Catuabine Extract (35%) - Inexperienced - Not bad!

[Ham-milton]

I decided to start a thread here on the subject because I was so impressed with my first time.

I took roughly 250-300mg sublingually w/ a nice whiskey to aid absorption. I held it for 5-10 minutes (I Know, I know, I should have done a better job).

T+6 (post spit): I'm beginning to feel something coming up in my chest, a tightening or something. I'm not sure what it is to be honest.

T+13: I'm definitely feeling it, but it's not what I expected, or even close. It feels more like I'd expect from oral methylphenidate (minus the overpowering urge to chat, but the euphoria just isn't there at this dose.

T+25: What the hell? I thought I peaked at t+13, but obviously not. My head feels faster, and my chest feels the same, but it's not any worse. There's a bit of dizzyness, but again, unlike anything else I've ever used.

I can definitely tell that it's a DARI, but it doesn't feel like others I've had.

I'm not sure I'd call it a stimulant, because it doesn't have that clenchy feeling- but then again, I'm at such a low dose here.

Next time I'm gonna try twice as much and maybe a little more alcohol to aid absorption.

For now I'll say it's worth using, but I'm worried about the chest thing a little. Double might be too much, maybe I'll try a little lower.

I'll keep you all posted.

I just wanted to include a little bit about what it is. Anyway, this plant contains tropane alkaloids similar to cocaine (they'd definitely be considered analogues). A study has shown that it's a potent DARI and DA releaser, and also a SE releaser and reuptake inhibitor. If it didn't inhibit the reuptake, perhaps it'd have an MDMA sparkle. Hard to say, we don't have a pure SE releaser.

 

[Swerlz]

Do you know which Catuabine you've done? A, B, C, or D?

 

[Ham-milton]

it was a full spectrum extract, but 35% catuabine alkaloids.

 

[Beenhead]

Im goin to leave this open to see where it goes because this is such an obscure compound, but we like much more detail in the reports please add some more detail!!

 

[Swerlz]

What inspired you to pursue this chem??

Wiki says its not known to have any physiological effects

 

[Ham-milton]

Don't trust wikipedia. I have a paper that shows that it's a fairly potent DA releaser and reuptake inhibitor, but also an SE releaser and Reuptake inhibitor. Quite like cocaine, I might add. I can AIM-it to you, if aol-im

T+0:00
snort ~200mg of the extract.
yikes, this shit stings badly. Average coke will be 30-40% cocaine, but that's baking soda and laxative added. This is plant material. Burns like hell. It's quite obvious that this stuff lacks any of the aneasthetic activity of cocaine. That's a major plus- that's what makes IV cocaine so cardiotoxic.

t+0:05
starting to feel the effects, it's light right now, but definitely growing.

t+0:10
I think this will probably be the peak, it's come on quite strong now. I feel all chatty, but not as euphoric as I would have expected from a similar snorted dose of methylphenidate (or 200mg of a 35% methylphenidate powder). I wonder if that's from the SRI effects?

t+0:20
It's still going, it's not changing a whole lot at this point. I'm sitting on the computer trying to work on a song, but it's going poorly. Music is not enhanced at all. Maybe I'll try writing.

I pick up a poem I've been working on for a week or so now. The words seem to come easier, but they want to come too fast. That's not good for poetry- where word selection is everything.

It's too easy to slip into a sort of sing-songy rhythm in this poem, which really doesn't reflect natural speech patterns. No annoying tendency to rhyme though!

t:0:35
effects are starting to diminish. I sort of feel like doing another line, but remembering how back it hurt makes it easy to resist it.

t+0:45
effects are totally gone.

No real crash, not surprising from one line. I feel a little tired in the head, and still craving slightly, but it's really easy to resist. I think if I had pure powder, it'd be easy to blow through it in a night.

 

[Ham-milton]

Neurochemical evidence for antidepressant effects of T. catigua extract

The antidepressant-like activity of T. catigua extract was further confirmed by monoamine uptake and release experiments. A one-way ANOVA analysis showed that T. catigua extract (10–300 μg/ml) reduced, in a significant manner, the synaptosomal uptake of [3H]dopamine [F(5,12)=85.1, P<0.01] or [3H]serotonin [F(5,12)=27.2, P<0.01] in membrane preparations from rats. The extract of T. catigua significantly reduced the uptake of [3H]dopamine when assessed in the concentrations of 10, 30, 100 and 300 μg/ml (Fig. 4), whereas it significantly affected the uptake of [3H]serotonin only at the concentrations of 100 and 300 μg/ml (Fig. 4). The calculated mean IC50 values accompanied by the 95% confidence limits were (in μg/ml) 35 (17–73) and 68 (35–130), for dopamine and serotonin uptake, respectively. On the basis of IC50 values, the T. catigua extract was about two times more potent in inhibiting dopamine than serotonin uptake. Otherwise, T. catigua extract (10–300 μg/ml) was not able to significantly affect the synaptosomal uptake of [3H]noradrenaline [F(5,12)=10.29, P<0.05] (Fig. 5). The positive control drugs cocaine (3.4 μg/ml), fluoxetine (35 μg/ml) and desipramine (30 μg/ml) produced a marked inhibition of [3H]dopamine (Fig. 4), [3H]serotonin (Fig. 4) and [3H]noradrenaline uptake, respectively. In vitro effects of T. catigua extract on dopamine uptake were confirmed by experiments indicating that the longterm treatment of rats with T. catigua (200 mg/kg, p.o.), once a day for up to 42 days, caused a significant inhibition of [3H]dopamine uptake [one-way ANOVA: F(2,10)=9.6, P<0.01] in synaptosomal preparations (Fig. 5). On the other hand, [3H]serotonin uptake was not significantly affected by chronic treatment with T. catigua extract (Fig. 5). The results also demonstrate that chronic treatment with fluoxetine caused a significant reduction of both serotonin (Fig. 5) and dopamine (Fig. 5) uptake.
Monoamine release experiments indicated that in vitro incubation with T. catigua extract (10 to 300 μg/ml) significantly
increased the release of [3H]dopamine [one-way ANOVA: F(5,12)=285.2, P<0.01] and [3H]serotonin [oneway ANOVA: F(4,10)=19.5, P<0.01] in synaptosomal fractions obtained from rats. The extract of T. catigua increased the release of [3H]dopamine in a significant way when assessed in the concentrations of 10, 20, 40, 80, 100 and 200 μg/ml (Fig. 6), whilst it significantly enhanced the release of [3H]serotonin only at the concentrations of 100 and 300 μg/ml (Fig. 6). the calculated mean EC50 values (accompanied by the 95% confidence limits, μg/ml) were 23 (22–24) and 111 (40–309), for dopamine and serotonin release, respectively. When the EC50 values were analyzed, T. catigua extract was about fivefold more potent in inducing dopamine than serotonin release.

 

[grue]

The few successful reports I've read for tea had the effects tailing off at 6-8 hours.

I still honestly think there is something very interesting with this plant, but I've tried and tried with it ...

 

[Ham-milton]

it definitely is. I only know of one person who offers the catuabine extract, and I've just been getting free samples to test and report back on it. This thread has become my public reporting back.

I'm not getting paid in any way, so I'm definitely not exagerating the effects. I'm just really impressed with this stuff (I've had a lot of other stuff, but some of it wasn't things that really need new reports; I tested a 20mg/ml salvinorin A tincture (dried and smoked on foil) yesterday- a crazy potent extract that requires a syringe to even consider properly measuring.