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  • EADD Moderators: Pissed_and_messed | Shinji Ikari

Cocodamol - The drug of the credit crunch? plus other codeine/dihydrocodeine queries

Funny you should mention that Ismene, I had the same thing happen last Monday I think it was, the chemist guy said the exact same thing as with you, except he then went about lecturing me about how the tablets contained paracetamol and not to take above the stated dose. And I was like "yeh, well CWE ye" - in my mind. But he still sold them me, i'm laying low for a while and using a different chemist =D.
 
LOL! Yeah I've been thinking about going round every chemist in the district on a rota basis but I can't decide whether codeine is that good enough a high to bother :D
 
Visited a local chemist today while round a friends so he could pick up something for his dad and noticed the morphine and opium syrups were just behind the counter on clear display, i was like =o good stuff! now just gotta buy them rarely enough for them not to suspect :D
 
READ THIS!!! Clearing a Few Things Up!!!

I just wanna clear some things up...

Ibuprofen is like Aspirin as it's an NSAID (Non-Steroidal Anti-Inflammatory Drug) but doesn't thin the blood. If you're allergic to one, you're allergic to the other!!! They shouldn't ever be taken together! You can take either one with paracetamol.

Injecting codeine and dihydrocodeine is very dangerous as it causes a large amount of histamine to be released which can cause pulmary oedema/edema(American English).

If you are using codeine don't go any higher then 400mg or 450mg, as this is the ceiling dose after which your liver can't process anymore into morphine (Dihydromorphine in the case of Dihydrocodeine) and is pissed out basically unchanged. So taking anymore then 400mg or 450mg is a waste!!!!

The Morphine in Koalin and Morphine can be skimmed off if you leave it to settle of a couple of hours. You can see each different coloured layer when you leave it to stand.

Adding 50mg - 100mg of diphenyhydramine/Nytol that's 2-4x normal Nytol or 1-2x double strength Nytol. Ask if the pharmacy do their own generic version, as it'll be cheaper!!!

Diphenyhydramine/Nytol in the blue packet is a pharmacy only med', make sure you get this and not the shitty herbal Nytol which is sold everywhere in a green packet. Nytol is a deleriant so don't take more then 100mg!!!


Someone in an earlier post said to 'bosh' co-codamol if you can't be arsed CWE'ing. Now I don't know if they mean cut/splitting them, which can only be done with Nurofen Plus. or if they meant injecting them. I've already covered injecting it, but if they did mean cutting/splitting them then NO NOT DO THIS WITH CO-CODAMOL!!! As I've already said it can only be done with Nurofen Plus. To get high on Nurofen Plus cut the tablets length ways and take the N+ side, the other side is the ibuprofen. The tab's no longer seem to split evenly.

Just thought I should clear them up for health and safety reasons! ;)
 
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Injecting codeine and dihydrocodeine is very dangerous as it causes a large amount of histamine to be released which can cause pulmary oedema/edema(American English).
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Agreed, but I don't think anybody was saying anyting different.

If you are using codeine don't go any higher then 400mg or 450mg, as this is the ceiling dose after which your liver can't process anymore into morphine (Dihydromorphine in the case of Dihydrocodeine) and is pissed out basically unchanged. So taking anymore then 400mg or 450mg is a waste!!!!
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Never been convinced by this cos the difference between 500mg and 1000mg is very noticable. If it stopped working at a point before that then why is it so diffenent? 1000mg feels, perhaps unsurprisingly, twice as strong as 500mg.

Both practices are damnably itchy though :|
 
You might be one of those with damn fiiiiiiine CYP 2D6 production, Sham ;)
I've never tried going above 400mg myself. It would involve too much grinding of tablets and filtering et se tuh rahh, et se tuh rahh...
 
Shambles said:
Agreed, but I don't think anybody was saying anyting different.



Never been convinced by this cos the difference between 500mg and 1000mg is very noticable. If it stopped working at a point before that then why is it so diffenent? 1000mg feels, perhaps unsurprisingly, twice as strong as 500mg.

Both practices are damnably itchy though :|
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The LD50 for Codeine is meant to be around 800mg or 850mg, but people start to OD at 600mg apparently! So if people are taking these kind of doses watch what you're doing and make sure you have someone around incase you turn blue!

Maybe tolerance is an issue here? How often do you use? If you take a break from opiates do you jump straight back in at high doses of codeine? Roughly how much?

Shambles DF's are dihydrocodeine. Do you have 120mg Dihydrocodeine pills? Some people say there's a ceiling limit with dihydro' and some say there isn't.
From what I know Dihydro's basically the same as Codeine and I imagine it has a ceiling dose too! But do you own research! ;)
 
i'd say my ceiling dose for codeine is closer to 600mg than 450mg, don't get anything worthwhile out of less than 300mg though so maybe just high natural tolerance?
 
I think there may well be something to the enzyme business - if some people have deficiencies then some would presumably have excesses? Don't know.

Gaz: The codeine LD50 looks way off too me - I've been scripted more than that daily before :D

Tolerance would have been an issue at the time, for sure. I don't use codeine that often now, but would be dosing in a similar range to Evad with no tolerance. Others get full effects from 120mg or so so definitely a wide variation.

DF's are sadly a thing of the past, and I only used them to taper or to avoid withdrawals so have no idea about ceiling doses. Never noticed one, but I was a long-term heroin addict at the time so didn't really notice them at all unless I was clucking :|
 
8% of white people can't metabolise codeine>morphine, that's the thing i have learnt today
 
the article i just read said it meant they got little>no effect from it because of this :\ damn internet
 
Ah! May be an entirely different thing then - was thinking of the enzyme deficiency that Monsta mentioned up there. Little or no effect would be truly shit. Unless it meant you had to prescribed morphine cos your body couldn't convert codeine...
 
think it might be a different thing

a more edumacated man than i said:
As a pain medication, its effect occurs because of partial (approximately 10% ) metabolism to morphine in the liver. The active enzyme in the liver responsible for conversion to morphine is the P450 2D6 enzyme. The 2D6 enzyme is also active in the metabolism of many medications, including paroxetine, sertraline, and others. Approximately 8% of the white population lacks 2D6 enzyme metabolic activity. It would be expected that those with limited 2D6 activity would get littleor noanalgesic effect from codeine. Of interest, codeine is effective on the cough reflex regardless of the conversion to morphine.
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Interesting. New one on me too - different enzyme entirely. More of a minefield than I thought this codeine business. See that it stops some SSRIs from working too. Morphine for pain relief and no SSRIs... I almost wish I lacked the aforementioned enzyme :D
 
Fancy another bottle of cough syrup. I wish I had some good disguises
 
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