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Stimulants Clarification on lisdexamphetamine (Vyvanse)

TheRoach16

Greenlighter
Joined
Oct 17, 2012
Messages
2
So as I understand it, Vyvanse is appealing to doctors because of lower abuse potential. However, it is metabolized to standard amphetamine in the BLOOD, not the digestive tract. So, is the drug really anything but a delayed release pure d-amphetamine?

For example, Ive heard from many people that you cannot effectively snort Vyvanse. However, if the metabolism to amphetamine occurs in the blood, then why would it matter how it enters the bloodstream?

Just been curious.
 
Vyvanse contains dextroamphetamine that is coupled with an amino acid (L-lysine). Lisdexamfetamine has to be ingested in order for the intestinal tract to convert it into active dextroamphetamine. This conversion can not take place without the aid of digestive enzymes and therefore won't work well if snorted.
 
Ya, but studies show that hydrolysis occurs in the blood. Not the intestinal tract.

"The intact prodrug, LDX, was readily absorbed from the GI tract after oral administration,"

"LDX was metabolized to d-amphetamine by human RBCs but not by other blood fractions, such as white blood cells or platelets. "

Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898170/
 
It's a prodrug for dextroamphetamine. Meant to be consumed orally.

Strange because most people consume amphetamines orally anyways. But w/e. I guess it has a lower abuse potential.
 
I find it more euphoric than adderall, so to answer your question it is mainly because it can't be snorted, iv'd, or smoked that doctors consider it to have low-abuse potential....

Also, it is released very slowly into the bloodstream over the course of about 12 hours....so there isn't really a big RUSH at any time.

That being said, yes, to me it feels just like extended-release dexedrine.
 
It's a prodrug for dextroamphetamine. Meant to be consumed orally.

Strange because most people consume amphetamines orally anyways. But w/e. I guess it has a lower abuse potential.

also strange that most tweakers i know use vyvanse more than any other pharm. amp, and by tweakers i mean crystal meth enthusiasts. i found it to be too subtle for any use other than a light, longlasting stimulant. I would see it as a better feeling alternative to coffee that is less dirty and requires less redosing. I would take vyvanse if I didnt sleep well the previous night, or if i was hungover. maybe for ADD but IME it doesnt help very much. others seem to think that it is good for everything, not me.

@OP, if you have low stimulant tolerance, you may get a very nice high from vyvanse, but if you have a tolerance, then you will most likely find it uninteresting, there are very fewside effects and virtually 0 comedown effects. if its the only stimulant you've tried, you should keep your tolerance low, so that when you want to use a stimulant, vyvanse works for you. other stimulants will be much less pleasant from the side effects and comedown, so if you can use vyvanse as your main amphetamine, you will save yourself a lot of discomfort, paranoia, muscle pains, hallucinations, cravings, and most of all - money. if you have already developed a tolerance, however, it goes without saying that it is a very weak high in comparison to other stimulants, and not worth the money. There is a way to turn the lisdexamfetamine into normal dextroamphetamine, using some sort of stomach enzyme (typically trypisin) and can be taken orally, and if you want to try this, im sure the search engine has your answers. Remember to keep your amphetamine use as infrequent as possible, because they are more addictive IME than most other drugs. Even adderall was powerful enough to have me in a 3 year habit, and that's nothing compared to most speed habits, they can get heavy. vyvanse could lose its magic, and then you do your cycle through progressiively stronger amphetamines until you have to smoke or IV a ton of meth to get that same original stateof absolute godlike stimulation, and even then its still nothing like the first time, and never will be as good as it used to be, only giving you the side effects and just enough "euphoria" for you to feel normal. Idk, all I'm saying is be careful with amphetamines, man, they can be used as tools or taken as poison, it's up to you which one it's gonna be.

Stay safe!
 
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Yeah it has to be taken orally and digested in order for it to enter the blood stream. The studies on the duration of Vyvanse say it last 12-14hrs but that is just bullshit. All they are going by is the presence of d-amp in the blood, not if it is controlling ADD. Its never lasted more than 3 hrs for me and a bunch of others I've read about. Plus the comedown is pretty harsh for d-amp, pretty close to the crash of 30mg-45mg adderall ir ime

I personally prefer adderall bc it is more effective at helping me "get in the zone" when I need to study for a test or write a paper. I usually take it twice a week only when I have to. I think the l-amp causes a rougher comedown but also helps with the focus. Just my experience
 
I got some for the first time a couple nights ago. Emptied capsules, crushed the contents are finely as I could which resulted in a powder, took 80mg of it and caught a nice buzz. Slept 14 hours later, felt like shit the next day, as I always do with amphetamines.
 
I got some for the first time a couple nights ago. Emptied capsules, crushed the contents are finely as I could which resulted in a powder, took 80mg of it and caught a nice buzz. Slept 14 hours later, felt like shit the next day, as I always do with amphetamines.

if you try to catch a buzz of ir by dosing high and focussing on your high, than you will be dissapointed with vyvanse, as its rec value is much more subtle than traditional amphetamines, and is actually less stimulating then it is calming and almost sedating. also, if you plan on using vyvanse for actual therapeutic purposes, then dont ever use it recreationally, because after doing that, its hard to use it to focus. dexedrine is a better ADD med IMO, but vyvanse's lack of side effects makes it a a worthy alternative to dexedrine for those who are very sensitive its side effects. the ideal choice ADD med would be desoxyn, because its basically like dexedrine with less side effects, incredibly longer duration, more euphoria, and no comedown to speak of. however, your doc will most likely refuse to prescribe it, because it is dextromethamphetamine (crystal meth essentially), therefore is considered to be highly abusable, although they are less abusable IME than adderall (when i say less abusable, i mean that they are less likely to be used in an irresponsible manner, such as redosing, bingeing, and becoming addicted) and seems to illicit responsible, safe, and healthy use of the chemical. however, dexedrine is just one step behind desoxyn, so i would be perfectly fine with a dexedrine script as they serve the same function, but unfortunately, society has so much stigma to meth that asking for a safe, medically appropriate prescription for methamphetamine is like a bomb threat or something, like i have had doctors ask me to leave their office and not come back after asking for a desoxyn prescription.

as for the l-amp, some people think that it helps to focus by giving you a kick in the ass which causes you to work rapidly, however, that actually makes your rapidly flowing thoughts more dissorganized, whereas on d-amps, they flow calmy, quickly and efficiently, but you dont really notice it because the lack of a strong physical component to the effects make you think thst youre not feeling as much effects as you would normally be feeling while focusing on adderall. the d-amps are the ones you want, and giving it a few weeks to try, youll get what im talking about, and youll notice that you have been way more since taking the meds, but you havent been experiencing the same problems that you would get from adderall. if you still prefer adderall, then thats just your opinion, although i cant imagine why someone would prefer adderall to dexedrine, the levo amp just makes you physically uncomfortable and also makes your face look very sullen and unhealthy. dexedrine is more appropriate as a medication, whereas adderall feels like a street drug, with cut and everything.
 
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