• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

Cleanest stims for chronic use?

Who said anything about lifelong amphetamine binges? Obviously, taking tweak-a-thon doses is unhealthy. Theraputic doses are a different matter, however. One must be careful to take a dose that does not affect their ability to get a reasonable night's sleep. For whatever reason (the mystery of ADD), amphetamine has never had an anorectic effect for me, so malnutrition has also never been an issue.
 
Last edited:
Ya if you take it as prescribed you'll be fine; if you have ADHD then tell a psychiatrist that you want to get titrated onto vyvanse, desoxyn, or focalin(these are all the good isomers)
I believe they can still prescribe you pemoline, but the risk of toxicity is up to you
 
Pemoline is completely off the market. Which is a shame--I never got a chance to try it, but supposedly it was one of the 'cleanest' feeling stimulants. However, considering the possibility of liver failure and serotonergic cardiotoxicity (known to happen with aminorex and 4-MAX), it doesn't seem suited for long-term use. As for Vyvanse, I don't think it really offers anything over and above Dexedrine. The N-link lysine residue makes it effectively Dexedrine XR, but since it is not available as a generic, that is one expensive lysine.
 
I never tried dexedrine spansules, but vyvanse works great; by this i mean I no longer have to worry about popping pills 3 times aday, so i feel a lil more productive on my uninterrupted day, ya know?

And vyvanse is rate limited by the enzyme, making it so u cant overdose, whereas with dexedrine xr u can (but i dont take anywhere near the rate limiting amount, i think its sum where around 200mg lisdexamfetamine dimesylate where the mysterious hydrolytic enzyme becomes saturated)
 
I think I would have to take 140mg of the Vyvanse form of (d)-amphetamine to approach my daily dose of Dex XR. I guess if Dexedrine XR ever becomes impossible to get, I'll switch over. I've never gone above 100mg of (d)-amphetamine in a 24hr period (and those were some intense 'mission-critical' periods), so I don't think ODing is a real worry.
 
Last edited:
Oh don't get me wrong i dont think anone would take more than 100mg dexamph sulfate in a day; but what if a baby got a hold of the bottle of pills?
 
Can you maintain your sanity with chronic stim use? 3-4 months on Adderall, averaging 20-30mg/day...I'm starting to have doubts.
 
Its not chornic its intermittant by the way;
if you're going to have adderall at high levels in ur blood stream chronically then no u cant do it for 3-4 mo.
But if u take it as ur dr prescribed ull be fucking fine forever
 
20mg/day for 3 months? Yeah, without a problem. It might be more difficult if you're using the XR, but I never had any problems. I usually took 10mg/day, but I took 20mgs/day for quite a while, as well.
 
The interesting thing about amphetamine is that intermittent use (especially at high doses) may actually sensitize individuals to the side effects of the drug. Whereas chronic low-dose amphetamine seems to attenuate the side effects but (at least for me) preserves the therapeutic effect. Of course, what everyone has said about chronic binge doses of stimulants is right (as seen in meth or crack addicts, for example): eventually you get manic enough to go bat-shit crazy, especially with lasting sleep-deprivation.
 
e1evene1even said:
While maybe not strong enough for everybody, I think neurotransmitter precursors like DLPA and tyrosine are probably the best bet long term, and things like ginseng and kola nut. Betel nut is the fifth most widely used 'drug' on the planet (afiak) yet most people have never heard of it. Its got its share of problems and is not totally benign, but can be a fairly effective stimulant, maybe something to look into. I think going the pharm route will eventually fuck most people, its just a matter of when in my opinion.
Click to expand...

Betel nut chewing can give you mouth cancer. That option is out. As for Kola nut, it's just caffeine! Caffeine is caffeine is caffeine, no matter what the "it's natural, so it's better" folks claim.
 
beside the mouth cancer i do not think even pure arecoline whic is the main active is a desirable long term stim or acute for that matter

there are better
 
dexedrine spansules are OK for me, but honestly after being on amphetamines since around 7th grade, im finding the lifestyle is never easy.

im totally dependent, i still can get totally high, and it much love and hate.

in terms of legitimate usage , Vyvance might be the safest/ while still being moderatly strong, its basically dexedrine, but with a protein-bound molecule.

