https://www.ncbi.nlm.nih.gov/pubmed/1723798
https://www.ncbi.nlm.nih.gov/pubmed/8570030
https://www.sciencedirect.com/science/article/pii/009130579190145R
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1479-8301.2006.00157.x
https://www.researchgate.net/public...f_rats_subchronically_treated_with_clonazepam
http://www.dr-bob.org/babble/20060417/msgs/635570.html
I find this of particular interest since clonazolam produces a much mor prominent effect concerning depression. Anyone who knows that feeling as unipolar depression sets down on you may have noted that clonazepam helps a little. If one sits down and takes clonazolam, that increase in serotonin is VERY pronounced. Anyone who has taken a modest dose of p-TAP or p-Me aminorex or 4,p-dimethylaminorex alone will know exactly what I mean. Increasing serotonin alone is quite subtle. You do feel happier, more contented but more importantly, it does lift that depression. You feel chilled out. Sadly, none of those compounds is safe and they produce their own toxic profile and they display tachyphylaxis. They work for a day or two but soon you are back where you started if not worse.
Now clonazolam IS better but it has it's own set of negative effects mediated by it's α1 affinity. I'm sure we have read the stories from the most mild-mannered members of REM to the most reactionary racists who until recently blighted our screens. What is needed is a nitrobenzodiazepine that doesn't have affinity for the α1 subunit (and ideally not the α5 subunit either). Well a couple of such agents are currently undergoing tests in animal models. They are α2/α3 selective (like pyrazolam) so they don't have much abuse potential (lets be honest, you need about 10 pyrazolam to get any kind of buzz and I haven't seen many cases of people becoming dependent because let's fact it, they aren't much fun). Well, I was visiting The Netherlands and suddenly I was hit by a REALLY bad downer out of nowhere. I mean, I've been looking forward to the visit, we had friends staying looking after the cats, I hadn't seen them in ages - all great stuff.
But after the first night I was feeling just AWEFUL. The tricyclics I am given do help but only in a suicide-prevention manner. I still hate every moment. Well, an old friend arrived who knows me better than I know myself. She was STRAIGHT on the case. 1 hour before a mean she gave me 5mg of her own custom benzo. This has a (S) 3-methyl moiety and a couple of other bits to make it REALLY selective. I sat down and took 2 x 2mg caps. After about 1 hour I could feel it..... all of that badness was slipping away. It was a gos-sent. Now I don't know the exact structure and she's developing it as a medical product but all I can say is that it WORKED.
The dose was limited to 4mg 1 hour before bed-time. I slept and didn't have awful dreams. I could think of others. I bought her flowers, I bought the family we were staying with flowers, I bought my wife flowers.... I bought her sisters flowers. It WORKED. Now I'm just 1 person and this was just 1 occasion but anyone who knows that specific serotonin 'happy place' will know just what I mean. After 10 days I stopped fearing the worst..... and it didn't happen!.
So this is statistically of no value but I'm interested to know if others have benefitted from clonazepam, clonazolam or similar. Was it just a placebo? I didn't dare take a DRI because I associate those serotonin tingles with the before part of me taking a couple of dexis but i didn't WANT stimulating..... all very odd but if the a2 & a3 don't form dependence (and open question) then we MAY have a new fast-acting antidepressant in the works and I for one am excited by this. I've lost too many people and so has she so she was my little sister that night; she loves me and she looked after me.
I am an out and proud philogynist. I don't dislike men but I tend to expect the best of ladies and the worst of men. Every bad thing that someone has done to me has been another man. Every good thing that someone has done for me has been a lady. Maybe I am biased but on reflection, I have NO male friends. I mean, I have about 6 REALLY close friends. My wife is first (obviously) but the other 5 are like the sisters I don't have. I have been VERY lucky.... and I love them all.
https://www.ncbi.nlm.nih.gov/pubmed/8570030
https://www.sciencedirect.com/science/article/pii/009130579190145R
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1479-8301.2006.00157.x
https://www.researchgate.net/public...f_rats_subchronically_treated_with_clonazepam
http://www.dr-bob.org/babble/20060417/msgs/635570.html
I find this of particular interest since clonazolam produces a much mor prominent effect concerning depression. Anyone who knows that feeling as unipolar depression sets down on you may have noted that clonazepam helps a little. If one sits down and takes clonazolam, that increase in serotonin is VERY pronounced. Anyone who has taken a modest dose of p-TAP or p-Me aminorex or 4,p-dimethylaminorex alone will know exactly what I mean. Increasing serotonin alone is quite subtle. You do feel happier, more contented but more importantly, it does lift that depression. You feel chilled out. Sadly, none of those compounds is safe and they produce their own toxic profile and they display tachyphylaxis. They work for a day or two but soon you are back where you started if not worse.
Now clonazolam IS better but it has it's own set of negative effects mediated by it's α1 affinity. I'm sure we have read the stories from the most mild-mannered members of REM to the most reactionary racists who until recently blighted our screens. What is needed is a nitrobenzodiazepine that doesn't have affinity for the α1 subunit (and ideally not the α5 subunit either). Well a couple of such agents are currently undergoing tests in animal models. They are α2/α3 selective (like pyrazolam) so they don't have much abuse potential (lets be honest, you need about 10 pyrazolam to get any kind of buzz and I haven't seen many cases of people becoming dependent because let's fact it, they aren't much fun). Well, I was visiting The Netherlands and suddenly I was hit by a REALLY bad downer out of nowhere. I mean, I've been looking forward to the visit, we had friends staying looking after the cats, I hadn't seen them in ages - all great stuff.
But after the first night I was feeling just AWEFUL. The tricyclics I am given do help but only in a suicide-prevention manner. I still hate every moment. Well, an old friend arrived who knows me better than I know myself. She was STRAIGHT on the case. 1 hour before a mean she gave me 5mg of her own custom benzo. This has a (S) 3-methyl moiety and a couple of other bits to make it REALLY selective. I sat down and took 2 x 2mg caps. After about 1 hour I could feel it..... all of that badness was slipping away. It was a gos-sent. Now I don't know the exact structure and she's developing it as a medical product but all I can say is that it WORKED.
The dose was limited to 4mg 1 hour before bed-time. I slept and didn't have awful dreams. I could think of others. I bought her flowers, I bought the family we were staying with flowers, I bought my wife flowers.... I bought her sisters flowers. It WORKED. Now I'm just 1 person and this was just 1 occasion but anyone who knows that specific serotonin 'happy place' will know just what I mean. After 10 days I stopped fearing the worst..... and it didn't happen!.
So this is statistically of no value but I'm interested to know if others have benefitted from clonazepam, clonazolam or similar. Was it just a placebo? I didn't dare take a DRI because I associate those serotonin tingles with the before part of me taking a couple of dexis but i didn't WANT stimulating..... all very odd but if the a2 & a3 don't form dependence (and open question) then we MAY have a new fast-acting antidepressant in the works and I for one am excited by this. I've lost too many people and so has she so she was my little sister that night; she loves me and she looked after me.
I am an out and proud philogynist. I don't dislike men but I tend to expect the best of ladies and the worst of men. Every bad thing that someone has done to me has been another man. Every good thing that someone has done for me has been a lady. Maybe I am biased but on reflection, I have NO male friends. I mean, I have about 6 REALLY close friends. My wife is first (obviously) but the other 5 are like the sisters I don't have. I have been VERY lucky.... and I love them all.
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