Opioids cimetidine and grapefruit juice timing for oxy and hydro?

[oddliger]

I'm going to take 10mg oxy and 17.5 mg hydro and I have both cimetidine and white grapefruit juice. I wasn't just wondering the time I should take this and how much? Will it be a huge potentiator? Or just a tad bit? Thank you so much! (my normal dose is about 30mg hydro)

 

[ErgicMergic]

30 minutes before dosing your opiates orally should be fine, just be very careful with your dose if you're opiate naive because, yes, it WILL be a big potentiation effect. The opioids will kick in slower but last much longer, as the inhibition of CYP2D6 liver enzymes by cimetidine prevents elimination from blood by the 2D6 alleles.

Also, be careful with mixing cimetidine with benzos, as inhibition of CYP3A4 potentiates most benzos in the same manner, and don't take both White GFJuice and cimetidine at the same time, imo.