Claim that special fermentation of ergot can produce LSD

[red22]

Interest in this claim.

 

[sekio]

I don't think anyone has genetically engineered yeast or bacteria to make LSD; you'd need them to make diethylamine. And besides Claviceps spp. mostly makes all the ergopeptides, not plain lysergic acid (amide).

Maybe they have. I would imagine the reference is pretty well hidden for obvious reasons.

 

[Abject]

I would imagine the reference is pretty well hidden for obvious reasons.

indeed

 

[endotropic]

Have you seen this thread, Mr. Red?

http://www.bluelight.org/vb/threads/296027-Pharming-Drugs

f&b claims "duck_racer" and "MGS" have access to this article, although I'm pretty sure those three are all long gone now. Maybe someone around here has a way to contact f&b otherwise?

 

[sekio]

morninggloryseed occasionally posts here. Maybe they'll read this.

 

[red22]

Great find, endotropic.

 

[Zeds(NCO2CH2CH3)2]

Aries save us all here is to furthermore chaos unto the well kept 1969 royal society of chemistry paper. Note it is not an easy how to and the amount of expertise needed in column chromatography is no lie.

Biosynthesis of ergot alkaloids. Lysergylalanine as precursor of amide-type alkaloids
G. Basmadjian, H. G. Floss, D. Gröger and D. Erge
J. Chem. Soc. D, 1969, 418-419
DOI: 10.1039/C29690000418, Paper

The intermediate is believed to be a thioester which is substituted with d alanine then which is oxidative cleaved to yield the isopropionaldehyde amide that cyclisizes to form ergometrine. My advice is use N-ethyl glycine maybe. Or diethyl amide in a basic buffer.

Zedsdead