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Clinical Studies

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smooch0

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Joined
Aug 11, 2011
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Has any one done these 'clinical studies' of new medications ect.. any weird things happen to them? thinking about doing one but its a first in human study for this drug "called ALD403 intended for treatment of Migraine. ALD403 blocks the calcitonin Gene-related Peptide, or CGRP" lol have no idea what the last sentence means.
Usally sell my blood to them when they need some (if any1 interested i can pm there email n shiz)

Any way it says talk to people around you before going into the study lol, You can get a bit of money if you don't mind jabs all day lol
 
Most are very safe, I know many people who have done clinical studies. They tend to pay very well.

Can you provide a link to the specific one you're looking at?
 
^ Maybe not this one.

First human studies on any drug are always Phase I clinical trials testing for toxicity. You will be given the drug in either a single ascending dose study (SAD) or multiple ascending dose study (MAD). These studies are designed so that participants (you) experience toxic effects of the drug in order to establish the maximum tolerated dose (MTD) before moving to Phase II trials for efficacy.

These trials stop as soon as you experience toxic effects, meaning no real harm to participants. But be aware that the idea of this is that you DO experience toxic effects. Keep that in mind when signing up, and that's coming from a scientist potentially conducting trials of this nature. Although you will be doing the science community a favour and there's no way for us to get drugs to market (you know, to help people and shit) without participants such as yourself donating their health and time to these studies.
 
^ True to some extent. There is almost always a predetermined dose limit based on animal studies beyond which they will not advance, even if there are no toxic effects below this level. This level would typically be lower than the equivalent dose which caused toxicity in animals. Whilst you're right that phase I trials are generally riskier, they are still mostly very safe.
 
Oh yeah. They are by and large very safe, but as with everything there are exceptions. I wont go quoting any spectacular ones as that wont help studies searching for participants.

But your incorrect with the predetermined dose limit. Admittedly ranges for toxicity are mapped out in animals and human doses start at a fraction of the drugs LD50 (if theres even such a figure) but when looking for the Maximum tolerated dose before knowing what range your efficacy lies in - well you've got to give toxic doses. No way round it.
First human study, this is definitely the type of trial being conducted. Best of luck! To be honest I probably make it out to be more doom and gloom than it is, if you get assigned to a SAD study that uses drug naive individuals than chances are you'll score a non-toxic dose. But literally drawing straws to see who gets the nasty one, and in the spirit of clinical trials this is all randomly assigned.
 
Wow dont think I'd want to do it but if it ended up helping cure or reduce the pain of migraines then that would be something to be proud of.

Could you make decent living doing these things?
 
I signed up at one of these places once, and was asked to be involved in the clinical trial of an alzheimer's medication. They were paying a few thousand dollars for about ten days inpatient. I didn't end up doing it because I couldn't get that time off work or uni, and I was a bit worried about taking a medication that was potentially affecting my brain.

I've also done a later stage clinical trial of modafinil for meth withdrawal, that involved far less money, I think only 50 bucks. I did that one hoping that modafinil would help me get off meth, but I think I got the placebo.
 
Mr Blonde said:

If you're interested in reading about a drug trial gone wrong, check out this. I remember when this was in the news years ago.
Click to expand...

Really helping source participants there haha. "Catastrophic systemic organ failure" Sounds like fun!

Typically the type of trial that smooch0 is looking at primarily are after young healthy males with little to no variables including smoking and medication.
If your a young healthy male then sure, there's money to be made at only a slight risk to your well being. (although knowing that toxic doses are given)

Trials testing for efficacy of drugs almost always require you to have a specific condition, and generally those see you being approached by your treating professional rather than publicly advertised as with Phase I toxicity trials seen here.
 
I did two of these when I lived in the UK 7 years ago.
One was for a memory drug for Alzheimers. Had to go into hospital twice overnight and do some memory tests. Got paid about $1500.

Second one was for blood sugar medication for Diabetes. Had to stay in hospital for 10 days and got paid $4500.
Both of these tests used drugs that had been tested on humans in low doses.

Almost got into one here for an Asthma study but my Asthma was playing up and I wasn't stable enough to be let in.

Would definatley do another one.
 
A girl at work did one where she had to eat heaps of chocolate for a week, and get a bunch of blood tests. That one sounded alright.

I don't like the idea of being experimented on...lots of blood tests :( can't imagine sitting around all day being dosed up on drugs to check toxicity. I'd be stressing out, especially after reading Mr Blondes link. Toxicity tests would only a small percentage of the clinical trials going on though right?
 
^ I imagine so. That particular one I linked to was not a 'toxicity test' though, it was a case of unknown human variables leading to problems when they started trials in people.

The trials are mostly very safe from what I understand, not many people get serious adverse effects. They usually give you enough information on what the trial they are recruiting for is, so you can do a bit of research first to see how you feel. I just tried to find an example of the type of email you receive, but it appears to have disappeared.
 
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