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COCAETHYLENE question

S

skybarstacey

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I understand that combining alcohol and cocaine creates a chemical metabolite in the body called cocaethylene....this in turn makes the coke high last longer.

My question is, in order to get the best/longest high from this, is it best to consume alcohol first and THEN blow a few lines? OR does it make more sense to do a few lines and then have a few drinks? OR does it not matter?

In the past I've snorted like 3 lines and then gone out with friends and had a wonderful time drinking, sometimes doing small lines at the bar simultaneously. This was enjoyable.

Any ideas from you guys?
 
cocaethylene...

is simple ester interchange, a methyl ester for an ethyl ester. Cocaine has two ester moieties (peices), they are "reversed esters" depends how you look at it. It would be best to have a high blood level of alcohol before doing the coke as ester interchange is an in-vivo (in the body) reaction that is catalysed by the same enzymes that decompose the methyl ester (it's just reverse biokinetics). in this case it is just that it is energetically easy for the methyl group that is cleaved to be re-esterified by ethanol in the bloodstream.
 
be aware that cocaethylene is believed to be much more cardiotoxic than plain cocaine, I suppose because it is a better channel blocker??
 
I seem to remember examples where the methyl ester was replaced with an isopropyl ester. Supposed to be more potent & longer lasting...
 
Cocaethylene is more cardiotoxic than cocaine and occurs due to the action of the enzyme that normally breaks cocaine down; in the presence of alcohol, pseudoesterase causes the biosynth of said drug from ethanol & cocaine metabolite benzoylecognine.

Wonder if the same thing happens with methylphenidate metabolite in the presence of blood alcohol?
 
Yes, in fact, methylphenidate does form ethylphenidate in vivo in the presence of EtOH. There is not too much research out there, put I recall seeing a poster at last year's neuroscience conference on this topic. The researchers demonstrated that, in humans, (l)-ethylphenidate is the only significant species generated after consumption of (dl)-methylphenidate and EtOH. Since both (l)-methylphenidate and (l)-ethylphenidate are pretty much inactive at the DAT, they concluded that EtOH doesn't significantly alter the methylphenidate experience.

Humans given enantiopure (d)-methylphenidate and EtOH did not seem to produce substantive levels of (d)-ethylphenidate or metabolites. Must have something to do with the stereospecificity of the esterase enzyme: (-)-cocaine is levorotary (overall) and (d)-methylphenidate is obviously dextro.
 
hmmm..im not sure i knew what i was getting into when i entered this advanced drug forum.

maybe i sound stupid, but did i actually get an answer? :S I just wanted to know if i should drink or rail a few lines first....?
 
^^I'm anxious to here an informative answer also.....
I'm going to try this soon and I was planning on taking 3 shots of whiskey, then railing a half gram of coke, (I dont have a coke tolernace).
I'm trying to find out if thats enough coke and alcohol to produce cocoaethylene.
 
I don't think it takes a whole lot of alcohol, but I'm not certain. I do know that you need to ingest the alcohol first, at least a half hour prior.
 
I wonder...

if you took coke with alcohol orally, that maybe passage through the gut (acid catalysed transesterification) and first pass metabolism through the liver might give more cocaethylene, first in the gut, and then coke to benzoylecognine in the liver, so that by the time it hits the bloodstream where the benzoyleconine could get re-esterified, your overall "yield" of cocaethylene would be greater than intranasal coke with a high blood alcohol content?
The trouble is, that you have a hard time synthesizing pure cocaethylene because the cocaine molecule has two ester groups. You would have to selectively remove the methyl ester with out cleaving the benzoyl ester to produce pure benzoylecognine, which then has to be re-esterified with ethanol, without scrambling of the benzoyl ester to any great degree. This is a problem to do by using chemical reagebts, but is relatively easier by selective methyl esterase enzymes in the bloodstream. The reason you form any cocaethylene at all is because when coke is cleaved to benzoylecognine, there is such a greater ethanol to methanol ratio in the bloodstream that the "energetically favorable backwards reaction of the catalytic enzyme to re-esterify with ethanol" can happen a lot easier. All in all, coke is easily and quickly metabolised and excreted by the body.
 
skybarstacey said:
hmmm..im not sure i knew what i was getting into when i entered this advanced drug forum.

maybe i sound stupid, but did i actually get an answer? :S I just wanted to know if i should drink or rail a few lines first....?
Click to expand...

Neither - if you have to use a stimulant, go with methylphenidate, amphetamine... in fact anything other than cocaine (or related local anaesthetics) as in the long run you'll do yourself (mostly your cardiovascular system) much less damage. If you must use coke, I'd suggest using a short acting benzo rather than alcohol to counteract any cocaine induced anxiety
 
does anyone know how dangerous this combination is? how many drinks mixed with how much coke is enough for a possible overdose?
 
Neither - if you have to use a stimulant, go with methylphenidate, amphetamine... in fact anything other than cocaine
Click to expand...

I couldn't agree more. Due to the Na+ channel blocking propensity of cocaine, it is far more cardiotoxic than any of the synthetic stimulants. There are so many better CNS stimulants that are less addictive, longer lasting and far less likely to cause arrhythmia, stroke and other deadly cardiac effects.
 
I been wasted drunk and then did a line of coke and it was VERY INTENSE. Cocathylene also increases the euphoria and it lasts a lot longer.
 
^ And is more cardiotoxic. One important thing (for me at least) is not to take something a lot more toxic just because it's 'a better hit'. There are certain things I avoid because of their toxicity and along with acute neurotoxicity, cardiotoxicity is up there at the top of my list
 
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