWE to get the most out of them. grapefruit juice, DXM, benzos, drowsy OTC antihistamines.

 

[88brenno]

Alot of people swear by DXM being a good potentiator but don't do too much, 30-60mg MAX one last thing make sure the bottle doesn't contain Guaifenesin that will make you throw up.

 

[Sustanon]

I do CWE's quite reguarly from panadeine extra and was wondering if anyone knows how to make the affects last a bit longer?? Each time I do it it feels really good but for only about fifteen to twenty minutes. Is there a way I can increase the potency or make the euphoria last longer??
thanks

The effects of codeine/morphine only lasts about an hour or 2. Im usually sober within 60minutes. DXM is a very good potentiator although at some point you will become tolerant to it and it wont do much. Increasing teh dose of the DXM isnt an option as it will completely over ride the effects of the codeine and give it a weird edge feeling. Buds and xanax go very very well with it making it last a lot longer although use with caution as its dangerous to mix opiates with benzos. 360mg-600mg + buds and half a bar would be on the safer side depending on benzo tolerance and of course tolerance to the CWE. I plya around with the cwe dosages. 360mg for my usual doses and if I feel like getting more fuked up id use 600-800mg.

 

[Dr Phibes]

That is surprising. I find my usual dose of 360, or up to 540 if I have been taking it more than a few days in a row, gives me a really good buzz for between 4 and six hours. Benzos improve it but don't extend it. Thought this was normal.