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Codeine and CWE Megathread - The long awaited!

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Hey Stato, if I was you I would not keep that evapped CWE around for too long, I have heard of CWE's going off in solution after a day or two and if that ball has moisture in it then it could also go off pretty quick.

Indeed, I rolled that ball up and put it into 4 size 0 pills... could have packed it more but yeah.

Took the 4, and 50mg promethazine tonight while out hosting an event.. I didn't really notice too many effects because I spaced it out (2 then another 2 about 1hour later). It's definitely got me pretty dopey though, I think If I'd taken the lot in one go I would have had some nice itchies and body warmth/euphoria going.

Now that I am home ( keeping in mind I've had 2 drinks in 4 hours too) I'm pretty bombed so to speak.


It's a lot of hassle, and I only did it as an experiment... It obviously works I just have a bit of a tolerance to opiates as I've recently been on 4mg bupe during the last week.

Next time I'll definitely try for a bigger batch, And maybe dry at 40c in the fan forced oven, instead of 70.
 
80C is the decomposition temp for codeine; I'd put it in at around 70C and leave the door open.

Or alternately use a separate method for getting out the codeine that I won't disclose on here.

Gotta be careful as heat can and will decrease the potency of the codeine. Im not exactly sure hwo much but from what i can recall it was quite low thats the main reason why I didnt go ahead with that tek. Tbh id rather do a A/B extraction on it but some chems are hard/suss to get.

Just curious Stato what method did u use to evaporate? and also other details like how long it took u etc etc
 
Interesting to see the results of evaporating codeine solution. I thought about doing that myself a few times but never got around to it.

Just as an aside.... am I correct in thinking that the law of diminishing returns applies to codeine taken in the one day? ie. Say I have 800mg codeine at my disposal... usually I just take the entire amount at once thinking Ill get the most back for my buck... but occasionally I like to watch a movie or something then play some video games and would like to re-up with some more codeine. Is there any point at all in splitting it up into say 500mg earlier in the day then 300 later in the day?

I assume taking the 300mg a few hours after the 500mg will have little to no effect right? I obviously have a pretty high tolerance.
 
Yeah redosing it wont do much. Tolerance to codeine rises so quick. Id say potentiating it would be a better idea or just simply take it at once like u do.
 
has anyone noticed that mixing heroin and codeine results in a better sleep?

the other night I downed about 60ml rikodeine X 19mg of Dihydrocodeine along with about 10-20mg of IV heroin and found that I had a much better sleep then I normally do....
 
I assume taking the 300mg a few hours after the 500mg will have little to no effect right? I obviously have a pretty high tolerance.

I've been told or have read that redosing is literally useless...but I can remember it working ok for me in the ancient past.

I would have been on lower doses though, so sustanon probably knows whats what.
 
has anyone noticed that mixing heroin and codeine results in a better sleep?

the other night I downed about 60ml rikodeine X 19mg of Dihydrocodeine along with about 10-20mg of IV heroin and found that I had a much better sleep then I normally do....

That's what you get with the big jobs 8)
 
^ Codeine shouldn't be injected even if pure, due to it's histamine effects.

I will leave your post as is but don't take the chemistry talk past an extraction. Definitely no synthesis discussion or anything like that.
 
Sorry Mr Blonde. got a bit into the chemistry side of things but tried to make it vague, have removed the post. Just trying to provide some ideas to reduce the unwanted material ie 1g brufen - 400mg codeine, this CWE needs some more work. I'll just say use a evap. basin low heat/dry heat and maybe research some purification methods to remove as much unwanted product as possible. CWE is a basic hot solvent extract ie hot water= paracetamol soluable, cold almost insoluable, paracetamol becomes a solid (recrystallisation) in the solvent (H20) and codeine remains dissolved in the solvent. Filter solvent etc. 1 gram of brufen should not be that bad I guess but may need some food to prevent it interacting with the stomach reducing the alkaline layer protecting the stomach from HCL and causing ulcers. Codeine should not be IV/IM/SC that is beyond a doubt. I have seen people who have had some very rough "smack" that was basicly codeine + paractemol/brufen contaminate, it caused infection raised LFT's and the ALT and AST were through the roof due to hepatic toxicity. Also they had extensive edema and erythema at injection site.
 
Ok, Im not going to say the cold water extraction is outdated but just quietly it is....

Ok, where do I start... Iv worked with a lot of apap/codeine extractions and apap is a fkn shit of a thing to seperate properly even in the cold water...

2ndly, if u take 10gram of apap and u absorb it into a litre of scolding hot water and then u put it in the fridge... just watch how long it takes for the apap to crystalise.... my point is this.... if u extracting 24x500mg/10mg apap/codeine pills then u want to leave that shit in the fridge for at least a day once uve filtered the pill filler...

ok, next; ibuprofen/codeine pill are much easier... 800ml of scolding hot water to 24 pills and then filter through denim or good filter material (tightly woven) and you have a crystal clear solution of codeine and only trace amount of ibuprofen... I can do this method in 30-50mins and have it drunk by the hour, always tops results and I love my codeine.

EDIT: Codeine shouldbnt be injected but it can to no effect... addicts from a time past used to inject opium resins boiled into water and altho its bad for ur viens, like injecting mayple syrup; it will only kill u from an overdose on morphine or from long term use and the load it would put on ur kidneys.
 
