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N&PD Moderators: Skorpio
Cholinergics + Sigma 1 receptor
- Thread starter Mask0ff
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Correct, cognition and neurogenesis.i have reviewed thousands of meds and never found cholinergic drugs besides donepezil that also potently agonise the sigma 1 receptor
but in other type of meds there is Opipramol (selective) and Fluvoxamine
Opipramol - Wikipedia
en.wikipedia.org
Fluvoxamine - Wikipedia
Oof, a TCA. Fluvoxamine i'm also looking at but would be combining an SSRI with ache inhibitor, want a second option on ACHE inhibitor. Any idea on if you can combine 2 sigma-1 agonists?
I have biases against ache inhibitors after reading too many toxicology papers on low level organophosphate exposure in agricultural workers and the increase in neurodegeneration. This may very well not carry over to non-covalent inhibitors, but the fear has been planted in me.
Make sense, every exogenous ligand has it's side effects just about. Could you provide a link? It can't be all that bad.
Just found this: https://pubmed.ncbi.nlm.nih.gov/32798937/Here's one: https://www.sciencedirect.com/science/article/pii/S0160412017305822#bb0110
I like this more than pure epidemiological stuff because they not only tie risk to organophosphate exposure, but they look into paroxonase1 (PON1) functional polymorphisms. PON1 breaks down organophosphates, so the finding that the slow metabolism phenotypes increase Parkinson's risk when around organophosphates strengthens the argument that they are causitive.
I've only found one single study on this:
Protection by sigma-1 receptor agonists is synergic with donepezil, but not with memantine, in a mouse model of amyloid-induced memory impairments
izo
Bluelighter
opipramol seems to be the widest sold antidepressant in germany. i found it to be ok. you have to take many times the dosage that it recommended. i took it rectally once and it produced a certain taste in the mouth, something that seems to be the case with sigma ligands.
izo
Bluelighter
in higher doses it calms you down, thats all i remember.
plumbus-nine
Bluelighter
For me opipramol did nothing, literally nothing and I ended up taking whole blisters in search for just something. Might have been just me tho.
But there's certainly something about sigma, just look @ DXM or ibogaine, for example.
