Cocaine + benzos + pregabalin + ketamine

[ativ;anhero]

How dangerous is this combo? I'm dependent on benzos so I need to take them but the comedown from coke is so horrible K and pregbalin seem to help if not erase it if used before and/or during. Just worried because I've heard that both coke and pregabalin are some kind of channel blockers or something and that could potentially be dangerous, but have also read glowing reports of people mixing the two.

 

[Pissed_and_messed]

coke is sodium channel blocker if I have not mistaken, whereas pregabalin is voltage-dependent calcium channel blocker.

There is much going on, all those, excluding benzos, have more or less real potential to cause high blood pressure and pulse. I don't immediately see any catastrophic risk but I am really inexperienced with coke, particularly with whatever it may contain.

 

[ativ;anhero]

coke is sodium channel blocker if I have not mistaken, whereas pregabalin is voltage-dependent calcium channel blocker.

There is much going on, all those, excluding benzos, have more or less real potential to cause high blood pressure and pulse. I don't immediately see any catastrophic risk but I am really inexperienced with coke, particularly with whatever it may contain.

Thank you for your insight! So coke and pregabalin working on different channels makes it not an issue? And also could I use the benzos to lower heart rate and blood pressure?

 

[Pissed_and_messed]

I recall that sodium channel activity is not great for heart over time, but I am not sure if I've got it right. Point was that pregabalin does not have that kind of serious feature, but there is much going on with that one also, like how it can have paradoxically pro-glutamate effect, so it could still pose some kind of risk in complex combinations of drugs that is not really ever been studied.

I would do that kind of combo myself, but it does not mean it is great for you, obviously I'd call it hedonistic high-seeking, maybe even "true abuse" in all meanings of word, and in that reference frame acceptable risk. Benzos probably would help somewhat but I would not trust them too much myself.

 

[Skorpio]

I recall that sodium channel activity is not great for heart over time, but I am not sure if I've got it right. Point was that pregabalin does not have that kind of serious feature, but there is much going on with that one also, like how it can have paradoxically pro-glutamate effect, so it could still pose some kind of risk in complex combinations of drugs that is not really ever been studied.

I would do that kind of combo myself, but it does not mean it is great for you, obviously I'd call it hedonistic high-seeking, maybe even "true abuse" in all meanings of word, and in that reference frame acceptable risk. Benzos probably would help somewhat but I would not trust them too much myself.

Pretty on point.

The sodium channel coke blocks causes the heart to spread its beats farther apart. This combined with the speeding up of the heart via norepinephrine release from coke (and ketamine) are the main risks. Benzos should mediate the norepinephrine release (or do little depending on how dependent you are).

Pregabalin doesn’t really block calcium channels, as much as it interferes with them getting inserted on the membrane in the cell. It differs from classic voltage gated calcium channel blockers as it hits a pretty diverse range of channels (all with an alpha2delta subunit composition). This decreases the cellular activity, but because these are so widely expressed in the brain you suppress some inhibitory circuits as well as excitatory circuits, leading to the mixed effect of gabapentinoids when compared with more traditional sedatives.

It certainly is a bunch of drugs, which does increase the chance of weird and unexpected stuff happening, but there is nothing that jumps out to me and seems like it’s straight up going to be a deadly combo (like say amyl nitrates and viagra).

 

[ativ;anhero]

Pretty on point.

The sodium channel coke blocks causes the heart to spread its beats farther apart. This combined with the speeding up of the heart via norepinephrine release from coke (and ketamine) are the main risks. Benzos should mediate the norepinephrine release (or do little depending on how dependent you are).

Pregabalin doesn’t really block calcium channels, as much as it interferes with them getting inserted on the membrane in the cell. It differs from classic voltage gated calcium channel blockers as it hits a pretty diverse range of channels (all with an alpha2delta subunit composition). This decreases the cellular activity, but because these are so widely expressed in the brain you suppress some inhibitory circuits as well as excitatory circuits, leading to the mixed effect of gabapentinoids when compared with more traditional sedatives.

It certainly is a bunch of drugs, which does increase the chance of weird and unexpected stuff happening, but there is nothing that jumps out to me and seems like it’s straight up going to be a deadly combo (like say amyl nitrates and viagra).

Thank you so much what if alcohol is also added

 

[Pissed_and_messed]

Cocaethylene is formed and that's bad news. And there are quite many sedatives there then. Even if I do those kind of messy combos sometimes I consider it a) too confusing b) fucking irresponsible and dangerous irregular habit I am trying to quit. Imagine coke wears off suddenly and you are complete mess, if you are tolerant to benzos it is not probably enough for complete respiratory depression, but it surely is risk factor and not recommended.

So glad I have managed to decrease alcohol intake so much, it kinda ruins other sedatives also in a way and can't use it correct way most of the time.

 

[ativ;anhero]

Cocaethylene is formed and that's bad news. And there are quite many sedatives there then. Even if I do those kind of messy combos sometimes I consider it a) too confusing b) fucking irresponsible and dangerous irregular habit I am trying to quit. Imagine coke wears off suddenly and you are complete mess, if you are tolerant to benzos it is not probably enough for complete respiratory depression, but it surely is risk factor and not recommended.

So glad I have managed to decrease alcohol intake so much, it kinda ruins other sedatives also in a way and can't use it correct way most of the time.

I only have like 1 or 2 strong beers

 

[Pissed_and_messed]

well yeah, if you ain't POURING it, but SIPPING, it should not be chaotic or expose you to respiratory depression.

 

[Skorpio]

It will be messier, and probably a bit harder on you.

Risk is a spectrum, and a lot of it comes down to the doses of drugs you do each time. The easier you take it in general the safer it will be. In general. That combo should generally be immediately safe for an average healthy person if kept in reasonable doses.

When doing drug combos I think keeping your doses lower than if you were doing a single drug is the safest as the pharmacology gets complex quick and it’s really hard to know definitively all of the things happening in the body.

 

[Littana]

yea thats a pretty taxing combo, flush te bash and enjoy the others in moderation id say and do if i were u , also keep the K a special treat as its really nasty when it starts fucking up ur bladder/stomach/ etc

 

[Halif2]

yea thats a pretty taxing combo, flush te bash and enjoy the others in moderation id say and do if i were u , also keep the K a special treat as its really nasty when it starts fucking up ur bladder/stomach/ etc

I agree with what you've written but I can't figure out what "te bash" is!