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  • BDD Moderators: Keif’ Richards

Citalopram, Agomelatine and hypersalivation

FionaFayruz

Greenlighter
Joined
Mar 28, 2013
Messages
9
Location
South Africa
Hi everyone

I am hoping someone has experienced the same problem I'm currently experiencing and can advise me.
About eight months ago, I started hypersalivating and experiencing tingling all over my body as well as some inability to get to words. Needless to say, I had every test in the book and my physician suggested it could be my Citalopram (25mg a day). I also take 25mg of Clobazam every day (good ol' benzos!). My diagnosis, 20 years ago, was depression, social phobia, vomiting phobia and general anxiety.

My physician put me on Thaden for a week and it didn't help, plus she didn't renew my prescription when I was about to run out, so the experiment failed and I had to take the Citalopram again. Fast-forward a couple of months and my brand-new psychiatrist agreed with the diagnosis *I* came up with after doing a lot of research - serotonin syndrome. I have been on Citalopram for about 20 years and never had the problem before, which is odd ... but anyway, it seemed the only solution left!

My psychiatrist took me off Citalopram and put me on Agomelatine, saying the latter shouldn't affect those receptors that work on the salivary glands. Wrong! I was *still* hypersalivating. Worse, the Agomelatine made me feel like hell after two weeks - shaky, nauseous, anxious, in fact badly suicidal, wanting to hit things, shouting at people, etc. I decided to off it on my own and haven't actually felt depressed at all (four days later). I just feel tired and a little miserable that although the salivation issue has improved somewhat it's still there.

What I did notice was that my saliva ceased to be thick, sticky and constant, and is now inconstant, thin, foamy and not as copious (ugh). So I am *assuming* that my physiology is just not able to tolerate any kind of antidepressant any more. Full stop.

My questions - yes, there are a couple - are: How long before the antidepressants will leave my system and I will cease to salivate like this? Will it in fact stop, or do you think there's been some damage to my neural pathways (unlikely, but who knows, right?)? Finally, if I can't tolerate antidepressants, what could I take instead? And do you think my benzo is also contributing to the hypersalivation? I have xerostomia at the same time, weirdly enough. Dry mouth and drooling simultaneously - great, right? :?

Any advice will be great!
 
I am not entirely convinced of serotonin syndrome; SSRI drugs work in a way that in not completely understood, and it could have been because of some unknown property of citalopram itself. Either way, the half life of the agomelatine is less than two hours, which is quite short. There are chances it may already have, but I would need to know your dosage per day to estimate when you can expect the agomelatine to have left your system.

Also, though we may be able to give you our ideas as to what the cause of your salivation issue is, most of us are not doctors. You should try and get it checked out by a professional, but in the mean time there are products sold in pharmacies to relieve dry mouth. Perhaps speak with the pharmacist to get the best kind.
 
Thanks, guys.

I have had every single test in the book to determine the cause, ruling out everything from HIV and cancer to MS and salivary gland cysts in the process. I am basically healthy. I am using Biotene products for my dry mouth, but they are not helping. I am desperate as two doctors, one physician, a psychiatrist, a dentist and a periodontist have now seen me but given me no *definitive* diagnosis. I have now come off *all* my medication, including Urbanol, to see if that will help. I'm essentially unmedicated for the first time in 20 years! I have no idea where to turn next but the problem seems to be persisting. Anyway, thanks for trying ... I appreciate it. The Agomelatine - I was taking just one of those little pills from the pack - not sure what the dosage is.
If it *is* the citalopram, could it really take over a month to work out of my system??
 
Oh, you're having issues with dry mouth...Xerostomia would be the term you would be looking for (or hypOsalivation).
 
Nope ... I have both. Both xerostomia/dry mouth/hyposalivation, and drooling/hypersalivation. I am drooling copiously but my periodontist says I also have xerostomia. Go figure!
 
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