Study CBT (Cannabitriol) is an Anti-Estrogen compound

[Snafu in the Void]

Cannabitriol - Wikipedia

en.wikipedia.org

Cannabinoid as Potential Aromatase Inhibitor Through Molecular Modeling and Screening for Anti-Cancer Activity | Dhaka University Journal of Pharmaceutical Sciences

Induced Fit Docking and Automated QSAR Studies Reveal the ER-α Inhibitory Activity of Cannabis sativa in Breast Cancer

Background: Breast Cancer (BC), a common fatal disease and the deadliest cancer next to lung cancer, is characterized by an abnormal growth of cells in the tissues of the breast. BC chemotherapy is marked by targeting the activities of some receptors such as Estrogen Receptor alpha (ER-α). At...

www.eurekaselect.com

reposting from reddit, thought some of you might find this valuable, haven't looked through it myself yet

 

[Darksidesam]

So in theory, this could be useful to men who are working out / bodybuilding?

 

[Snafu in the Void]

So in theory, this could be useful to men who are working out / bodybuilding?

I presumed as much

maybe this belongs more in OD

 

[cdin]

or to women with breast cancer

 

[G_Chem]

I’m gonna be getting this soon as possible. Anti-estrogen sounds lovely considering cannabis as a whole has testosterone lowering properties.

-GC

 

[gibberish-noise]

nice, which sort of product might have this present in desirable quantities? haven't read through enough literature on the topic to speculate as to whether d8 d9 d10 etc would contain the most, or if it would be somehow possible to extract it yourself - imagine any product isolate would be prohibitively expensive, perhaps just cynicism but not unduly warranted

 

[Snafu in the Void]

or to women with breast cancer

that's just where the science is at, from what I've read it's a bad idea for women to use this in general probably... unless being treated for cancer

 

[cdin]

that's just where the science is at, from what I've read it's a bad idea for women to use this in general probably... unless being treated for cancer

yeah, i only know about it because my partner is dealing w breast cancer atm and about to be put on tamoxifen for this very reason. And it's side effects are TErrIble. a cannabinoid option to reduce estrogen with few side-effects could be really amazing.

 

[Phobos]

yeah, i only know about it because my partner is dealing w breast cancer atm and about to be put on tamoxifen for this very reason. And it's side effects are TErrIble. a cannabinoid option to reduce estrogen with few side-effects could be really amazing.

Sadly, most of Tamoxifen's side effects come directly from it's intended method of action, blocking Estradiol from interacting with the Estrogen Receptors.
This makes Tamoxifen a drug of the SERM class, while CBT is an AI, meaning it prevents Estradiol from being produced.
I don't know how effective CBT is, but strong AIs are even worse than SERMs in regards to side effects.

 

[Serotonin101]

Sadly, most of Tamoxifen's side effects come directly from it's intended method of action, blocking Estradiol from interacting with the Estrogen Receptors.
This makes Tamoxifen a drug of the SERM class, while CBT is an AI, meaning it prevents Estradiol from being produced.
I don't know how effective CBT is, but strong AIs are even worse than SERMs in regards to side effects.

I'd say most AIs aside from maybe exemestane I'd rank worse on the body than serms for the lost part especially in terms of their effects on lipids.

 

[red22]

I thought this was referring to this: https://science.bio/product/cbt-isoex-oil-500mg/

Cannabicitran: A new naturally occurring tetracyclic diether from lebanese Cannabis sativa

GVB Biopharma Begins Research on CBT (Cannabicitran), Unexplored Cannabinoid

God, you hear about a new cannabinoid every day...

 

[Serotonin101]

I thought this was referring to this: https://science.bio/product/cbt-isoex-oil-500mg/

Cannabicitran: A new naturally occurring tetracyclic diether from lebanese Cannabis sativa

GVB Biopharma Begins Research on CBT (Cannabicitran), Unexplored Cannabinoid

God, you hear about a neww cannabinoid every day...

Well that made me sad seeing science dot bio is closing

 

[arrall]

Well that made me sad seeing science dot bio is closing

I had no idea... Guess I'll be pulling the trigger on a few compounds that I've been holding off on.
EDIT: Fuck, they sold out of all the good stuff. Phenylpiracetam, Bromantane, Phenibut, GABA powder, etc.

 

[red22]

In that case, here's a coupon:

SHOP2022

35% OFF on all orders

40% OFF on $250 and up

45% OFF on $500 and up

 

[red22]

God, you hear about a new cannabinoid every day...

The alternative cannabanoid market is growing, as many companies will synthetisize cannabanoids the are found in trace quantities during analysis that are done on new strains that keep getting made. Cannabiquinone is a newer cannabanoid that is being made.

 

[negrogesic]

I had no idea... Guess I'll be pulling the trigger on a few compounds that I've been holding off on.
EDIT: Fuck, they sold out of all the good stuff. Phenylpiracetam, Bromantane, Phenibut, GABA powder, etc.

That isn't the good stuff last i looked. I'd go for more interesting stuff, weird curiosities that would just add to my collection and i might take once or twice, like oxytocin or THC-O

 

[arrall]

That isn't the good stuff last i looked. I'd go for more interesting stuff, weird curiosities that would just add to my collection and i might take once or twice, like oxytocin or THC-O

Oxytocin acetate has little to no activity when ingested, and the cannabinoids are USA-only.

 

[red22]

EDIT: Fuck, they sold out of all the good stuff. Phenylpiracetam, Bromantane, Phenibut, GABA powder, etc.

...I thought GABA didn't cross the BBB...

 

[Serotonin101]

...I thought GABA didn't cross the BBB...

It doesn't. Still sold because people buy it. Same with carnitine supplements that basically don't do shit unless you mega dose it or get the injectable equine/Grey market versions and combine with insulin. And B-alanine is basically useless as well because it needs to hit saturation dose. Demand is there, so they keep supplying it

 

[osft]

It doesn't. Still sold because people buy it. Same with carnitine supplements that basically don't do shit unless you mega dose it or get the injectable equine/Grey market versions and combine with insulin. And B-alanine is basically useless as well because it needs to hit saturation dose. Demand is there, so they keep supplying it

Interesting. So the times I used extended release B/a and got major pins and needles/itch in my limbs (I was looking for speed on 25min mountainbike runs and similar duration stair climbing) was I experiencing placebo effect to see it help? Because it did *seem* to. Serious question. Not being combative, just realized on proof read I'd better say that.

CBD-
- oils have done absolutely nothing for me. Zero. tried a few.
- some capsules taken before bed seem to really help with anxiety. The ones where they look like weed put in a grinder then in a capsule, and I burp up m/j scent seem to work. Unfortunately I bought some that don't have scent or effect.
- the time they really seemed to help was in a ptsd (& meth use recovery) phase where an well meaning Ex GF talked with me a couple hours and set me up with somewhere to buy them. I could believe a bit that that was placebo effect.