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but may need some food to prevent it interacting with the stomach reducing the alkaline layer protecting the stomach from HCL and causing ulcers.

It's actually a myth that ibuprofen or other NSAIDS cause stomach ulcers or stomach upset via direct irritation. The ulcers are caused as part of the general mechanism of action of these drugs; once they are absorbed they inhibit prostaglandin synthesis, hormones which contribute to inflammation but also play a role in the creation and maintenance of the gastro-intestinal mucosa.
 
It's actually a myth that ibuprofen or other NSAIDS cause stomach ulcers or stomach upset via direct irritation.

Actually that's good to know because I always take it on an empty stomach. But why do most pharmacists tell you to take it with food?

Also I'm thinking of taking a tolerance break, how long would I need to abstain to get the best possible effects? I have gone for 2 weeks without it but the effects at my initial doses were nowhere near as pronounced as the first few times I used it.
 
2ndly, if u take 10gram of apap and u absorb it into a litre of scolding hot water and then u put it in the fridge... just watch how long it takes for the apap to crystalise.... my point is this.... if u extracting 24x500mg/10mg apap/codeine pills then u want to leave that shit in the fridge for at least a day once uve filtered the pill filler...

Whats the point of this?


No one uses scolding hot water. I use water from purifier that is between 7-11 degrees. The pills usually flour out and form a sludge in a matter of minutes that easily mixed/stirred. I then throw it in the fridge or the freezer for a bit, stir it again, back in the freezer for 5-10mins (its usually pretty cold still so gotta be careful about freezing) or Ill just throw it in the fridge for half an hour and let the shit settle at the bottom then squeeze through a shirt then filter through a coffee filter.

Almost always get crystal clear solution unless using generic brand 10/500 pills which seem to have some sort of colouring in them.... or are just messy for some reason.

But who would use scolding hot water like you say? That apparently isnt good for the codeine anyway.
 
Actually that's good to know because I always take it on an empty stomach. But why do most pharmacists tell you to take it with food?

Also I'm thinking of taking a tolerance break, how long would I need to abstain to get the best possible effects? I have gone for 2 weeks without it but the effects at my initial doses were nowhere near as pronounced as the first few times I used it.

Pharmacists will tell you that because it is still widely believed that it will do something, and even among the ones who know better it's a force of habit. There have been a couple of articles in the Australian pharmacy periodicals though debunking this.

When I take a break it's usually for a couple of weeks or so, I find my tolerance drops only by about 200mg or so though.
 
I use warm water maybe 50 degrees or so (use thermometer) Then cool material in fridge. Then initiate 1st extract and keep in fridge overnight. 2nd extract is then performed and also kept in fridge. I dont let the CWE get above 10 degrees while transfering from 1st filtration to 2nd. You can further remove brufen or paracetamol by reducing the volume of solvent (distilled H20) ie 1st 150/200ml then 2nd 100/50ml the more pills the more solvent needed. The second filtration is then performed while temp 4 degree c (in fridge). This process may take 30+ hrs and can use 48+ 15mg tablets. The material present in the solvent stands for a few more hours at 4 degree c. An alternative recrystalisation method can then be performed. Brufen as Mr Blonde. has stated causes inhibition of the cyclooxygenase pathways cox 1 and cox 2. Cox 1 inhibition disrupts the stomachs epithelial cell production of bicarbonate rich mucosa that lines the stomach and prevents HCL, created by the parietal cells, damaging the stomach membrane. Dr's always over simplify the mechanism of action of medications ie heparin will "thin your blood" brufen will irritate your stomach etc. The Cox 1 is responsible for haemodynamic stability and inhibition of cyclooxygenase 1 creates issues with respiration (esp. asthmatics) and other functions. Cox 2 inhibition targets macrophages and other cells involved in inflammatory reponse to injury. Paracetamol targets cox 2 and cox 3. I don't perform CWE's very often anymore. I will try a brufen CWE at some point however I am very sensitive to NSAIDS.
 
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I find even a couple days can help with tolerance (if youre a daily user... oh joy ;))
 
Ok. did another CWE evaporation using 60 generic ibuprofen (200mg) and 12.8mg codeine per tablet.

This CWE evap'd in a much shorter time as I used a larger dish and much less water. It evaporated to a powdery substance which I then pressed into another tablet and swallowed. Maybe 1/5 of the amount present. I also took 2 size 0 capsules full at this time aswell. (20 minutes ago). On top of that I took 50mg promethazine. And I'm currently awaiting effects.


Will post a photo of the evap which looks much better when i can get around to it.


EDIT: took a couple more capsules (4), maybe half the powder down the hatch (hopefully about 300~mg codeine total) - I'm feeling the effects now, body warmth, etc.
 
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Paracetamol targets cox 2 and cox 3.

It is also metabolized to AM404, which prevents break down of endocannabinoids in the brain particularly anandamide. The same substance is also a weak agonist at certain cannabinoid receptors.
 
It is also metabolized to AM404, which prevents break down of endocannabinoids in the brain particularly anandamide. The same substance is also a weak agonist at certain cannabinoid receptors.
A very interesting and little known fact. I love the look on old peoples faces when you tell them their "panamax" produces this metabolite, the looks on their faces LOL!
 
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