Sleep is the most important thing. and I only use around 3 days a week now. about 60-100mg a day. (and I chew up my dexedrine beads, to bypass the XR)
 
LuxEtVeritas said:
is the lysine conjugated AMPH not under US scheduling as being made specifically to not be abusable

i assume so
Click to expand...


No, it's still scheduled, C2 even. I'm sure Vyanase's manufacturer wasn't exactly thrilled about that.
 
The Monkey Mantra said:
Betel nut chewing can give you mouth cancer. That option is out. As for Kola nut, it's just caffeine! Caffeine is caffeine is caffeine, no matter what the "it's natural, so it's better" folks claim.
Click to expand...

Caffeine is caffeine I agree, but the claim that kola nut is "just caffeine" is incorrect. Kola nut contains numerous psychoactive alkaloids (theobromine being one example) and together they have a synergistic effect in my experience.

As for Betal nut, I agree that the risk of mouth cancer may make it less desirable, but the vast history of use by hundreds of millions of people worldwide makes me think its relatively benign and the risks fairly low. Modern pharmaceutical stimulants in comparison have a very short history of human use, and the full risks of chronic long term use may not surface for some time.

I think for chronic use it might be best to alternate among the stimulants believed to be relatively safe at this time. Take one for a few months and switch etc.
 
ziddy said:
Can you maintain your sanity with chronic stim use? 3-4 months on Adderall, averaging 20-30mg/day...I'm starting to have doubts.
Click to expand...


Compared with the way bipolar depression (specifically the hypomanic phase and the subsequent actue depressive phase) can fuck with your head, stimulants for the most part haven't given me many problems as they are beginners compared with the shite manic depression can put you through (have had periods of up to a year of continuous chronic use of amphetamine etc in the past without any 'invasion of the shadow people' or similar ;) )

That said, I did go a bit fruit loop from methamphetamine use, but that's the king hell, alpha male of central stimulants =D
 
Modafinil, GABA, glutamate

Jamshyd said:
As for modafinil, everything I have read yet about its method of action (GABA antagonism, Glutamate agonism) spells out excitotoxicity and probably long-term emotional disasters.
Click to expand...

I don't really know what I'm talking about here, so take this with a grain of salt... But I think if modafinil was a non-specific GABA antagonist or glutamate agonist, you'd be dead at a dose slightly higher than the one required to get an effect. This contradicts modafinils relative safety.

So if it is acting on these transmitters, it's only affecting them in a very specific way, so I think it's not as simple as GABA antagonism in some special neurons = anxiety or other emotional problems.

Do you have other evidence to think that modafinil will result in emotional problems or was it only the above? (This may sound a little blunt but I don't mean it that way :))
 
I'm looking for a thread strictly on pramiracetam, and see you guys talking about d-amp. Thought I'd chime in a quick bit and say I find 2-FMA superior to d-amp in every single way.

The bruxism is also more or less non-existent.

Too bad it's so new though, as not much obviously be known about it's long term use. I already stack with racetams daily, and since doing so, my 2-FMA intake has gone down from orally dosing 80-85mg twice a day, to vaporizing ~20mg a 2-3 times a week total.
 
DexterMeth said:
I'm looking for a thread strictly on pramiracetam, and see you guys talking about d-amp. Thought I'd chime in a quick bit and say I find 2-FMA superior to d-amp in every single way.

The bruxism is also more or less non-existent.

Too bad it's so new though, as not much obviously be known about it's long term use. I already stack with racetams daily, and since doing so, my 2-FMA intake has gone down from orally dosing 80-85mg twice a day, to vaporizing ~20mg a 2-3 times a week total.
Click to expand...

Thought I'd mention I only need 20mg 2-fma for all day stimulation, 30mg gives euphoria for the first half and rest if I smoke weed(this is with somehwat of a tolerance, but maybe I'm sensitive to it). Also I've tried pramiracetam, it is good for clear headed emotionless focus and studying without distractions, but can be depressing and give brain fog(also it doesn't really give you energy, you'd either need to be in a great mood/etc or have some caffiene/amp/whatever with it). If you have other questions on it I can probably give you some ideas.
 
You must log in or register to reply here.
Top